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gad1b glutamate decarboxylase 1b [ Danio rerio (zebrafish) ]

Gene ID: 378441, updated on 14-Jun-2025
Official Symbol
gad1bprovided by ZNC
Official Full Name
glutamate decarboxylase 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030909-3
See related
Ensembl:ENSDARG00000027419 AllianceGenome:ZFIN:ZDB-GENE-030909-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gad1; GAD67
Summary
Predicted to enable glutamate decarboxylase activity. Acts upstream of or within gamma-aminobutyric acid biosynthetic process. Predicted to be active in cytoplasm and presynaptic active zone. Is expressed in nervous system and neural tube. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; developmental and epileptic encephalopathy 89; drug psychosis; and heroin dependence. Orthologous to human GAD1 (glutamate decarboxylase 1). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
all
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See gad1b in Genome Data Viewer
Location:
chromosome: 6
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (4544205..4578574)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (3827750..3862113)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene Sp5 transcription factor b Neighboring gene glutamate-rich 2 Neighboring gene uncharacterized LOC141386164 Neighboring gene uncharacterized LOC141386163 Neighboring gene golgi reassembly stacking protein 2 Neighboring gene tousled-like kinase 1b Neighboring gene uncharacterized LOC141386160

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. On the objectivity, reliability, and validity of deep learning enabled bioimage analyses. Segebarth D, et al. Elife, 2020 Oct 19. PMID 33074102, Free PMC Article
  2. The expression of GAD67 isoforms in zebrafish retinal tissue changes over the light/dark cycle. Connaughton VP, et al. J Neurocytol, 2001 Apr. PMID 11875278
  3. The Serotonergic System Tracks the Outcomes of Actions to Mediate Short-Term Motor Learning. Kawashima T, et al. Cell, 2016 Nov 3. PMID 27881303
  4. Cre-Dependent Anterograde Transsynaptic Labeling and Functional Imaging in Zebrafish Using VSV With Reduced Cytotoxicity. Kler S, et al. Front Neuroanat, 2021. PMID 34720892, Free PMC Article
  5. Investigation of spinal cerebrospinal fluid-contacting neurons expressing PKD2L1: evidence for a conserved system from fish to primates. Djenoune L, et al. Front Neuroanat, 2014. PMID 24834029, Free PMC Article

See all (203) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. relative expression domains of the dlx and gad1 genes in the zebrafish telencephalon and diencephalon
    Title: The relationship between dlx and gad1 expression indicates highly conserved genetic pathways in the zebrafish forebrain.
  2. the distribution of GAD67-expressing cells highly resembles the distribution of gamma-aminobutyric acid (GABA)/GAD67-expressing cells found in the early zebrafish (teleost) forebrain, suggesting a prosomeric fate map of GABAergic cell populations
    Title: The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods.
  3. High levels of GAD67 mRNA were observed in the intermediate and ventral parts of the medial pallium
    Title: Molecular characterization and comparative localization of the mRNAs encoding two glutamic acid decarboxylases (GAD65 and GAD67) in the brain of the African lungfish, Protopterus annectens.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid biosynthetic process IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
glutamate decarboxylase 1b
Names
glutamate decarboxylase 1
NP_919400.1
XP_009300378.1
XP_009300379.1
XP_073808755.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194419.1 → NP_919400.1  glutamate decarboxylase 1b

    See identical proteins and their annotated locations for NP_919400.1

    Status: PROVISIONAL

    Source sequence(s)
    BC047851
    UniProtKB/TrEMBL
    A0A286YBA0, Q5W8I4, Q7ZUS3
    Related
    ENSDARP00000024162.7, ENSDART00000003008.8
    Conserved Domains (1) summary
    pfam00282
    Location:137 → 511
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    4544205..4578574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009302104.5 → XP_009300379.1  glutamate decarboxylase 1b isoform X2

    UniProtKB/TrEMBL
    A0A2R8QPB1, A0A8M3B331
    Related
    ENSDARP00000157484.1
    Conserved Domains (1) summary
    pfam00282
    Location:116 → 490
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  2. XM_009302103.5 → XP_009300378.1  glutamate decarboxylase 1b isoform X1

    See identical proteins and their annotated locations for XP_009300378.1

    UniProtKB/TrEMBL
    A0A286YBA0, Q5W8I4, Q7ZUS3
    Related
    ENSDARP00000144468.1
    Conserved Domains (1) summary
    pfam00282
    Location:137 → 511
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  3. XM_073952654.1 → XP_073808755.1  glutamate decarboxylase 1b isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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