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ARF3 ARF GTPase 3 [ Homo sapiens (human) ]

Gene ID: 377, updated on 9-Jun-2025
Official Symbol
ARF3provided by HGNC
Official Full Name
ARF GTPase 3provided by HGNC
Primary source
HGNC:HGNC:654
See related
Ensembl:ENSG00000134287 MIM:103190; AllianceGenome:HGNC:654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. [provided by RefSeq, Oct 2022]
Expression
Ubiquitous expression in brain (RPKM 69.0), colon (RPKM 28.8) and 24 other tissues See more
Orthologs
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See ARF3 in Genome Data Viewer
Location:
12q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48935723..48957487, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48892453..48919687, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49329506..49351270, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4414 Neighboring gene ribosomal protein L32 pseudogene 27 Neighboring gene dynein regulatory complex subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6296 Neighboring gene FKBP prolyl isomerase 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4415 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49338542-49339042 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:49340991-49341204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49341223-49341815 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49349467-49350462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6297 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:49353706-49353915 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:49358123-49358716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49360112-49360664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49361393-49362276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4416 Neighboring gene Sharpr-MPRA regulatory region 4091 Neighboring gene Wnt family member 10B

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin. Tsai SC, et al. J Biol Chem, 1991 Dec 5. PMID 1744102
  2. Neurodevelopmental disorder associated with gene ARF3: A case report. Dos Santos Henrique S, et al. Am J Med Genet A, 2024 Sep. PMID 38712921
  3. Heregulin promotes expression and subcellular redistribution of ADP-ribosylation factor 3. Li F, et al. FEBS Lett, 2002 Jul 31. PMID 12135740
  4. Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors. Manolea F, et al. Mol Biol Cell, 2010 Jun 1. PMID 20357002, Free PMC Article
  5. Characterization of the human ADP-ribosylation factor 3 promoter. Transcriptional regulation of a TATA-less promoter. Haun RS, et al. J Biol Chem, 1993 Apr 25. PMID 8473323

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels.
    Title: The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels.
  2. Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish.
    Title: Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish.
  3. Upregulation of ARF3 is associated with ovarian cancer.
    Title: Overexpression of ARF1 is associated with cell proliferation and migration through PI3K signal pathway in ovarian cancer.
  4. observations indicate that Arf1 and Arf3 as well as Arf6 play important roles in cytokinesis.
    Title: Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis.
  5. activated ARF3 is associated with Unc93B1 and TLR9, suggesting that ARF3 conducts TLR9 trafficking by forming the TLR9-Unc93B1-ARF3 complex.
    Title: ADP-Ribosylation Factor 3 Mediates Cytidine-Phosphate-Guanosine Oligodeoxynucleotide-Induced Responses by Regulating Toll-Like Receptor 9 Trafficking.
  6. ARF1+ARF3 are required for integrity of recycling endosomes but are involved in distinct transport pathways: they are required for the transferrin recycling pathway from endosomes to the plasma membrane.
    Title: ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.
  7. ARF1 and ARF3 are redundantly required for the integrity of recycling endosomes
    Title: ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.
  8. These results suggest that Arf3 plays a unique function at the trans-Golgi network that likely involves recruitment by a specific receptor.
    Title: Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors.
  9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding TAS
Traceable Author Statement
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
ADP-ribosylation factor 3
Names
ADP ribosylation factor 3
small GTP binding protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412914.1 → NP_001399843.1  ADP-ribosylation factor 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC073610
    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9

  2. NM_001412915.1 → NP_001399844.1  ADP-ribosylation factor 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC073610
    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9

  3. NM_001412916.1 → NP_001399845.1  ADP-ribosylation factor 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC073610
    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9

  4. NM_001412918.1 → NP_001399847.1  ADP-ribosylation factor 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC073610
    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9

  5. NM_001412920.1 → NP_001399849.1  ADP-ribosylation factor 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC073610
    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9

  6. NM_001412926.1 → NP_001399855.1  ADP-ribosylation factor 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC073610
    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9

  7. NM_001412928.1 → NP_001399857.1  ADP-ribosylation factor 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC073610
    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9

  8. NM_001412930.1 → NP_001399859.1  ADP-ribosylation factor 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC073610
    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9

  9. NM_001412931.1 → NP_001399860.1  ADP-ribosylation factor 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC073610
    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9

  10. NM_001412932.1 → NP_001399861.1  ADP-ribosylation factor 3 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC073610
    UniProtKB/TrEMBL
    B4E190
    Related
    ENSP00000395370.2, ENST00000447318.6

  11. NM_001659.3 → NP_001650.1  ADP-ribosylation factor 3 isoform a

    See identical proteins and their annotated locations for NP_001650.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AC073610
    Consensus CDS
    CCDS8774.1
    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9
    Related
    ENSP00000256682.4, ENST00000256682.9
    Conserved Domains (1) summary
    cl38936
    Location:5 → 179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    48935723..48957487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448972.2 → XP_024304740.1  ADP-ribosylation factor 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9
    Conserved Domains (1) summary
    cl38936
    Location:5 → 179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    48892453..48919687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372007.1 → XP_054227982.1  ADP-ribosylation factor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TNZ0

  2. XM_054372006.1 → XP_054227981.1  ADP-ribosylation factor 3 isoform X1

    UniProtKB/Swiss-Prot
    A8K6G8, B7ZB63, P16587, P61204
    UniProtKB/TrEMBL
    B4DEB9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61204.2 GenPept UniProtKB/Swiss-Prot:P61204

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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