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KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 [ Homo sapiens (human) ]

Gene ID: 3779, updated on 22-Aug-2020

Summary

Official Symbol
KCNMB1provided by HGNC
Official Full Name
potassium calcium-activated channel subfamily M regulatory beta subunit 1provided by HGNC
Primary source
HGNC:HGNC:6285
See related
Ensembl:ENSG00000145936 MIM:603951
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hbeta1; BKbeta1; SLO-BETA; hslo-beta; K(VCA)beta; slo-beta-1; k(VCA)beta-1
Summary
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 43.3), prostate (RPKM 41.0) and 15 other tissues See more
Orthologs

Genomic context

See KCNMB1 in Genome Data Viewer
Location:
5q35.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (170374671..170389367, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (169805165..169816681, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128059 Neighboring gene long intergenic non-protein coding RNA 1366 Neighboring gene potassium voltage-gated channel interacting protein 1 Neighboring gene KCNIP1 overlapping transcript 1 Neighboring gene KCNIP1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available
Hypertension, diastolic, resistance to
MedGen: C1837739 OMIM: 608622 GeneReviews: Not available
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Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
cellular response to bile acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to ethanol IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
detection of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of blood vessel diameter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calcium-activated potassium channel subunit beta-1
Names
BK channel beta subunit 1
BK channel subunit beta-1
MaxiK channel beta-subunit 1
big potassium channel beta subunit 1
calcium-activated potassium channel, subfamily M subunit beta-1
charybdotoxin receptor subunit beta-1
large conductance Ca2+-activated K+ channel beta 1 subunit
maxi K channel subunit beta-1
potassium channel subfamily M regulatory beta subunit 1
potassium large conductance calcium-activated channel, subfamily M, beta member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011452.2 RefSeqGene

    Range
    4958..16474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004137.4NP_004128.1  calcium-activated potassium channel subunit beta-1

    See identical proteins and their annotated locations for NP_004128.1

    Status: REVIEWED

    Source sequence(s)
    AC134820
    Consensus CDS
    CCDS4373.1
    UniProtKB/Swiss-Prot
    Q16558
    Related
    ENSP00000274629.3, ENST00000274629.9
    Conserved Domains (1) summary
    pfam03185
    Location:7190
    CaKB; Calcium-activated potassium channel, beta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    170374671..170389367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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