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Nlrp12 NLR family, pyrin domain containing 12 [ Mus musculus (house mouse) ]

Gene ID: 378425, updated on 31-Jan-2019

Summary

Official Symbol
Nlrp12provided by MGI
Official Full Name
NLR family, pyrin domain containing 12provided by MGI
Primary source
MGI:MGI:2676630
See related
Ensembl:ENSMUSG00000078817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nalp12; PYPAF7; monarch-1
Expression
Biased expression in liver E18 (RPKM 1.8), liver adult (RPKM 0.8) and 2 other tissues See more
Orthologs

Genomic context

See Nlrp12 in Genome Data Viewer
Location:
7; 7 A1
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (3219495..3250159, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (3221511..3249741, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 7, ERATO Doi 143, expressed Neighboring gene microRNA 291a Neighboring gene microRNA 292b Neighboring gene microRNA 291b Neighboring gene microRNA 292 Neighboring gene microRNA 293 Neighboring gene microRNA 294 Neighboring gene microRNA 295 Neighboring gene olfactory receptor GA_x5J8B7W3939-136239-135295 Neighboring gene acidic ribosomal phosphoprotein P0 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to cytokine stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of Toll signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-1 secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interleukin-6 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MHC class I biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MHC class I biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
NOT nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NACHT, LRR and PYD domains-containing protein 12
Names
PYRIN-containing APAF1-like protein 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033431.1NP_001028603.1  NACHT, LRR and PYD domains-containing protein 12

    See identical proteins and their annotated locations for NP_001028603.1

    Status: VALIDATED

    Source sequence(s)
    CAAA01093162, CAAA01093166, CAAA01193276
    Consensus CDS
    CCDS51963.1
    UniProtKB/Swiss-Prot
    E9Q5R7
    Related
    ENSMUSP00000104293.2, ENSMUST00000108653.3
    Conserved Domains (7) summary
    smart00382
    Location:211307
    AAA; ATPases associated with a variety of cellular activities
    COG4886
    Location:704906
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:7371028
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:708736
    LRR_RI; leucine-rich repeat [structural motif]
    pfam02758
    Location:1190
    PYRIN; PAAD/DAPIN/Pyrin domain
    pfam05729
    Location:211380
    NACHT; NACHT domain
    pfam14484
    Location:129200
    FISNA; Fish-specific NACHT associated domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    3219495..3250159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540131.3XP_006540194.1  NACHT, LRR and PYD domains-containing protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006540194.1

    Conserved Domains (7) summary
    smart00382
    Location:184280
    AAA; ATPases associated with a variety of cellular activities
    COG4886
    Location:677879
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:7101001
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:681709
    LRR_RI; leucine-rich repeat [structural motif]
    pfam02758
    Location:1190
    PYRIN; PAAD/DAPIN/Pyrin domain
    pfam05729
    Location:184353
    NACHT; NACHT domain
    pfam14484
    Location:102173
    FISNA; Fish-specific NACHT associated domain
  2. XM_017322321.1XP_017177810.1  NACHT, LRR and PYD domains-containing protein 12 isoform X2

RNA

  1. XR_881738.2 RNA Sequence

Reference GRCm38.p4 PATCHES

Genomic

  1. NW_004058052.1 Reference GRCm38.p4 PATCHES

    Range
    220184..248370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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