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ARF3 ADP ribosylation factor 3 [ Homo sapiens (human) ]

Gene ID: 377, updated on 5-Dec-2021

Summary

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Official Symbol
ARF3provided by HGNC
Official Full Name
ADP ribosylation factor 3provided by HGNC
Primary source
HGNC:HGNC:654
See related
Ensembl:ENSG00000134287 MIM:103190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. The ARF3 gene contains five exons and four introns. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 69.0), colon (RPKM 28.8) and 24 other tissues See more
Orthologs
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Genomic context

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See ARF3 in Genome Data Viewer
Location:
12q13.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (48930252..48957526, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49329506..49351270, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 65 Neighboring gene FKBP prolyl isomerase 11 Neighboring gene Wnt family member 10B Neighboring gene RNA, U6 small nuclear 940, pseudogene Neighboring gene uncharacterized LOC105369757 Neighboring gene Wnt family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors. Manolea F, et al. Mol Biol Cell, 2010 Jun 1. PMID 20357002, Free PMC Article
  2. Heregulin promotes expression and subcellular redistribution of ADP-ribosylation factor 3. Li F, et al. FEBS Lett, 2002 Jul 31. PMID 12135740
  3. Characterization of the human ADP-ribosylation factor 3 promoter. Transcriptional regulation of a TATA-less promoter. Haun RS, et al. J Biol Chem, 1993 Apr 25. PMID 8473323
  4. Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin. Tsai SC, et al. J Biol Chem, 1991 Dec 5. PMID 1744102
  5. Overexpression of ARF1 is associated with cell proliferation and migration through PI3K signal pathway in ovarian cancer. Gu G, et al. Oncol Rep, 2017 Mar. PMID 28098897

See all (82) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of ARF3 is associated with ovarian cancer.
    Title: Overexpression of ARF1 is associated with cell proliferation and migration through PI3K signal pathway in ovarian cancer.
  2. observations indicate that Arf1 and Arf3 as well as Arf6 play important roles in cytokinesis.
    Title: Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis.
  3. activated ARF3 is associated with Unc93B1 and TLR9, suggesting that ARF3 conducts TLR9 trafficking by forming the TLR9-Unc93B1-ARF3 complex.
    Title: ADP-Ribosylation Factor 3 Mediates Cytidine-Phosphate-Guanosine Oligodeoxynucleotide-Induced Responses by Regulating Toll-Like Receptor 9 Trafficking.
  4. ARF1+ARF3 are required for integrity of recycling endosomes but are involved in distinct transport pathways: they are required for the transferrin recycling pathway from endosomes to the plasma membrane.
    Title: ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.
  5. ARF1 and ARF3 are redundantly required for the integrity of recycling endosomes
    Title: ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.
  6. These results suggest that Arf3 plays a unique function at the trans-Golgi network that likely involves recruitment by a specific receptor.
    Title: Arf3 is activated uniquely at the trans-Golgi network by brefeldin A-inhibited guanine nucleotide exchange factors.
  7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  9. expression and subcellular redistribution by heregulin
    Title: Heregulin promotes expression and subcellular redistribution of ADP-ribosylation factor 3.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
ADP-ribosylation factor 3
Names
small GTP binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001659.3 → NP_001650.1  ADP-ribosylation factor 3

    See identical proteins and their annotated locations for NP_001650.1

    Status: REVIEWED

    Source sequence(s)
    AC073610
    Consensus CDS
    CCDS8774.1
    UniProtKB/Swiss-Prot
    P61204
    UniProtKB/TrEMBL
    A0A024R0Y6
    Related
    ENSP00000256682.4, ENST00000256682.9
    Conserved Domains (1) summary
    cl38936
    Location:5 → 179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    48930252..48957526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719391.4 → XP_006719454.1  ADP-ribosylation factor 3 isoform X2

    Conserved Domains (1) summary
    cl40481
    Location:1 → 128
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  2. XM_005268856.1 → XP_005268913.1  ADP-ribosylation factor 3 isoform X1

    See identical proteins and their annotated locations for XP_005268913.1

    UniProtKB/Swiss-Prot
    P61204
    UniProtKB/TrEMBL
    A0A024R0Y6
    Conserved Domains (1) summary
    cl38936
    Location:5 → 179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_024448972.1 → XP_024304740.1  ADP-ribosylation factor 3 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:5 → 179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61204.2 GenPept UniProtKB/Swiss-Prot:P61204

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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