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CA13 carbonic anhydrase 13 [ Homo sapiens (human) ]

Gene ID: 377677, updated on 13-May-2022

Summary

Official Symbol
CA13provided by HGNC
Official Full Name
carbonic anhydrase 13provided by HGNC
Primary source
HGNC:HGNC:14914
See related
Ensembl:ENSG00000185015 MIM:611436; AllianceGenome:HGNC:14914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAXIII
Summary
Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800.[supplied by OMIM, Mar 2008]
Expression
Broad expression in small intestine (RPKM 7.8), duodenum (RPKM 6.3) and 18 other tissues See more
Orthologs
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Genomic context

See CA13 in Genome Data Viewer
Location:
8q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (85245458..85284073)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (85684055..85722800)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (86157687..86196302)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 5 Neighboring gene uncharacterized LOC124901969 Neighboring gene uncharacterized LOC105375936 Neighboring gene ribosomal biogenesis factor Neighboring gene carbonic anhydrase 1 Neighboring gene uncharacterized LOC124901970 Neighboring gene CA1 upstream erythroid promoter

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CA3

Homology

Clone Names

  • FLJ36434, FLJ37995, MGC59868

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydro-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in myelin sheath IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carbonic anhydrase 13
Names
CA-XIII
carbonate dehydratase XIII
carbonic anhydrase XIII
NP_940986.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198584.3NP_940986.1  carbonic anhydrase 13

    See identical proteins and their annotated locations for NP_940986.1

    Status: VALIDATED

    Source sequence(s)
    AC011773, AK095314, BC052602, DB287770
    Consensus CDS
    CCDS6236.1
    UniProtKB/Swiss-Prot
    Q8N1Q1
    Related
    ENSP00000318912.3, ENST00000321764.4
    Conserved Domains (1) summary
    cd03119
    Location:2261
    alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    85245458..85284073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    85684055..85722800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)