Galphas G protein alpha subunit s [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Galphasprovided by FlyBase
Official Full Name: G protein alpha subunit sprovided by FlyBase
Primary source: FLYBASE:FBgn0001123
Locus tag: Dmel_CG2835
See related: AllianceGenome:FB:FBgn0001123
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2835; dgs; DGs; dgsalpha; DGsalpha; dG[[alphas]]; Dmel\CG2835; G-5alpha; G-alpha-60A; G-salpha 60A; G-salpha60A; Gaalpha; Galpha60A; galphas; GalphaS; Galphas60A; Galpha[[s]]; Galpha[[s]]60A; GNAS/L; Gs; Gs-alpha; Gs-alpha60A; Gsalpha; GSalpha; Gsalpha60; Gsalpha60A; G[[alphas]]; G[[s]]; G[[s]]-alpha-60A; G[[s]]alpha; G[[S]]alpha
Summary: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including positive regulation of feeding behavior; response to trehalose; and sensory perception of sweet taste. Located in basement membrane and plasma membrane. Part of heterotrimeric G-protein complex. Is active in neuromuscular junction; postsynapse; and presynapse. Is expressed in several structures, including chemosensory sensory organ; embryonic/larval midgut primordium; gut section; larval muscle cell; and organism subdivision. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; McCune Albright syndrome; dystonia 25; pituitary adenoma 3; and pseudohypoparathyroidism (multiple). Orthologous to several human genes including GNAL (G protein subunit alpha L). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: 60A12-60A13; 2-105 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23942538..23946936)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19830061..19834459)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study observed an unexpected and significant Galphas -dependent increase in cAMP levels in response to strong Smo activation in Smo-transfected cells.
Title: Activation of Smoothened in the Hedgehog pathway unexpectedly increases Gα(s)-dependent cAMP levels in Drosophila.
dgsR60 mutant synaptic transmission defects were caused predominantly by lack of Gs(alpha) in presynaptic neurons and not in postsynaptic muscles
Title: Presynaptic impairment of synaptic transmission in Drosophila embryos lacking Gs(alpha).
DGsalpha is involved in trehalose perception. We suggest that sugar-taste signals are processed through the Gsalpha-mediating signal transduction pathway in sugar-sensitive GRNs in Drosophila.
Title: Gsalpha is involved in sugar perception in Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein activity	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in behavioral response to cocaine	NAS Non-traceable Author Statement more info	PubMed
involved_in cell junction organization	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in instar larval or pupal development	NAS Non-traceable Author Statement more info	PubMed
involved_in learning or memory	NAS Non-traceable Author Statement more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of feeding behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to trehalose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of chemical stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sweet taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in visual behavior	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: G protein alpha subunit s

Names: CG2835-PA; CG2835-PB; CG2835-PC; CG2835-PD; CG2835-PE; G protein alpha s subunit; G protein salpha 60A; G-alpha s; Galphas-PA; Galphas-PB; Galphas-PC; Galphas-PD; Galphas-PE; Gs small G protein subunit; stimulatory alpha subunit of G protein

NP_001163283.1

unusual splice

NP_477505.1

unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

23942538..23946936

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058157.5 → NP_477505.1 G protein alpha subunit s, isoform B

See identical proteins and their annotated locations for NP_477505.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JGV3, P20354, P20355, Q2MGN1, Q9W1F9

Related

FBpp0072052

Conserved Domains (1) summary

cd00066
Location:44 → 379

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_058158.5 → NP_477506.1 G protein alpha subunit s, isoform A

See identical proteins and their annotated locations for NP_477506.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGI1

Related

FBpp0072053

Conserved Domains (1) summary

cd00066
Location:44 → 376

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_001169812.2 → NP_001163283.1 G protein alpha subunit s, isoform D

See identical proteins and their annotated locations for NP_001163283.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JGV3, P20354, P20355, Q2MGN1, Q9W1F9

Conserved Domains (1) summary

cd00066
Location:44 → 379

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_166640.3 → NP_726388.1 G protein alpha subunit s, isoform C

See identical proteins and their annotated locations for NP_726388.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGI1

Related

FBpp0072051

Conserved Domains (1) summary

cd00066
Location:44 → 376

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_001299869.1 → NP_001286798.1 G protein alpha subunit s, isoform E

See identical proteins and their annotated locations for NP_001286798.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGI1

Conserved Domains (1) summary

cd00066
Location:44 → 376

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)