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RTN4 reticulon 4 [ Gallus gallus (chicken) ]

Gene ID: 378790, updated on 5-Sep-2025
Official Symbol
RTN4provided by CGNC
Official Full Name
reticulon 4provided by CGNC
Primary source
CGNC:6163
See related
Ensembl:ENSGALG00010016706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
NOGO
Orthologs
human mouse all
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See RTN4 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (2691979..2739734)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (2624632..2663029)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417848 Neighboring gene uncharacterized LOC107052842 Neighboring gene EMAP like 6 Neighboring gene uncharacterized LOC100858220 Neighboring gene spectrin beta, non-erythrocytic 1 Neighboring gene uncharacterized LOC107052843

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. NOGO-A induction and localization during chick brain development indicate a role disparate from neurite outgrowth inhibition. Caltharp SA, et al. BMC Dev Biol, 2007 Apr 14. PMID 17433109, Free PMC Article
  2. Developing microsatellite markers from cDNA: a tool for adding expressed sequence tags to the genetic linkage map of the chicken. Ruyter-Spira CP, et al. Anim Genet, 1998 Apr. PMID 9699267
  3. Development and mapping of polymorphic microsatellite markers derived from a chicken brain cDNA library. Ruyter-Spira CP, et al. Anim Genet, 1996 Aug. PMID 8856919
  4. A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1. Huebner EA, et al. J Biol Chem, 2011 May 20. PMID 21454605, Free PMC Article
  5. Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system. Petrinovic MM, et al. Development, 2010 Aug 1. PMID 20573699

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1.
    Title: A multi-domain fragment of Nogo-A protein is a potent inhibitor of cortical axon regeneration via Nogo receptor 1.
  2. Nogo-A is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching
    Title: Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system.
  3. Nogo-A plays a functional role in the determination of neural identity and/or differentiation and also appears to play a later role in the networking of large projection neurons during neurite formation and synaptogenesis.
    Title: NOGO-A induction and localization during chick brain development indicate a role disparate from neurite outgrowth inhibition.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endoplasmic reticulum tubular network formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
reticulon-4
Names
neurite outgrowth inhibitor
NP_001335216.2

Length

  • 1159

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277087.4 → NP_001264016.1  reticulon-4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2, also known as NOGO-C) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    JAENSK010000060
    UniProtKB/TrEMBL
    Q7T224
    Conserved Domains (1) summary
    pfam02453
    Location:12 → 176
    Reticulon; Reticulon

  2. NM_001348287.3 → NP_001335216.2  reticulon-4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1, also known as NOGO-A1).
    Source sequence(s)
    JAENSK010000060
    UniProtKB/TrEMBL
    A0A8V0YQV4, A0A8V0Z4A4
    Related
    ENSGALP00010023388.1, ENSGALT00010040330.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    2691979..2739734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025148489.3 → XP_025004257.2  reticulon-4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YQV4

  2. XM_025148490.3 → XP_025004258.2  reticulon-4 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YQV4

  3. XM_025148491.3 → XP_025004259.1  reticulon-4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z489, Q4FZ82
    Related
    ENSGALP00010023378.1, ENSGALT00010040317.1
    Conserved Domains (1) summary
    pfam02453
    Location:170 → 334
    Reticulon

  4. XM_025148492.3 → XP_025004260.1  reticulon-4 isoform X6

    UniProtKB/TrEMBL
    A0A8V0YXM4, Q4FZ83
    Related
    ENSGALP00010023381.1, ENSGALT00010040320.1
    Conserved Domains (1) summary
    pfam02453
    Location:151 → 315
    Reticulon

  5. XM_015283344.4 → XP_015138830.1  reticulon-4 isoform X5

    UniProtKB/TrEMBL
    Q4FZ82
    Related
    ENSGALP00010023396.1, ENSGALT00010040342.1
    Conserved Domains (1) summary
    pfam02453
    Location:158 → 322
    Reticulon; Reticulon

  6. XM_015283345.4 → XP_015138831.1  reticulon-4 isoform X7

    UniProtKB/TrEMBL
    Q4FZ83
    Related
    ENSGALP00010023401.1, ENSGALT00010040348.1
    Conserved Domains (1) summary
    pfam02453
    Location:139 → 303
    Reticulon; Reticulon

  7. XM_046938398.1 → XP_046794354.1  reticulon-4 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YQT3
    Related
    ENSGALP00010023374.1, ENSGALT00010040311.1

  8. XM_046938399.1 → XP_046794355.1  reticulon-4 isoform X9

    UniProtKB/TrEMBL
    Q7T224

  9. XM_015283346.4 → XP_015138832.1  reticulon-4 isoform X8

    UniProtKB/TrEMBL
    Q7T224
    Conserved Domains (1) summary
    pfam02453
    Location:6 → 170
    Reticulon; Reticulon

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2624632..2663029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_204366.2: Suppressed sequence

    Description
    NM_204366.2: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: RTN4 (GeneID:57142).
Nucleotide Protein Strain
Heading Accession and Version

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