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KCNN2 potassium calcium-activated channel subfamily N member 2 [ Homo sapiens (human) ]

Gene ID: 3781, updated on 8-Dec-2018

Summary

Official Symbol
KCNN2provided by HGNC
Official Full Name
potassium calcium-activated channel subfamily N member 2provided by HGNC
Primary source
HGNC:HGNC:6291
See related
Ensembl:ENSG00000080709 MIM:605879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SK2; hSK2; SKCA2; KCa2.2; SKCa 2
Summary
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Expression
Biased expression in adrenal (RPKM 4.9), liver (RPKM 3.5) and 8 other tissues See more
Orthologs

Genomic context

See KCNN2 in Genome Data Viewer
Location:
5q22.3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (114056006..114496500)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (113698016..113832197)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986441 Neighboring gene uncharacterized LOC105379127 Neighboring gene RNA, 7SK small nuclear pseudogene 89 Neighboring gene uncharacterized LOC101927078 Neighboring gene long intergenic non-protein coding RNA 1957 Neighboring gene tripartite motif containing 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Ca2+ activated K+ channels, organism-specific biosystem (from REACTOME)
    Ca2+ activated K+ channels, organism-specific biosystemCa2+ activated potassium channels are expressed in neuronal and non-neuronal tissue such as smooth muscle, epithelial cell and sensory cells. Ca2+ activated potassium channels are activated when the ...
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-actinin binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
small conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small conductance calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
small conductance calcium-activated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
small conductance calcium-activated potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
small conductance calcium-activated potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
membrane repolarization during atrial cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
potassium ion transport NAS
Non-traceable Author Statement
more info
PubMed 
regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Z disc ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
small conductance calcium-activated potassium channel protein 2
Names
apamin-sensitive small-conductance Ca2+-activated potassium channel
potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
small conductance calcium-activated potassium channel 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278204.1NP_001265133.1  small conductance calcium-activated potassium channel protein 2 isoform b

    See identical proteins and their annotated locations for NP_001265133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (b), which is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AF239613, AK289948, BC015371, BG769522
    Consensus CDS
    CCDS43352.1
    UniProtKB/Swiss-Prot
    Q9H2S1
    Related
    ENSP00000483124.1, ENST00000610748.4
    Conserved Domains (2) summary
    pfam02888
    Location:64136
    CaMBD; Calmodulin binding domain
    pfam07885
    Location:150
    Ion_trans_2; Ion channel
  2. NM_021614.3NP_067627.2  small conductance calcium-activated potassium channel protein 2 isoform a

    See identical proteins and their annotated locations for NP_067627.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF239613, AK289948, BC015371, BC117454
    Consensus CDS
    CCDS4114.1
    UniProtKB/Swiss-Prot
    Q9H2S1
    Related
    ENSP00000264773.2, ENST00000264773.7
    Conserved Domains (3) summary
    smart01053
    Location:412487
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:124231
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:319398
    Ion_trans_2; Ion channel
  3. NM_170775.2NP_740721.1  small conductance calcium-activated potassium channel protein 2 isoform b

    See identical proteins and their annotated locations for NP_740721.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (b), which is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    BC015371, BG477734
    Consensus CDS
    CCDS43352.1
    UniProtKB/Swiss-Prot
    Q9H2S1
    Related
    ENSP00000421439.1, ENST00000503706.5
    Conserved Domains (2) summary
    pfam02888
    Location:64136
    CaMBD; Calmodulin binding domain
    pfam07885
    Location:150
    Ion_trans_2; Ion channel

RNA

  1. NR_103458.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' exon structure and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC015371, BC040722, BG477734

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    114056006..114496500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543387.1XP_011541689.1  small conductance calcium-activated potassium channel protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011541689.1

    Conserved Domains (3) summary
    smart01053
    Location:690765
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:402509
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:597676
    Ion_trans_2; Ion channel
  2. XM_011543389.1XP_011541691.1  small conductance calcium-activated potassium channel protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011541691.1

    Related
    ENSP00000427120.4, ENST00000512097.8
    Conserved Domains (3) summary
    smart01053
    Location:690765
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:402509
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:597676
    Ion_trans_2; Ion channel
  3. XM_017009457.1XP_016864946.1  small conductance calcium-activated potassium channel protein 2 isoform X2

    Conserved Domains (2) summary
    pfam02888
    Location:108180
    CaMBD; Calmodulin binding domain
    pfam07885
    Location:2494
    Ion_trans_2; Ion channel
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