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KCNMA1 potassium calcium-activated channel subfamily M alpha 1 [ Homo sapiens (human) ]

Gene ID: 3778, updated on 1-Mar-2024

Summary

Official Symbol
KCNMA1provided by HGNC
Official Full Name
potassium calcium-activated channel subfamily M alpha 1provided by HGNC
Primary source
HGNC:HGNC:6284
See related
Ensembl:ENSG00000156113 MIM:600150; AllianceGenome:HGNC:6284
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLO; BKTM; SLO1; hSlo; IEG16; LIWAS; MaxiK; PNKD3; SAKCA; mSLO1; CADEDS; KCa1.1; SLO-ALPHA; bA205K10.1
Summary
This gene encodes the alpha subunit of calcium-activated BK channel. The encoded protein is involved in several physiological processes including smooth muscle contraction, neurotransmitter release and neuronal excitability. Mutations in this gene are associated with a spectrum of neurological disorders including Paroxysmal Nonkinesigenic Dyskinesia 3, Idiopathic Generalized Epilepsy 16 and Liang-Wang syndrome. [provided by RefSeq, Aug 2022]
Expression
Broad expression in endometrium (RPKM 7.1), brain (RPKM 4.7) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KCNMA1 in Genome Data Viewer
Location:
10q22.3
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (76869602..77637808, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (77738326..78506527, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (78629360..79397566, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene leucine rich melanocyte differentiation associated Neighboring gene uncharacterized LOC112268057 Neighboring gene Sharpr-MPRA regulatory region 6857 Neighboring gene VISTA enhancer hs1683 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:78192871-78193568 Neighboring gene VISTA enhancer hs1434 Neighboring gene Sharpr-MPRA regulatory region 3593 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:78383798-78384997 Neighboring gene VISTA enhancer hs748 Neighboring gene NANOG hESC enhancer GRCh37_chr10:78538831-78539723 Neighboring gene OCT4 hESC enhancer GRCh37_chr10:78568996-78569497 Neighboring gene NANOG hESC enhancer GRCh37_chr10:78582741-78583242 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 8 Neighboring gene uncharacterized LOC124902466 Neighboring gene KCNMA1 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:78733040-78734239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3609 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:78841288-78841844 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:78856955-78857142 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:78873963-78874931 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:78923175-78924374 Neighboring gene NANOG hESC enhancer GRCh37_chr10:78961027-78961555 Neighboring gene KCNMA1 antisense RNA 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79058612-79058814 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:79074042-79074589 Neighboring gene NANOG hESC enhancer GRCh37_chr10:79084628-79085170 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:79110032-79111231 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:79135632-79136831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79170031-79170530 Neighboring gene KCNMA1 antisense RNA 3 Neighboring gene uncharacterized LOC124902464 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:79291078-79292277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79305619-79306119 Neighboring gene H3K27ac hESC enhancers GRCh37_chr10:79324026-79324882 and GRCh37_chr10:79324883-79325737 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 15 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79352252-79352440 Neighboring gene uncharacterized LOC124902465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2517 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:79418700-79419899 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79432857-79433055 Neighboring gene RNA, 5S ribosomal pseudogene 321 Neighboring gene uncharacterized LOC105378372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3611 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79472357-79472588 Neighboring gene zinc finger protein 532 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cerebellar atrophy, developmental delay, and seizures
MedGen: C4539985 OMIM: 617643 GeneReviews: Not available
Compare labs
Epilepsy, idiopathic generalized, susceptibility to, 16
MedGen: C5231421 OMIM: 618596 GeneReviews: Not available
Compare labs
Generalized epilepsy-paroxysmal dyskinesia syndrome
MedGen: C5574945 OMIM: 609446 GeneReviews: Not available
Compare labs
Liang-Wang syndrome
MedGen: C5231479 OMIM: 618729 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
EBI GWAS Catalog
Genome wide association study identifies KCNMA1 contributing to human obesity.
EBI GWAS Catalog
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
EBI GWAS Catalog
Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC71881, DKFZp686K1437

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel subunit alpha-1
Names
BK channel alpha subunit
BKCA alpha subunit
big potassium channel alpha subunit
calcium-activated potassium channel, subfamily M subunit alpha-1
k(VCA)alpha
maxi-K channel HSLO
potassium channel, calcium activated large conductance subfamily M alpha, member 1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
slo homolog
slowpoke homolog
stretch-activated Kca channel

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012270.1 RefSeqGene

    Range
    5012..757938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014797.3NP_001014797.1  Calcium-activated potassium channel subunit alpha-1 isoform a

    See identical proteins and their annotated locations for NP_001014797.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AB209488, AC011439, BC024965, U09384
    UniProtKB/TrEMBL
    A0A1W2PNH9
    Related
    ENSP00000473714.2, ENST00000604624.6
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001161352.2NP_001154824.1  Calcium-activated potassium channel subunit alpha-1 isoform c

    See identical proteins and their annotated locations for NP_001154824.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (c) contains a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AB113382, AC011439, BC024965, BQ574058, U11058
    Consensus CDS
    CCDS60569.1
    UniProtKB/Swiss-Prot
    F8WA96, Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q5JQ23, Q5SQR9, Q96LG8, Q9UBB0, Q9UCX0, Q9UQK6
    UniProtKB/TrEMBL
    A0A1W2PQU4
    Related
    ENSP00000286628.8, ENST00000286628.14
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001161353.2NP_001154825.1  Calcium-activated potassium channel subunit alpha-1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (d) contains a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AB113575, AC011439, BC024965, BQ574058, U11058
    Consensus CDS
    CCDS53545.1
    UniProtKB/TrEMBL
    A0A1W2PQU4
    Related
    ENSP00000485867.1, ENST00000626620.3
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001271518.2NP_001258447.1  Calcium-activated potassium channel subunit alpha-1 isoform e

    See identical proteins and their annotated locations for NP_001258447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) omits an in-frame coding exon. The resulting isoform (e) is shorter compared to isoform a.
    Source sequence(s)
    AB209488, AB524033, AC011439, BC024965, BC137115
    Consensus CDS
    CCDS86106.1
    UniProtKB/TrEMBL
    A0A1W2PNH9, D5MRH1
    Related
    ENSP00000491555.1, ENST00000640807.1
    Conserved Domains (4) summary
    pfam00520
    Location:156342
    Ion_trans; Ion transport protein
    pfam03493
    Location:491579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:252337
    Ion_trans_2; Ion channel
    cl21454
    Location:356469
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. NM_001271519.2NP_001258448.1  Calcium-activated potassium channel subunit alpha-1 isoform f

    See identical proteins and their annotated locations for NP_001258448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (f) contains a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC011439, AC021032, AK024857, BC024965, BC144496
    Consensus CDS
    CCDS86116.1
    UniProtKB/TrEMBL
    A0A1W2PQU4, B7ZMF5
    Related
    ENSP00000491732.1, ENST00000639406.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. NM_001271520.2NP_001258449.1  Calcium-activated potassium channel subunit alpha-1 isoform short1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short1) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
    Source sequence(s)
    AL731556, BC009695, BC024965
    Consensus CDS
    CCDS73156.1
    UniProtKB/TrEMBL
    A0A087WZL8, Q6AI34
    Related
    ENSP00000482747.1, ENST00000618048.2
  7. NM_001271521.2NP_001258450.1  Calcium-activated potassium channel subunit alpha-1 isoform short2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short2) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
    Source sequence(s)
    BC009695, BC024965
    Consensus CDS
    CCDS60572.1
    UniProtKB/TrEMBL
    S4R453
    Related
    ENSP00000475086.1, ENST00000481070.1
  8. NM_001271522.2NP_001258451.1  Calcium-activated potassium channel subunit alpha-1 isoform short3

    See identical proteins and their annotated locations for NP_001258451.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short3) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
    Source sequence(s)
    AL731556, BC024965
    Consensus CDS
    CCDS60571.1
    UniProtKB/Swiss-Prot
    Q12791
    Related
    ENSP00000474686.1, ENST00000480683.2
  9. NM_001322829.2NP_001309758.1  Calcium-activated potassium channel subunit alpha-1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    UniProtKB/TrEMBL
    A0A1W2PPX7
    Related
    ENSP00000490978.1, ENST00000638991.1
  10. NM_001322830.2NP_001309759.1  Calcium-activated potassium channel subunit alpha-1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    Consensus CDS
    CCDS86121.1
    UniProtKB/TrEMBL
    A0A1W2PR56, A0A1W2PRG5
    Related
    ENSP00000492492.1, ENST00000638223.1
  11. NM_001322832.2NP_001309761.1  Calcium-activated potassium channel subunit alpha-1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    Consensus CDS
    CCDS81481.1
    UniProtKB/TrEMBL
    A0A1W2PQK5, H0Y382
    Related
    ENSP00000492005.1, ENST00000639486.1
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  12. NM_001322835.2NP_001309764.1  Calcium-activated potassium channel subunit alpha-1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    UniProtKB/TrEMBL
    H0Y382
    Related
    ENSP00000361498.6, ENST00000372421.10
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  13. NM_001322836.2NP_001309765.1  Calcium-activated potassium channel subunit alpha-1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    Consensus CDS
    CCDS86115.1
    UniProtKB/TrEMBL
    A0A1W2PP94, A0A1W2PQU4
    Related
    ENSP00000491418.1, ENST00000640141.1
  14. NM_001322837.2NP_001309766.1  Calcium-activated potassium channel subunit alpha-1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    UniProtKB/TrEMBL
    A0A1W2PQU4
    Related
    ENSP00000491166.1, ENST00000638754.1
  15. NM_001322838.2NP_001309767.1  Calcium-activated potassium channel subunit alpha-1 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC011439, AK310379, AL731575
    UniProtKB/TrEMBL
    A0A0A0MRC3
    Conserved Domains (4) summary
    pfam00520
    Location:30216
    Ion_trans; Ion transport protein
    pfam03493
    Location:365453
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:126211
    Ion_trans_2; Ion channel
    cl21454
    Location:230343
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  16. NM_001322839.2NP_001309768.1  Calcium-activated potassium channel subunit alpha-1 isoform short4

    Status: REVIEWED

    Source sequence(s)
    AL731556
  17. NM_001410940.1NP_001397869.1  Calcium-activated potassium channel subunit alpha-1 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
    Consensus CDS
    CCDS91276.1
    UniProtKB/TrEMBL
    A0A1W2PNH9, A0A1W2PSD3
    Related
    ENSP00000492806.1, ENST00000639601.1
  18. NM_002247.4NP_002238.2  Calcium-activated potassium channel subunit alpha-1 isoform b

    See identical proteins and their annotated locations for NP_002238.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (b) contains a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC011439, BC024965, BC137115, BQ574058, U11058, U13913
    Consensus CDS
    CCDS7352.1
    UniProtKB/TrEMBL
    A0A1W2PQU4
    Related
    ENSP00000286627.5, ENST00000286627.10
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    76869602..77637808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016222.3XP_016871711.2  calcium-activated potassium channel subunit alpha-1 isoform X41

    UniProtKB/TrEMBL
    A0A1W2PNQ3, H0Y382
    Related
    ENSP00000491008.1, ENST00000638306.1
    Conserved Domains (3) summary
    pfam00520
    Location:179387
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_024447990.2XP_024303758.1  calcium-activated potassium channel subunit alpha-1 isoform X40

    UniProtKB/TrEMBL
    A0A1W2PNW6, A0A1W2PNY9
    Related
    ENSP00000491123.1, ENST00000638203.1
    Conserved Domains (3) summary
    pfam00520
    Location:179387
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_024447989.2XP_024303757.1  calcium-activated potassium channel subunit alpha-1 isoform X39

    UniProtKB/TrEMBL
    A0A1W2PNY9, A0A1W2PQA0
    Related
    ENSP00000491981.1, ENST00000638606.1
    Conserved Domains (3) summary
    pfam00520
    Location:179387
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_005269787.5XP_005269844.1  calcium-activated potassium channel subunit alpha-1 isoform X36

    UniProtKB/TrEMBL
    A0A0A0MRR0, A0A1W2PPY5
    Related
    ENSP00000491673.1, ENST00000639090.1
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. XM_005269776.5XP_005269833.1  calcium-activated potassium channel subunit alpha-1 isoform X34

    UniProtKB/TrEMBL
    A0A0A0MRR0
    Related
    ENSP00000361480.4, ENST00000372403.9
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. XM_047425199.1XP_047281155.1  calcium-activated potassium channel subunit alpha-1 isoform X26

    UniProtKB/TrEMBL
    A0A1W2PPX7
  7. XM_005269792.3XP_005269849.1  calcium-activated potassium channel subunit alpha-1 isoform X25

    UniProtKB/TrEMBL
    A0A1W2PNH9
    Related
    ENSP00000385806.3, ENST00000404857.6
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  8. XM_024447984.2XP_024303752.1  calcium-activated potassium channel subunit alpha-1 isoform X18

    UniProtKB/TrEMBL
    A0A1W2PPX7, Q5SVJ9
    Related
    ENSP00000396608.2, ENST00000457953.6
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  9. XM_005269781.3XP_005269838.1  calcium-activated potassium channel subunit alpha-1 isoform X17

    UniProtKB/TrEMBL
    A0A1W2PNH9, A0A1W2PR62
    Related
    ENSP00000492075.1, ENST00000639544.1
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  10. XM_024447987.2XP_024303755.1  calcium-activated potassium channel subunit alpha-1 isoform X35

    UniProtKB/TrEMBL
    A0A1W2PRV4, Q5SVJ8
    Related
    ENSP00000385717.3, ENST00000404771.8
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  11. XM_011539785.3XP_011538087.1  calcium-activated potassium channel subunit alpha-1 isoform X37

    UniProtKB/TrEMBL
    H0Y382
    Related
    ENSP00000492718.1, ENST00000639205.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  12. XM_024447985.2XP_024303753.1  calcium-activated potassium channel subunit alpha-1 isoform X28

    UniProtKB/TrEMBL
    A0A1W2PQ61, H0Y382
    Related
    ENSP00000491927.1, ENST00000639489.1
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  13. XM_024447988.2XP_024303756.1  calcium-activated potassium channel subunit alpha-1 isoform X38

    UniProtKB/TrEMBL
    A0A1W2PPZ1, A0A1W2PRB0
    Related
    ENSP00000492510.1, ENST00000640182.1
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  14. XM_005269789.3XP_005269846.1  calcium-activated potassium channel subunit alpha-1 isoform X24

    UniProtKB/TrEMBL
    A0A1W2PRG5, Q5SVJ7
    Related
    ENSP00000361520.2, ENST00000372443.6
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  15. XM_005269778.3XP_005269835.1  calcium-activated potassium channel subunit alpha-1 isoform X16

    UniProtKB/TrEMBL
    A0A1W2PPX7, A0A1W2PRN5
    Related
    ENSP00000492414.1, ENST00000638848.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  16. XM_011539780.3XP_011538082.1  calcium-activated potassium channel subunit alpha-1 isoform X15

    UniProtKB/TrEMBL
    A0A1W2PNH9
    Related
    ENSP00000491539.1, ENST00000640934.1
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  17. XM_017016217.2XP_016871706.1  calcium-activated potassium channel subunit alpha-1 isoform X22

    UniProtKB/TrEMBL
    A0A1W2PQ93
  18. XM_017016213.3XP_016871702.1  calcium-activated potassium channel subunit alpha-1 isoform X13

    UniProtKB/TrEMBL
    A0A1W2PQ93
  19. XM_047425196.1XP_047281152.1  calcium-activated potassium channel subunit alpha-1 isoform X12

    UniProtKB/TrEMBL
    A0A1W2PNH9
  20. XM_011539775.3XP_011538077.1  calcium-activated potassium channel subunit alpha-1 isoform X7

    UniProtKB/TrEMBL
    A0A1W2PNH9
    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  21. XM_011539781.4XP_011538083.1  calcium-activated potassium channel subunit alpha-1 isoform X20

    UniProtKB/TrEMBL
    A0A1W2PNH9
    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  22. XM_017016211.3XP_016871700.1  calcium-activated potassium channel subunit alpha-1 isoform X10

    UniProtKB/TrEMBL
    A0A1W2PQ93
  23. XM_017016210.3XP_016871699.1  calcium-activated potassium channel subunit alpha-1 isoform X5

    UniProtKB/TrEMBL
    A0A1W2PPX7
  24. XM_011539773.3XP_011538075.1  calcium-activated potassium channel subunit alpha-1 isoform X4

    UniProtKB/TrEMBL
    A0A1W2PNH9
    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  25. XM_017016208.3XP_016871697.1  calcium-activated potassium channel subunit alpha-1 isoform X2

    UniProtKB/TrEMBL
    A0A1W2PPX7
  26. XM_017016207.3XP_016871696.1  calcium-activated potassium channel subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0A1W2PRG5
  27. XM_017016223.1XP_016871712.1  calcium-activated potassium channel subunit alpha-1 isoform X42

    UniProtKB/TrEMBL
    A0A0A0MRC3
    Conserved Domains (4) summary
    pfam00520
    Location:30216
    Ion_trans; Ion transport protein
    pfam03493
    Location:365453
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:126211
    Ion_trans_2; Ion channel
    cl21454
    Location:230343
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  28. XM_006717826.3XP_006717889.1  calcium-activated potassium channel subunit alpha-1 isoform X27

    UniProtKB/TrEMBL
    A0A1W2PQU4
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  29. XM_047425197.1XP_047281153.1  calcium-activated potassium channel subunit alpha-1 isoform X19

    UniProtKB/TrEMBL
    A0A1W2PQU4
    Related
    ENSP00000491300.1, ENST00000638283.1
  30. XM_011539778.3XP_011538080.1  calcium-activated potassium channel subunit alpha-1 isoform X9

    UniProtKB/TrEMBL
    A0A1W2PQU4
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  31. XM_011539783.3XP_011538085.1  calcium-activated potassium channel subunit alpha-1 isoform X23

    UniProtKB/TrEMBL
    A0A1W2PQU4
    Related
    ENSP00000490982.1, ENST00000639823.1
    Conserved Domains (3) summary
    pfam00520
    Location:179396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  32. XM_011539777.3XP_011538079.1  calcium-activated potassium channel subunit alpha-1 isoform X8

    UniProtKB/TrEMBL
    A0A1W2PQU4
    Conserved Domains (4) summary
    pfam00520
    Location:210396
    Ion_trans; Ion transport protein
    pfam03493
    Location:545633
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:306391
    Ion_trans_2; Ion channel
    cl21454
    Location:410523
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  33. XM_011539782.3XP_011538084.1  calcium-activated potassium channel subunit alpha-1 isoform X21

    UniProtKB/TrEMBL
    A0A1W2PQU4
    Related
    ENSP00000491840.1, ENST00000638514.1
    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  34. XM_017016214.3XP_016871703.1  calcium-activated potassium channel subunit alpha-1 isoform X14

    UniProtKB/TrEMBL
    A0A1W2PQU4
  35. XM_017016209.3XP_016871698.1  calcium-activated potassium channel subunit alpha-1 isoform X3

    UniProtKB/TrEMBL
    A0A1W2PQU4
  36. XM_047425195.1XP_047281151.1  calcium-activated potassium channel subunit alpha-1 isoform X11

    UniProtKB/TrEMBL
    A0A1W2PQU4
  37. XM_011539774.3XP_011538076.1  calcium-activated potassium channel subunit alpha-1 isoform X6

    UniProtKB/TrEMBL
    A0A1W2PQU4
    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  38. XM_024447986.2XP_024303754.1  calcium-activated potassium channel subunit alpha-1 isoform X29

    UniProtKB/TrEMBL
    J3KQ16
    Conserved Domains (3) summary
    pfam00520
    Location:21238
    Ion_trans; Ion transport protein
    pfam03493
    Location:387475
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    cl21454
    Location:252365
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  39. XM_047425200.1XP_047281156.1  calcium-activated potassium channel subunit alpha-1 isoform X30

    UniProtKB/TrEMBL
    J3KQ16
    Related
    ENSP00000346321.6, ENST00000354353.9
  40. XM_017016219.3XP_016871708.1  calcium-activated potassium channel subunit alpha-1 isoform X31

  41. XM_047425201.1XP_047281157.1  calcium-activated potassium channel subunit alpha-1 isoform X33

    UniProtKB/TrEMBL
    A0A1W2PQ39
    Related
    ENSP00000492236.1, ENST00000639120.1
  42. XM_011539784.3XP_011538086.1  calcium-activated potassium channel subunit alpha-1 isoform X32

    Conserved Domains (4) summary
    pfam00520
    Location:254440
    Ion_trans; Ion transport protein
    pfam03493
    Location:589677
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:350435
    Ion_trans_2; Ion channel
    cl21454
    Location:454567
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_007061964.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    77738326..78506527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365843.1XP_054221818.1  calcium-activated potassium channel subunit alpha-1 isoform X41

    UniProtKB/TrEMBL
    A0A1W2PNQ3, H0Y382
  2. XM_054365842.1XP_054221817.1  calcium-activated potassium channel subunit alpha-1 isoform X40

    UniProtKB/TrEMBL
    A0A1W2PNW6, A0A1W2PNY9
  3. XM_054365841.1XP_054221816.1  calcium-activated potassium channel subunit alpha-1 isoform X39

    UniProtKB/TrEMBL
    A0A1W2PNY9, A0A1W2PQA0
  4. XM_054365838.1XP_054221813.1  calcium-activated potassium channel subunit alpha-1 isoform X36

    UniProtKB/TrEMBL
    A0A0A0MRR0, A0A1W2PPY5
  5. XM_054365836.1XP_054221811.1  calcium-activated potassium channel subunit alpha-1 isoform X34

    UniProtKB/TrEMBL
    A0A0A0MRR0
  6. XM_054365828.1XP_054221803.1  calcium-activated potassium channel subunit alpha-1 isoform X26

    UniProtKB/TrEMBL
    A0A1W2PPX7
  7. XM_054365827.1XP_054221802.1  calcium-activated potassium channel subunit alpha-1 isoform X25

    UniProtKB/TrEMBL
    A0A1W2PNH9
  8. XM_054365820.1XP_054221795.1  calcium-activated potassium channel subunit alpha-1 isoform X18

    UniProtKB/TrEMBL
    A0A1W2PPX7, Q5SVJ9
  9. XM_054365819.1XP_054221794.1  calcium-activated potassium channel subunit alpha-1 isoform X17

    UniProtKB/TrEMBL
    A0A1W2PNH9, A0A1W2PR62
  10. XM_054365837.1XP_054221812.1  calcium-activated potassium channel subunit alpha-1 isoform X35

    UniProtKB/TrEMBL
    A0A1W2PRV4, Q5SVJ8
  11. XM_054365839.1XP_054221814.1  calcium-activated potassium channel subunit alpha-1 isoform X37

    UniProtKB/TrEMBL
    H0Y382
  12. XM_054365830.1XP_054221805.1  calcium-activated potassium channel subunit alpha-1 isoform X28

    UniProtKB/TrEMBL
    A0A1W2PQ61, H0Y382
  13. XM_054365840.1XP_054221815.1  calcium-activated potassium channel subunit alpha-1 isoform X38

    UniProtKB/TrEMBL
    A0A1W2PPZ1, A0A1W2PRB0
  14. XM_054365826.1XP_054221801.1  calcium-activated potassium channel subunit alpha-1 isoform X24

    UniProtKB/TrEMBL
    A0A1W2PRG5, Q5SVJ7
  15. XM_054365818.1XP_054221793.1  calcium-activated potassium channel subunit alpha-1 isoform X16

    UniProtKB/TrEMBL
    A0A1W2PPX7, A0A1W2PRN5
  16. XM_054365817.1XP_054221792.1  calcium-activated potassium channel subunit alpha-1 isoform X15

    UniProtKB/TrEMBL
    A0A1W2PNH9
  17. XM_054365824.1XP_054221799.1  calcium-activated potassium channel subunit alpha-1 isoform X22

    UniProtKB/TrEMBL
    A0A1W2PQ93
  18. XM_054365815.1XP_054221790.1  calcium-activated potassium channel subunit alpha-1 isoform X13

    UniProtKB/TrEMBL
    A0A1W2PQ93
  19. XM_054365814.1XP_054221789.1  calcium-activated potassium channel subunit alpha-1 isoform X12

    UniProtKB/TrEMBL
    A0A1W2PNH9
  20. XM_054365809.1XP_054221784.1  calcium-activated potassium channel subunit alpha-1 isoform X7

    UniProtKB/TrEMBL
    A0A1W2PNH9
  21. XM_054365822.1XP_054221797.1  calcium-activated potassium channel subunit alpha-1 isoform X20

    UniProtKB/TrEMBL
    A0A1W2PNH9
  22. XM_054365812.1XP_054221787.1  calcium-activated potassium channel subunit alpha-1 isoform X10

    UniProtKB/TrEMBL
    A0A1W2PQ93
  23. XM_054365807.1XP_054221782.1  calcium-activated potassium channel subunit alpha-1 isoform X5

    UniProtKB/TrEMBL
    A0A1W2PPX7
  24. XM_054365806.1XP_054221781.1  calcium-activated potassium channel subunit alpha-1 isoform X4

    UniProtKB/TrEMBL
    A0A1W2PNH9
  25. XM_054365804.1XP_054221779.1  calcium-activated potassium channel subunit alpha-1 isoform X2

    UniProtKB/TrEMBL
    A0A1W2PPX7
  26. XM_054365803.1XP_054221778.1  calcium-activated potassium channel subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0A1W2PRG5
  27. XM_054365844.1XP_054221819.1  calcium-activated potassium channel subunit alpha-1 isoform X42

    UniProtKB/TrEMBL
    A0A0A0MRC3
  28. XM_054365829.1XP_054221804.1  calcium-activated potassium channel subunit alpha-1 isoform X27

    UniProtKB/TrEMBL
    A0A1W2PQU4
  29. XM_054365821.1XP_054221796.1  calcium-activated potassium channel subunit alpha-1 isoform X19

    UniProtKB/TrEMBL
    A0A1W2PQU4
  30. XM_054365811.1XP_054221786.1  calcium-activated potassium channel subunit alpha-1 isoform X9

    UniProtKB/TrEMBL
    A0A1W2PQU4
  31. XM_054365825.1XP_054221800.1  calcium-activated potassium channel subunit alpha-1 isoform X23

    UniProtKB/TrEMBL
    A0A1W2PQU4
  32. XM_054365810.1XP_054221785.1  calcium-activated potassium channel subunit alpha-1 isoform X8

    UniProtKB/TrEMBL
    A0A1W2PQU4
  33. XM_054365823.1XP_054221798.1  calcium-activated potassium channel subunit alpha-1 isoform X21

    UniProtKB/TrEMBL
    A0A1W2PQU4
  34. XM_054365816.1XP_054221791.1  calcium-activated potassium channel subunit alpha-1 isoform X14

    UniProtKB/TrEMBL
    A0A1W2PQU4
  35. XM_054365805.1XP_054221780.1  calcium-activated potassium channel subunit alpha-1 isoform X3

    UniProtKB/TrEMBL
    A0A1W2PQU4
  36. XM_054365813.1XP_054221788.1  calcium-activated potassium channel subunit alpha-1 isoform X11

    UniProtKB/TrEMBL
    A0A1W2PQU4
  37. XM_054365808.1XP_054221783.1  calcium-activated potassium channel subunit alpha-1 isoform X6

    UniProtKB/TrEMBL
    A0A1W2PQU4
  38. XM_054365832.1XP_054221807.1  calcium-activated potassium channel subunit alpha-1 isoform X29

    UniProtKB/TrEMBL
    J3KQ16
  39. XM_054365831.1XP_054221806.1  calcium-activated potassium channel subunit alpha-1 isoform X30

    UniProtKB/TrEMBL
    J3KQ16
  40. XM_054365833.1XP_054221808.1  calcium-activated potassium channel subunit alpha-1 isoform X31

  41. XM_054365835.1XP_054221810.1  calcium-activated potassium channel subunit alpha-1 isoform X33

    UniProtKB/TrEMBL
    A0A1W2PQ39
  42. XM_054365834.1XP_054221809.1  calcium-activated potassium channel subunit alpha-1 isoform X32

RNA

  1. XR_008488214.1 RNA Sequence