U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mafa MAF bZIP transcription factor A [ Mus musculus (house mouse) ]

Gene ID: 378435, updated on 27-Nov-2024

Summary

Official Symbol
Mafaprovided by MGI
Official Full Name
MAF bZIP transcription factor Aprovided by MGI
Primary source
MGI:MGI:2673307
See related
Ensembl:ENSMUSG00000047591 AllianceGenome:MGI:2673307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIPE3b1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including lens vesicle; myotome; nervous system; pancreas; and spleen. Used to study maturity-onset diabetes of the young and type 2 diabetes mellitus. Orthologous to human MAFA (MAF bZIP transcription factor A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mafa in Genome Data Viewer
Location:
15 D3; 15 34.82 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75617350..75620170, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75745501..75748321, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase 1, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E4136 Neighboring gene rhophilin, Rho GTPase binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10864 Neighboring gene zinc finger CCCH type containing 3 Neighboring gene predicted gene, 23747 Neighboring gene STARR-positive B cell enhancer ABC_E1911 Neighboring gene STARR-seq mESC enhancer starr_39021 Neighboring gene predicted gene, 34851

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transcription factor MafA
Names
Mafa homolog
V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
pancreatic beta-cell-specific transcriptional activator
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194350.2NP_919331.1  transcription factor MafA

    See identical proteins and their annotated locations for NP_919331.1

    Status: VALIDATED

    Source sequence(s)
    AC116393
    Consensus CDS
    CCDS27549.1
    UniProtKB/Swiss-Prot
    Q8CF90
    Related
    ENSMUSP00000054226.5, ENSMUST00000062002.6
    Conserved Domains (2) summary
    cd14718
    Location:255323
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:111142
    Maf_N; Maf N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75617350..75620170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)