U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KCNS2 potassium voltage-gated channel modifier subfamily S member 2 [ Homo sapiens (human) ]

Gene ID: 3788, updated on 18-Sep-2024

Summary

Official Symbol
KCNS2provided by HGNC
Official Full Name
potassium voltage-gated channel modifier subfamily S member 2provided by HGNC
Primary source
HGNC:HGNC:6301
See related
Ensembl:ENSG00000156486 MIM:602906; AllianceGenome:HGNC:6301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KV9.2
Summary
Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of delayed rectifier potassium channel activity. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 4.8), urinary bladder (RPKM 1.1) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KCNS2 in Genome Data Viewer
Location:
8q22.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (98426958..98432853)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (99552416..99558311)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (99439186..99445081)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 3 Neighboring gene WASH complex subunit 3 pseudogene Neighboring gene VISTA enhancer hs908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:99434278-99434886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19397 Neighboring gene microRNA 9903 Neighboring gene RNA, U6 small nuclear 748, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:99601941-99603140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27679 Neighboring gene ATP5PF pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily S member 2
Names
delayed-rectifier K(+) channel alpha subunit 2
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
voltage-gated potassium channel subunit Kv9.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020697.4NP_065748.1  potassium voltage-gated channel subfamily S member 2

    See identical proteins and their annotated locations for NP_065748.1

    Status: VALIDATED

    Source sequence(s)
    AB032970, AP003355, BC034778, BI819243
    Consensus CDS
    CCDS6279.1
    UniProtKB/Swiss-Prot
    A8KAN1, Q9ULS6
    Related
    ENSP00000287042.4, ENST00000287042.5
    Conserved Domains (2) summary
    pfam00520
    Location:186421
    Ion_trans; Ion transport protein
    pfam02214
    Location:19118
    BTB_2; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    98426958..98432853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    99552416..99558311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)