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KCNS2 potassium voltage-gated channel modifier subfamily S member 2 [ Homo sapiens (human) ]

Gene ID: 3788, updated on 28-Oct-2019

Summary

Official Symbol
KCNS2provided by HGNC
Official Full Name
potassium voltage-gated channel modifier subfamily S member 2provided by HGNC
Primary source
HGNC:HGNC:6301
See related
Ensembl:ENSG00000156486 MIM:602906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KV9.2
Expression
Biased expression in brain (RPKM 4.8), urinary bladder (RPKM 1.1) and 8 other tissues See more
Orthologs

Genomic context

See KCNS2 in Genome Data Viewer
Location:
8q22.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (98426958..98432853)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (99439250..99443025)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 3 pseudogene Neighboring gene VISTA enhancer hs908 Neighboring gene RNA, U6 small nuclear 748, pseudogene Neighboring gene serine/threonine kinase 3 Neighboring gene ATP synthase-coupling factor 6, mitochondrial-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Voltage gated Potassium channels, organism-specific biosystem (from REACTOME)
    Voltage gated Potassium channels, organism-specific biosystemVoltage-gated K+ channels (Kv) determine the excitability of heart, brain and skeletal muscle cells. Kv form octameric channel with alpha subunits that forms the pore of the channel and associated be...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily S member 2
Names
delayed-rectifier K(+) channel alpha subunit 2
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
voltage-gated potassium channel subunit Kv9.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020697.4NP_065748.1  potassium voltage-gated channel subfamily S member 2

    See identical proteins and their annotated locations for NP_065748.1

    Status: VALIDATED

    Source sequence(s)
    AB032970, AP003355, BC034778, BI819243
    Consensus CDS
    CCDS6279.1
    UniProtKB/Swiss-Prot
    Q9ULS6
    Related
    ENSP00000287042.4, ENST00000287042.5
    Conserved Domains (2) summary
    pfam00520
    Location:186421
    Ion_trans; Ion transport protein
    pfam02214
    Location:19118
    BTB_2; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    98426958..98432853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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