Nanos2 nanos C2HC-type zinc finger 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nanos2provided by MGI
Official Full Name: nanos C2HC-type zinc finger 2provided by MGI
Primary source: MGI:MGI:2676627
See related: Ensembl:ENSMUSG00000051965 AllianceGenome:MGI:2676627
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: nos2
Summary: Enables mRNA binding activity. Involved in several processes, including germ-line stem cell population maintenance; mRNA catabolic process; and negative regulation of meiotic nuclear division. Located in P-body and perinuclear region of cytoplasm. Is expressed in early conceptus; gonad; mesonephros; and telencephalon. Orthologous to human NANOS2 (nanos C2HC-type zinc finger 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.45 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (18721449..18722887)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (18987524..18988962)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1.
Title: A cooperative mechanism of target RNA selection via germ-cell-specific RNA-binding proteins NANOS2 and DND1.
Genetic and structural analysis of the in vivo functional redundancy between murine NANOS2 and NANOS3.
Title: Genetic and structural analysis of the in vivo functional redundancy between murine NANOS2 and NANOS3.
Donor-derived spermatogenesis following stem cell transplantation in sterile NANOS2 knockout males.
Title: Donor-derived spermatogenesis following stem cell transplantation in sterile NANOS2 knockout males.
DDX6-null germ cells exhibited both similar and distinct defects from those observed in NANOS2-null germ cells. These results demonstrate that NANOS2 function is carried out via both P-body-dependent and -independent mechanisms. RNA-seq analyses further supported the phenotypic differences between DDX6-null and NANOS2-null germ cells, and indicated distinct molecular cascades involved in NANOS2-mediated gene regulation.
Title: ES-mediated chimera analysis revealed requirement of DDX6 for NANOS2 localization and function in mouse germ cells.
NANOS2 loss caused defects in both spermatogenesis and oogenesis and results in testicular teratoma incidence.
Title: Mouse dead end1 acts with Nanos2 and Nanos3 to regulate testicular teratoma incidence.
To determine the reprogramming potential of germ cell- specific genes, a polycistronic gene cassette expressing Stella, Oct4 and Nanos2 in a lentiviral-based vector, was designed.
Title: Suppression of dsRNA response genes and innate immunity following Oct4, Stella, and Nanos2 overexpression in mouse embryonic fibroblasts.
Data show that miR-34c up-regulated Nanos2 in mouse model of cryptorchidism.
Title: miR-34c disrupts spermatogonial stem cell homeostasis in cryptorchid testes by targeting Nanos2.
On the other hand, loss of NANOS2 results in the up-regulation of GFRA1 and PLZF, indicating a precocious entry of GST. Taken together, our data suggest that NANOS2 functions as an intrinsic timekeeper of GST in the mouse testes
Title: NANOS2 acts as an intrinsic regulator of gonocytes-to-spermatogonia transition in the murine testes.
DND1 interacts with NANOS2 to load unique RNAs into the CCR4-NOTdeaden complex; this interaction is mediated by the zinc finger domain of NANOS2, which is essential for its association with target RNAs; DND1 is an essential partner for NANOS2 that leads to the degradation of specific RNAs in male germ cell development
Title: Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development.
show that Nanos2, an evolutionarily conserved RNA-binding protein, works with other cellular messenger ribonucleoprotein (mRNP) components to ensure the primitive status of spermatogonial stem cells
Title: RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (15) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nanos2 (e-PCR), detects polymorphism
- UniSTS:546881

NoName (e-PCR)
- UniSTS:489564

Nanos2 (e-PCR), detects polymorphism
- UniSTS:498791

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell quiescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA destabilization	IEA Inferred from Electronic Annotation more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in oogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nanos homolog 2

Names: NOS-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.