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KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 [ Homo sapiens (human) ]

Gene ID: 3779, updated on 9-Jun-2025
Official Symbol
KCNMB1provided by HGNC
Official Full Name
potassium calcium-activated channel subfamily M regulatory beta subunit 1provided by HGNC
Primary source
HGNC:HGNC:6285
See related
Ensembl:ENSG00000145936 MIM:603951; AllianceGenome:HGNC:6285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hbeta1; BKbeta1; SLO-BETA; hslo-beta; K(VCA)beta; slo-beta-1; k(VCA)beta-1
Summary
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 43.3), prostate (RPKM 41.0) and 15 other tissues See more
Orthologs
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See KCNMB1 in Genome Data Viewer
Location:
5q35.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (170374671..170389367, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (170913506..170928202, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (169801675..169816371, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23607 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:169757700-169758899 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:169759699-169760548 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:169760549-169761396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23610 Neighboring gene long intergenic non-protein coding RNA 1366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169788107-169788607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169814486-169814986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169814987-169815487 Neighboring gene potassium voltage-gated channel interacting protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169817412-169817912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169817913-169818413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169818666-169819166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169819167-169819667 Neighboring gene KCNIP1 overlapping transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:169865238-169866195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169911974-169912474 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:169913290-169913456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:169962091-169962591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:169979309-169979878 Neighboring gene MPRA-validated peak5573 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:170024020-170025219 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:170038765-170039501 Neighboring gene uncharacterized LOC124901132

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Associated conditions

Description Tests
HYPERTENSION, DIASTOLIC, RESISTANCE TO
MedGen: C1837739 OMIM: 608622 GeneReviews: Not available
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EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-activated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-activated potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in detection of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
calcium-activated potassium channel subunit beta-1
Names
BK channel beta subunit 1
BK channel subunit beta-1
MaxiK channel beta-subunit 1
big potassium channel beta subunit 1
calcium-activated potassium channel, subfamily M subunit beta-1
charybdotoxin receptor subunit beta-1
large conductance Ca2+-activated K+ channel beta 1 subunit
maxi K channel subunit beta-1
potassium channel subfamily M regulatory beta subunit 1
potassium large conductance calcium-activated channel, subfamily M, beta member 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011452.3 RefSeqGene

    Range
    5000..19696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004137.4NP_004128.1  calcium-activated potassium channel subunit beta-1

    See identical proteins and their annotated locations for NP_004128.1

    Status: REVIEWED

    Source sequence(s)
    AC134820
    Consensus CDS
    CCDS4373.1
    UniProtKB/Swiss-Prot
    O00707, O00708, P78475, Q16558, Q53YR0, Q8TAX3, Q93005
    Related
    ENSP00000274629.3, ENST00000274629.9
    Conserved Domains (1) summary
    pfam03185
    Location:7190
    CaKB; Calcium-activated potassium channel, beta subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    170374671..170389367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    170913506..170928202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)