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CA13 carbonic anhydrase 13 [ Homo sapiens (human) ]

Gene ID: 377677, updated on 1-Jun-2020

Summary

Official Symbol
CA13provided by HGNC
Official Full Name
carbonic anhydrase 13provided by HGNC
Primary source
HGNC:HGNC:14914
See related
Ensembl:ENSG00000185015 MIM:611436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAXIII
Summary
Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800.[supplied by OMIM, Mar 2008]
Expression
Broad expression in small intestine (RPKM 7.8), duodenum (RPKM 6.3) and 18 other tissues See more
Orthologs

Genomic context

See CA13 in Genome Data Viewer
Location:
8q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (85245458..85284073)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (86157716..86196302)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 5 Neighboring gene uncharacterized LOC105375936 Neighboring gene uncharacterized LOC105375935 Neighboring gene ribosomal biogenesis factor Neighboring gene carbonic anhydrase 1 Neighboring gene CA1 upstream erythroid promoter Neighboring gene CA3 antisense RNA 1 Neighboring gene carbonic anhydrase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog

Pathways from PubChem

General gene information

Markers

Potential readthrough

Included gene: CA3

Homology

Clone Names

  • FLJ36434, FLJ37995, MGC59868

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
hydro-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bicarbonate transport TAS
Traceable Author Statement
more info
 
one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carbonic anhydrase 13
Names
CA-XIII
carbonate dehydratase XIII
carbonic anhydrase XIII
NP_940986.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198584.3NP_940986.1  carbonic anhydrase 13

    See identical proteins and their annotated locations for NP_940986.1

    Status: VALIDATED

    Source sequence(s)
    AC011773, AK095314, BC052602, DB287770
    Consensus CDS
    CCDS6236.1
    UniProtKB/Swiss-Prot
    Q8N1Q1
    Related
    ENSP00000318912.3, ENST00000321764.4
    Conserved Domains (1) summary
    cd03119
    Location:2261
    alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    85245458..85284073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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