U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mtpbeta Mitochondrial trifunctional protein beta subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37784, updated on 26-Sep-2023

Summary

Go to the top of the page Help
Official Symbol
Mtpbetaprovided by FlyBase
Official Full Name
Mitochondrial trifunctional protein beta subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0025352
Locus tag
Dmel_CG4581
See related
AllianceGenome:FB:FBgn0025352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACoT; CG4581; dHADHB; Dmel\CG4581; l(2)k09828; MTP; thiolase; Thiolase
Summary
Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Involved in determination of adult lifespan and fatty acid beta-oxidation. Located in mitochondrion. Is expressed in several structures, including adult heart; embryonic dorsal epidermis; embryonic/larval fat body; germline cell; and gut section. Used to study fatty liver disease; lipid metabolism disorder; and mitochondrial trifunctional protein deficiency. Human ortholog(s) of this gene implicated in mitochondrial metabolism disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Mtpbeta in Genome Data Viewer
Location:
60A5-60A5; 2-105 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23866648..23868603, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19754171..19756126, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene TAR DNA-binding protein-43 homolog Neighboring gene Ceramide phosphoethanolamine synthase Neighboring gene uncharacterized protein Neighboring gene ken and barbie Neighboring gene Transmembrane 4 superfamily Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Neuron-specific knockdown of Drosophila HADHB induces a shortened lifespan, deficient locomotive ability, abnormal motor neuron terminal morphology and learning disability. Li J, et al. Exp Cell Res, 2019 Jun 15. PMID 30953623
  2. Impaired fatty acid oxidation in a Drosophila model of mitochondrial trifunctional protein (MTP) deficiency. Kishita Y, et al. Biochem Biophys Res Commun, 2012 Mar 9. PMID 22342726
  3. Identification of CR43467 encoding a long non-coding RNA as a novel genetic interactant with dFIG4, a CMT-causing gene. Shimada S, et al. Exp Cell Res, 2020 Jan 1. PMID 31704059
  4. Aging in the Drosophila ovary: contrasting changes in the expression of the piRNA machinery and mitochondria but no global release of transposable elements. Erwin AA, et al. BMC Genomics, 2019 Apr 23. PMID 31014230, Free PMC Article
  5. The ken and barbie gene encoding a putative transcription factor with a BTB domain and three zinc finger motifs functions in terminalia development of Drosophila. Lukacsovich T, et al. Arch Insect Biochem Physiol, 2003 Oct. PMID 14518006

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mitochondrial trifunctional protein beta subunit
Names
CG4581-PA
Mtpbeta-PA
thiolase
NP_477378.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23866648..23868603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058030.4 → NP_477378.1  mitochondrial trifunctional protein beta subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477378.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77466, Q9W1H8
    Related
    FBpp0072135, FBtr0072226
    Conserved Domains (2) summary
    PRK08963
    Location:44 → 462
    fadI; 3-ketoacyl-CoA thiolase; Reviewed
    cd00751
    Location:45 → 462
    thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77466 O77466
Q9W1H8 Q9W1H8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous