U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LMP-1 latent membrane protein LMP-1 [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

Gene ID: 3783750, updated on 13-Apr-2025
Gene symbol
LMP-1
Gene description
latent membrane protein LMP-1
Locus tag
HHV4_LMP-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
Lineage
Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_007605.1 (166483..169088, complement)

NC_007605.1Genomic Context describing neighboring genes Neighboring gene apoptosis regulator BALF1 Neighboring gene protein BARF1 Neighboring gene membrane protein LMP-2A Neighboring gene protein BNLF2b Neighboring gene protein BNLF2a Neighboring gene membrane protein LMP-2B

Genomic Sequence:
NC_007605.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Targeting the lateral interactions of transmembrane domain 5 of Epstein-Barr virus latent membrane protein 1. Wang X, et al. Biochim Biophys Acta, 2012 Sep. PMID 22609737, Free PMC Article
  2. Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L. Yang GD, et al. PLoS One, 2013. PMID 24194922, Free PMC Article
  3. High molecular weight complex analysis of Epstein-Barr virus Latent Membrane Protein 1 (LMP-1): structural insights into LMP-1's homo-oligomerization and lipid raft association. Wrobel CM, et al. Virus Res, 2013 Dec 26. PMID 24075898, Free PMC Article
  4. Epstein-barr virus latent membrane protein 1 polymorphism in nasopharyngeal carcinoma and other oral cavity tumors in Russia. Senyuta N, et al. J Med Virol, 2014 Feb. PMID 24009107
  5. NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1. Ersing I, et al. Viruses, 2013 Jun 21. PMID 23793113, Free PMC Article

See all (266) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Assembly and activation of EBV latent membrane protein 1.
    Title: Assembly and activation of EBV latent membrane protein 1.
  2. Epstein-Barr virus LMP1 enhances levels of large extracellular vesicle-associated PD-L1.
    Title: Epstein-Barr virus LMP1 enhances levels of large extracellular vesicle-associated PD-L1.
  3. Genetic variability and mutation of Epstein-Barr virus (EBV)-encoded LMP-1 and BHRF-1 genes in EBV-infected patients: identification of precise targets for development of personalized EBV vaccines.
    Title: Genetic variability and mutation of Epstein‒Barr virus (EBV)-encoded LMP-1 and BHRF-1 genes in EBV-infected patients: identification of precise targets for development of personalized EBV vaccines.
  4. Mutations in latent membrane protein 1 of Epstein-Barr virus are associated with increased risk of posttransplant lymphoproliferative disorder in children.
    Title: Mutations in latent membrane protein 1 of Epstein-Barr virus are associated with increased risk of posttransplant lymphoproliferative disorder in children.
  5. STIM1-regulated exosomal EBV-LMP1 empowers endothelial cells with an aggressive phenotype by activating the Akt/ERK pathway in nasopharyngeal carcinoma.
    Title: STIM1-regulated exosomal EBV-LMP1 empowers endothelial cells with an aggressive phenotype by activating the Akt/ERK pathway in nasopharyngeal carcinoma.
  6. Epstein-Barr virus LMP1 protein promotes proliferation and inhibits differentiation of epithelial cells via activation of YAP and TAZ.
    Title: Epstein-Barr virus LMP1 protein promotes proliferation and inhibits differentiation of epithelial cells via activation of YAP and TAZ.
  7. LMP1 mediates tumorigenesis through persistent epigenetic modifications and PGC1beta upregulation.
    Title: LMP1 mediates tumorigenesis through persistent epigenetic modifications and PGC1β upregulation.
  8. Latent membrane protein 1 and macrophage-derived TNFalpha synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma.
    Title: Latent membrane protein 1 and macrophage-derived TNFα synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma.
  9. Repression of DERL3 via DNA methylation by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma.
    Title: Repression of DERL3 via DNA methylation by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma.
  10. Latent Membrane Protein 1 (LMP1) from Epstein-Barr Virus (EBV) Strains M81 and B95.8 Modulate miRNA Expression When Expressed in Immortalized Human Nasopharyngeal Cells.
    Title: Latent Membrane Protein 1 (LMP1) from Epstein-Barr Virus (EBV) Strains M81 and B95.8 Modulate miRNA Expression When Expressed in Immortalized Human Nasopharyngeal Cells.
Submit: New GeneRIF Correction See all GeneRIFs (254)
Products Interactant Other Gene Complex Source Pubs Description

regulatory

  • Loc: c166488-166483 regulatory_class = polyA_signal_sequence
  • Loc: c166492-166487 regulatory_class = polyA_signal_sequence
  • Loc: c167067-167062 regulatory_class = TATA_box
  • Loc: c168743-168738 regulatory_class = TATA_box
  • Loc: c169088-169083 regulatory_class = TATA_box
Preferred Names
latent membrane protein LMP-1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007605.1 Reference assembly

    Range
    166483..169088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_401722.1 latent membrane protein LMP-1 [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401722.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03230, Q777A4
    UniProtKB/TrEMBL
    A0A0B6VKE3, A0A0C7TBX2
    Conserved Domains (2) summary
    PHA02644
    Location:253 → 300
    PHA02644; hypothetical protein; Provisional
    pfam05297
    Location:1 → 386
    Herpes_LMP1; Herpesvirus latent membrane protein 1 (LMP1)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.