CDKN1A cyclin dependent kinase inhibitor 1A [Gallus gallus (chicken)] - Gene

Summary

Symbol: CDKN1Aprovided by CGNC
Full Name: cyclin dependent kinase inhibitor 1Aprovided by CGNC
Primary source: CGNC:49142
See related: Ensembl:ENSGALG00010025613
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CIP1
Orthologs: all
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Genomic context

Location:: chromosome: 26

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	26	NC_052557.1 (1629435..1638659)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	26	NC_052598.1 (1600100..1609343)

Chromosome 26 - NC_052557.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Uhrf1 and Uhrf2 induced cell senescence, by arresting skeletal progenitors at the S phase and upregulating the expression of p21.
Title: UHRF genes regulate programmed interdigital tissue regression and chondrogenesis in the embryonic limb.
The cell cycle-related gene CIP1 showed higher expression in the cultured chicken embryonic fibroblast cells than that of cultured chicken primordial germ cells.
Title: Gene pathways and cell cycle-related genes in cultured avian primordial germ cells.
EZH2-mediated repression of p21(WAF1/CIP1) contributes to disruption of the neuroepithelium (NE) structure, correlating with alteration of the Rho pathway, and reduces neural progenitor proliferation.
Title: EZH2 regulates neuroepithelium structure and neuroblast proliferation by repressing p21.
Consistent with the central role of p21 on cell senescence, the transcriptional effects induced by overexpression of Btg2 are attenuated by silencing p21.
Title: Apoptosis during embryonic tissue remodeling is accompanied by cell senescence.
The cell cycle inhibitor p21 was significantly increased, whereas cyclin D1, a cell cycle promoter, decreased in sustained hyperglycemia compared with controls
Title: Hyperglycemia slows embryonic growth and suppresses cell cycle via cyclin D1 and p21.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cyclin-dependent kinase inhibitor 1

Names: cdk inhibitor CIP1 (p21); cyclin-dependent kinase inhibitor 1A (p21, Cip1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396336.1 → NP_001383265.1 cyclin-dependent kinase inhibitor 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAENSK010000356

UniProtKB/TrEMBL

A0A8V1A3Q7, A0A8V1A8M0

Related

ENSGALP00010038657.1, ENSGALT00010062513.1
NM_204396.2 → NP_989727.2 cyclin-dependent kinase inhibitor 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000356

UniProtKB/TrEMBL

A0A8V1A8M0, M9TKU1

Conserved Domains (1) summary

pfam02234
Location:21 → 66

CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052557.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

1629435..1638659

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046904082.1 → XP_046760038.1 cyclin-dependent kinase inhibitor 1 isoform X1

UniProtKB/TrEMBL

A0A8V1A8M0, M9TKU1
XM_046904083.1 → XP_046760039.1 cyclin-dependent kinase inhibitor 1 isoform X1

UniProtKB/TrEMBL

A0A8V1A8M0, M9TKU1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052598.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

1600100..1609343

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046932837.1 → XP_046788793.1 cyclin-dependent kinase inhibitor 1 isoform X1

UniProtKB/TrEMBL

Q8AYE7
XM_046932838.1 → XP_046788794.1 cyclin-dependent kinase inhibitor 1 isoform X1

UniProtKB/TrEMBL

Q8AYE7