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CREM cAMP responsive element modulator [ Gallus gallus (chicken) ]

Gene ID: 378903, updated on 3-Apr-2024

Summary

Symbol
CREMprovided by CGNC
Full Name
cAMP responsive element modulatorprovided by CGNC
Primary source
CGNC:49136
See related
Ensembl:ENSGALG00010004425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ICER
Orthologs
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Genomic context

Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (12931761..12963477, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (12959698..12991338, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene gap junction protein delta 4 Neighboring gene cyclin Y Neighboring gene uncharacterized LOC107052602 Neighboring gene translation initiation factor IF-2-like Neighboring gene cullin 2 Neighboring gene par-3 family cell polarity regulator

Genomic regions, transcripts, and products

General protein information

Preferred Names
cAMP-responsive element modulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278132.1NP_001265061.1  cAMP-responsive element modulator isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BU485989, BX931695, BX934897, CN234043, CN235463
    Conserved Domains (2) summary
    cd14690
    Location:238292
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:65102
    pKID; pKID domain
  2. NM_001278133.2NP_001265062.1  cAMP-responsive element modulator isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the UTRs and coding region, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    JAENSK010000036
    UniProtKB/TrEMBL
    F1N847
    Conserved Domains (2) summary
    cd14690
    Location:223277
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:5087
    pKID; pKID domain
  3. NM_001278134.1NP_001265063.1  cAMP-responsive element modulator isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the UTRs and coding region, compared to variant 1, including the lack of multiple 3' coding exons. It initiates translation at a downstream in-frame start codon. The encoded isoform (3) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BX930447, CN232429
    Conserved Domains (1) summary
    pfam02173
    Location:5087
    pKID; pKID domain
  4. NM_001278135.2NP_001265064.1  cAMP-responsive element modulator isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks multiple 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    JAENSK010000036
    Conserved Domains (1) summary
    cd14690
    Location:69123
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
  5. NM_204387.3NP_989718.2  cAMP-responsive element modulator isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the UTRs and coding region, compared to variant 1, including the lack of multiple 5' coding exons. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (4) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    JAENSK010000036
    UniProtKB/TrEMBL
    Q7T3L4, R4GII4
    Conserved Domains (1) summary
    cd14690
    Location:69123
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    12931761..12963477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917410.1XP_046773366.1  cAMP-responsive element modulator isoform X4

  2. XM_015281264.4XP_015136750.1  cAMP-responsive element modulator isoform X3

    UniProtKB/TrEMBL
    F1N847
    Conserved Domains (2) summary
    cd14690
    Location:223277
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:5087
    pKID; pKID domain
  3. XM_015281263.4XP_015136749.1  cAMP-responsive element modulator isoform X2

    Conserved Domains (2) summary
    cd14690
    Location:238292
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:65102
    pKID; pKID domain
  4. XM_015281262.4XP_015136748.1  cAMP-responsive element modulator isoform X1

    UniProtKB/TrEMBL
    A0A1D5PT13
    Related
    ENSGALP00010006044.1, ENSGALT00010010339.1
    Conserved Domains (2) summary
    cd14690
    Location:238292
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:65102
    pKID; pKID domain
  5. XM_046917407.1XP_046773363.1  cAMP-responsive element modulator isoform X1

    UniProtKB/TrEMBL
    A0A1D5PT13
  6. XM_046917416.1XP_046773372.1  cAMP-responsive element modulator isoform X5

  7. XM_046917423.1XP_046773379.1  cAMP-responsive element modulator isoform X6

  8. XM_025147004.3XP_025002772.1  cAMP-responsive element modulator isoform X6

    UniProtKB/TrEMBL
    Q7T3L4, R4GII4
    Conserved Domains (1) summary
    cd14690
    Location:3993
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12959698..12991338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910220.1XP_046766176.1  cAMP-responsive element modulator isoform X4

  2. XM_046910219.1XP_046766175.1  cAMP-responsive element modulator isoform X3

  3. XM_046910217.1XP_046766173.1  cAMP-responsive element modulator isoform X2

  4. XM_046910216.1XP_046766172.1  cAMP-responsive element modulator isoform X1

    UniProtKB/TrEMBL
    A0A1D5PT13
  5. XM_046910218.1XP_046766174.1  cAMP-responsive element modulator isoform X1

    UniProtKB/TrEMBL
    A0A1D5PT13
  6. XM_046910221.1XP_046766177.1  cAMP-responsive element modulator isoform X5

  7. XM_046910223.1XP_046766179.1  cAMP-responsive element modulator isoform X6

  8. XM_046910222.1XP_046766178.1  cAMP-responsive element modulator isoform X6