U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KCNK2 potassium two pore domain channel subfamily K member 2 [ Homo sapiens (human) ]

Gene ID: 3776, updated on 5-Aug-2022

Summary

Official Symbol
KCNK2provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 2provided by HGNC
Primary source
HGNC:HGNC:6277
See related
Ensembl:ENSG00000082482 MIM:603219; AllianceGenome:HGNC:6277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e
Summary
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 18.5), thyroid (RPKM 2.6) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KCNK2 in Genome Data Viewer
Location:
1q41
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (215005542..215237090)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (214245543..214477417)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (215178885..215410433)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 24 Neighboring gene uncharacterized LOC124904510 Neighboring gene uncharacterized LOC124904511 Neighboring gene voltage dependent anion channel 1 pseudogene 10 Neighboring gene uncharacterized LOC124904598

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126742, MGC126744

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables outward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium ion leak channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac ventricle development IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in cochlea development IEA
Inferred from Electronic Annotation
more info
 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to axon injury IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in astrocyte projection IEA
Inferred from Electronic Annotation
more info
 
located_in calyx of Held IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 2
Names
K2P2.1 potassium channel
TREK-1 K(+) channel subunit
TWIK-related potassium channel 1
outward rectifying potassium channel protein TREK-1
potassium channel, two pore domain subfamily K, member 2
potassium inwardly-rectifying channel, subfamily K, member 2
tandem-pore-domain potassium channel TREK-1
two pore domain potassium channel TREK-1
two pore potassium channel TPKC1
two-pore potassium channel 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017424.3NP_001017424.1  potassium channel subfamily K member 2 isoform a

    See identical proteins and their annotated locations for NP_001017424.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC092804, AK123409, AL583830, AU280191, BC069462, CD625291, CD625297, DA475072
    Consensus CDS
    CCDS41466.1
    UniProtKB/Swiss-Prot
    O95069
    UniProtKB/TrEMBL
    Q6ZW95, U3N834
    Related
    ENSP00000375765.2, ENST00000391895.6
    Conserved Domains (1) summary
    pfam07885
    Location:137192
    Ion_trans_2; Ion channel
  2. NM_001017425.3NP_001017425.2  potassium channel subfamily K member 2 isoform c

    See identical proteins and their annotated locations for NP_001017425.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and beginning of the coding region compared to variant 1. The resulting isoform (c) is slightly shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC092804, AC099675, AK123409, BC069462, DR001358, EF165334
    Consensus CDS
    CCDS41467.1
    UniProtKB/Swiss-Prot
    O95069, Q9UNE3
    UniProtKB/TrEMBL
    Q6ZW95
    Related
    ENSP00000394033.2, ENST00000444842.7
    Conserved Domains (1) summary
    pfam07885
    Location:142196
    Ion_trans_2; Ion channel
  3. NM_014217.4NP_055032.1  potassium channel subfamily K member 2 isoform b

    See identical proteins and their annotated locations for NP_055032.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and beginning of the open reading frame compared to variant 1. The resulting isoform (b) is slightly shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC092804, AC099675, AK123409, BC069462, BC101693, DR001358
    Consensus CDS
    CCDS31024.1
    UniProtKB/Swiss-Prot
    O95069
    UniProtKB/TrEMBL
    Q6ZW95, U3N6F0
    Related
    ENSP00000375764.2, ENST00000391894.6
    Conserved Domains (1) summary
    pfam07885
    Location:127181
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    215005542..215237090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001249.2XP_016856738.1  potassium channel subfamily K member 2 isoform X1

    Conserved Domains (1) summary
    pfam07885
    Location:127182
    Ion_trans_2; Ion channel
  2. XM_011509524.3XP_011507826.1  potassium channel subfamily K member 2 isoform X2

    See identical proteins and their annotated locations for XP_011507826.1

    Conserved Domains (1) summary
    pfam07885
    Location:86140
    Ion_trans_2; Ion channel
  3. XM_011509522.3XP_011507824.1  potassium channel subfamily K member 2 isoform X2

    See identical proteins and their annotated locations for XP_011507824.1

    Conserved Domains (1) summary
    pfam07885
    Location:86140
    Ion_trans_2; Ion channel
  4. XM_047419881.1XP_047275837.1  potassium channel subfamily K member 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    214245543..214477417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)