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TRIM74 tripartite motif containing 74 [ Homo sapiens (human) ]

Gene ID: 378108, updated on 5-Aug-2022

Summary

Official Symbol
TRIM74provided by HGNC
Official Full Name
tripartite motif containing 74provided by HGNC
Primary source
HGNC:HGNC:17453
See related
Ensembl:ENSG00000155428 MIM:612550; AllianceGenome:HGNC:17453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRIM50C
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 13.0), bone marrow (RPKM 5.7) and 24 other tissues See more
Orthologs
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Genomic context

See TRIM74 in Genome Data Viewer
Location:
7q11.23
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (72954868..72969681, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (74187710..74197691, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (72430016..72439997, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene speedy/RINGO cell cycle regulator family member E7, pseudogene Neighboring gene POM121 transmembrane nucleoporin Neighboring gene uncharacterized LOC124901671 Neighboring gene NSUN5 pseudogene 2 Neighboring gene FKBP prolyl isomerase 6 pseudogene Neighboring gene uncharacterized LOC124901672 Neighboring gene stromal antigen 3-like 3 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45440

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 74
Names
tripartite motif-containing 50C
tripartite motif-containing protein 50C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317815.2NP_001304744.1  tripartite motif-containing protein 74

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF498999, BC033871
    Consensus CDS
    CCDS5545.1
    UniProtKB/Swiss-Prot
    B7WP46, Q86UV6
    Conserved Domains (2) summary
    cd00021
    Location:90125
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1560
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. NM_198853.3NP_942150.1  tripartite motif-containing protein 74

    See identical proteins and their annotated locations for NP_942150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF498999, BC033871
    Consensus CDS
    CCDS5545.1
    UniProtKB/Swiss-Prot
    B7WP46, Q86UV6
    Related
    ENSP00000285805.3, ENST00000285805.3
    Conserved Domains (2) summary
    cd00021
    Location:90125
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1560
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    72954868..72969681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420354.1XP_047276310.1  tripartite motif-containing protein 74 isoform X4

  2. XM_011516190.3XP_011514492.1  tripartite motif-containing protein 74 isoform X3

    See identical proteins and their annotated locations for XP_011514492.1

    Conserved Domains (1) summary
    cd00021
    Location:3671
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
  3. XM_047420352.1XP_047276308.1  tripartite motif-containing protein 74 isoform X3

  4. XM_047420355.1XP_047276311.1  tripartite motif-containing protein 74 isoform X4

  5. XM_047420353.1XP_047276309.1  tripartite motif-containing protein 74 isoform X3

  6. XM_011516187.4XP_011514489.1  tripartite motif-containing protein 74 isoform X1

    See identical proteins and their annotated locations for XP_011514489.1

    UniProtKB/Swiss-Prot
    B7WP46, Q86UV6
    Conserved Domains (2) summary
    cd00021
    Location:90125
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1560
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  7. XM_047420356.1XP_047276312.1  tripartite motif-containing protein 74 isoform X5

  8. XM_047420350.1XP_047276306.1  tripartite motif-containing protein 74 isoform X2

  9. XM_011516189.3XP_011514491.1  tripartite motif-containing protein 74 isoform X2

    See identical proteins and their annotated locations for XP_011514491.1

    UniProtKB/Swiss-Prot
    Q86UV6
    Related
    ENSP00000378665.1, ENST00000395244.5
    Conserved Domains (2) summary
    cd00021
    Location:90125
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd00162
    Location:1560
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    74187710..74197691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)