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KCNN4 potassium calcium-activated channel subfamily N member 4 [ Homo sapiens (human) ]

Gene ID: 3783, updated on 22-Aug-2020

Summary

Official Symbol
KCNN4provided by HGNC
Official Full Name
potassium calcium-activated channel subfamily N member 4provided by HGNC
Primary source
HGNC:HGNC:6293
See related
Ensembl:ENSG00000104783 MIM:602754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IK; IK1; SK4; DHS2; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1
Summary
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
Expression
Biased expression in salivary gland (RPKM 25.8), stomach (RPKM 13.6) and 10 other tissues See more
Orthologs

Genomic context

See KCNN4 in Genome Data Viewer
Location:
19q13.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43766533..43782139, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44270685..44286269, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene immunity related GTPase cinema Neighboring gene SMG9 nonsense mediated mRNA decay factor Neighboring gene CRISPRi-validated cis-regulatory element chr19.4589 Neighboring gene Sharpr-MPRA regulatory region 14970

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Dehydrated hereditary stomatocytosis 2
MedGen: C4225242 OMIM: 616689 GeneReviews: Not available
Compare labs
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Intermediate conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium channel activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
small conductance calcium-activated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
cell volume homeostasis IEA
Inferred from Electronic Annotation
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid translocation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
saliva secretion IEA
Inferred from Electronic Annotation
more info
 
stabilization of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
voltage-gated potassium channel complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
intermediate conductance calcium-activated potassium channel protein 4
Names
SKCa 4
SKCa4
potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
putative Gardos channel
putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel
small conductance calcium-activated potassium channel 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052672.1 RefSeqGene

    Range
    6167..20607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002250.3NP_002241.1  intermediate conductance calcium-activated potassium channel protein 4

    See identical proteins and their annotated locations for NP_002241.1

    Status: REVIEWED

    Source sequence(s)
    AF022797, AF033021
    Consensus CDS
    CCDS12630.1
    UniProtKB/Swiss-Prot
    O15554
    Related
    ENSP00000496939.1, ENST00000648319.1
    Conserved Domains (3) summary
    smart01053
    Location:304376
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:15122
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:237290
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43766533..43782139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258882.2XP_005258939.1  intermediate conductance calcium-activated potassium channel protein 4 isoform X1

    Conserved Domains (3) summary
    smart01053
    Location:272344
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:1590
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:205258
    Ion_trans_2; Ion channel
  2. XM_005258883.2XP_005258940.1  intermediate conductance calcium-activated potassium channel protein 4 isoform X2

    Related
    ENSP00000485014.1, ENST00000615047.4
    Conserved Domains (2) summary
    smart01053
    Location:241313
    CaMBD; Calmodulin binding domain
    pfam07885
    Location:174227
    Ion_trans_2; Ion channel

RNA

  1. XR_935823.1 RNA Sequence

  2. XR_002958313.1 RNA Sequence

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