U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hspa5 heat shock protein 5 [ Danio rerio (zebrafish) ]

Gene ID: 378848, updated on 9-Sep-2025
Official Symbol
hspa5provided by ZNC
Official Full Name
heat shock protein 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-031001-11
See related
Ensembl:ENSDARG00000103846 AllianceGenome:ZFIN:ZDB-GENE-031001-11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb865; fb60h09; fi36d04; zgc:55994; zgc:77606; wu:fb60h09; wu:fi36d04
Summary
Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Acts upstream of or within response to hypoxia and response to yeast. Located in extracellular region. Is expressed in several structures, including central nervous system; digestive system; immature eye; prechordal plate; and sensory system. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See hspa5 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 5 NC_133180.1 (2000271..2008182)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 5 NC_007116.7 (2713778..2721686, complement)

Chromosome 5 - NC_133180.1Genomic Context describing neighboring genes Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene si:ch73-55i23.1 Neighboring gene leucine zipper, putative tumor suppressor family member 3a Neighboring gene FAST kinase domains 5 Neighboring gene RAB35, member RAS oncogene family a Neighboring gene guanine nucleotide binding protein (G protein), gamma 10

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators. Kaokhum N, et al. Mol Cell Proteomics, 2022 Dec. PMID 36182100, Free PMC Article
  2. A transgenic zebrafish model for monitoring xbp1 splicing and endoplasmic reticulum stress in vivo. Li J, et al. Mech Dev, 2015 Aug. PMID 25892297
  3. CRISPR/Cas9-Mediated Constitutive Loss of VCP (Valosin-Containing Protein) Impairs Proteostasis and Leads to Defective Striated Muscle Structure and Function In Vivo. Voisard P, et al. Int J Mol Sci, 2022 Jun 16. PMID 35743185, Free PMC Article
  4. Comparative effects of nodularin and microcystin-LR in zebrafish: 1. Uptake by organic anion transporting polypeptide Oatp1d1 (Slco1d1). Faltermann S, et al. Aquat Toxicol, 2016 Feb. PMID 26769064
  5. Identification of HSPA8 as an interacting partner of MAB21L2 and an important factor in eye development. Seese SE, et al. Dev Dyn, 2023 Apr. PMID 36576422, Free PMC Article

See all (175) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.
    Title: Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
part_of endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
endoplasmic reticulum chaperone BiP
Names
bip
glucose-regulated protein, 78kDa
heat shock 70kDa protein 5 (glucose-regulated protein)
NP_998223.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213058.1 → NP_998223.1  endoplasmic reticulum chaperone BiP precursor

    See identical proteins and their annotated locations for NP_998223.1

    Status: PROVISIONAL

    Source sequence(s)
    BC052971
    UniProtKB/TrEMBL
    Q7SZD3
    Related
    ENSDARP00000131952.1, ENSDART00000169404.3
    Conserved Domains (3) summary
    cd10241
    Location:26 → 401
    HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
    PTZ00009
    Location:29 → 641
    PTZ00009; heat shock 70 kDa protein; Provisional
    cl21456
    Location:583 → 640
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133180.1 Reference GRCz12tu Primary Assembly

    Range
    2000271..2008182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous