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nodal3.1.L nodal homolog 3, gene 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 378537, updated on 11-Apr-2024

Summary

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Official Symbol
nodal3.1.L
Official Full Name
nodal homolog 3, gene 1 L homeolog
Primary source
Xenbase:XB-GENE-5964411
See related
EnsemblRapid:ENSXLAG00005005234
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
nr3; Xnr3; Xnr-3; nr3-A; nodal3; nodal3-A; nodal3.1
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Genomic context

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Location:
chromosome: 3L
Exon count:
3
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (141478446..141480825)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (125319528..125321977)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016716603.1 (283..698)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A2 L homeolog Neighboring gene transforming, acidic coiled-coil containing protein 1 L homeolog Neighboring gene nodal homolog 3-A-like Neighboring gene nodal homolog 3, gene 2 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xnr3 affects brain patterning via cell migration in the neural-epidermal tissue boundary during early Xenopus embryogenesis. Morita M, et al. Int J Dev Biol, 2013. PMID 24307296
  2. A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor. Yokota C, et al. Development, 2003 May. PMID 12668633
  3. Primary structure requirements for Xenopus nodal-related 3 and a comparison with regions required by Xenopus nodal-related 2. Ezal CH, et al. J Biol Chem, 2000 May 12. PMID 10799488
  4. LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter. McKendry R, et al. Dev Biol, 1997 Dec 15. PMID 9441678
  5. Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3. Hansen CS, et al. Development, 1997 Jan. PMID 9053324

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The nodal3 genes of Xenopus laevis are present in gene clusters on chromosome XLA3L. This gene cluster has been completely lost from the syntenic S chromosome regions. Nodal3 genes in X. laevis and X. tropicalis were independently expanded and/or evolved in concert within each cluster by gene conversion.
    Title: Genome organization of the vg1 and nodal3 gene clusters in the allotetraploid frog Xenopus laevis.
  2. Xnr3 affects anterior ectoderm migration around the neural-epidermal boundary to induce a specific neural pattern abnormality.
    Title: Xnr3 affects brain patterning via cell migration in the neural-epidermal tissue boundary during early Xenopus embryogenesis.
  3. The pro-region of Nodal-related 3 is both necessary and sufficient for its BMP inhibition.
    Title: Two distinct domains in pro-region of Nodal-related 3 are essential for BMP inhibition.
  4. The mature region of Nodal-related 3 entirely differs from other Nodal-related proteins in its mechanism of action.
    Title: Monomeric mature protein of Nodal-related 3 activates Xbra expression.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within gastrulation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nodal homolog 3-A
Names
nodal related 3, TGF-beta related growth factor
nodal-related protein 3-A
xnr3-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085790.1 → NP_001079259.1  nodal homolog 3-A precursor

    See identical proteins and their annotated locations for NP_001079259.1

    Status: PROVISIONAL

    Source sequence(s)
    U25993
    UniProtKB/Swiss-Prot
    Q91609
    UniProtKB/TrEMBL
    A0A974DFN3, B7ZQ58
    Related
    ENSXLAP00005015426.1, ENSXLAT00005015712.1
    Conserved Domains (2) summary
    smart00204
    Location:299 → 397
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:53 → 139
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    141478446..141480825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91609.1 GenPept UniProtKB/Swiss-Prot:Q91609

Gene LinkOut

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Molecular Biology Databases
Research Materials