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KCNK2 potassium two pore domain channel subfamily K member 2 [ Homo sapiens (human) ]

Gene ID: 3776, updated on 13-Feb-2019

Summary

Official Symbol
KCNK2provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 2provided by HGNC
Primary source
HGNC:HGNC:6277
See related
Ensembl:ENSG00000082482 MIM:603219
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e
Summary
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in adrenal (RPKM 18.5), thyroid (RPKM 2.6) and 1 other tissue See more
Orthologs

Genomic context

See KCNK2 in Genome Data Viewer
Location:
1q41
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (215002920..215237093)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (215178885..215410436)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372915 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 24 Neighboring gene voltage dependent anion channel 1 pseudogene 10 Neighboring gene uncharacterized LOC105372919

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Phase 4 - resting membrane potential, organism-specific biosystem (from REACTOME)
    Phase 4 - resting membrane potential, organism-specific biosystemPhase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • TWIK related potassium channel (TREK), organism-specific biosystem (from REACTOME)
    TWIK related potassium channel (TREK), organism-specific biosystemTREK1 and TREK 2 are activated by physiochemical changes like stretch, convex deformation of the plasma membrane, depolarization, heat and intracellular acidosis. Polyunsaturated fatty acids (PUFA) i...
  • Tandem pore domain potassium channels, organism-specific biosystem (from REACTOME)
    Tandem pore domain potassium channels, organism-specific biosystemTandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mech...

General gene information

Markers

Homology

Clone Names

  • MGC126742, MGC126744

Gene Ontology Provided by GOA

Function Evidence Code Pubs
outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
outward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion leak channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cardiac ventricle development IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cochlea development IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
response to axon injury IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
astrocyte projection IEA
Inferred from Electronic Annotation
more info
 
calyx of Held IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 2
Names
K2P2.1 potassium channel
TREK-1 K(+) channel subunit
TWIK-related potassium channel 1
outward rectifying potassium channel protein TREK-1
potassium channel subfamily k member 2 variant 1
potassium channel subfamily k member 2 variant 2
potassium channel, two pore domain subfamily K, member 2
potassium inwardly-rectifying channel, subfamily K, member 2
tandem-pore-domain potassium channel TREK-1
two pore domain potassium channel TREK-1
two pore potassium channel TPKC1
two-pore potassium channel 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017424.2NP_001017424.1  potassium channel subfamily K member 2 isoform a

    See identical proteins and their annotated locations for NP_001017424.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC092804, AK123409, AL583830, AU280191, BC069462, CD625291, CD625297, DA475072
    Consensus CDS
    CCDS41466.1
    UniProtKB/Swiss-Prot
    O95069
    UniProtKB/TrEMBL
    Q6ZW95, U3N834
    Related
    ENSP00000375765.2, ENST00000391895.6
    Conserved Domains (1) summary
    pfam07885
    Location:137192
    Ion_trans_2; Ion channel
  2. NM_001017425.2NP_001017425.2  potassium channel subfamily K member 2 isoform c

    See identical proteins and their annotated locations for NP_001017425.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and beginning of the coding region compared to variant 1. The resulting isoform (c) is slightly shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC092804, AK123409, BC069462, DR001358, EF165334
    Consensus CDS
    CCDS41467.1
    UniProtKB/Swiss-Prot
    O95069
    UniProtKB/TrEMBL
    Q6ZW95
    Related
    ENSP00000394033.2, ENST00000444842.6
    Conserved Domains (1) summary
    pfam07885
    Location:141196
    Ion_trans_2; Ion channel
  3. NM_014217.3NP_055032.1  potassium channel subfamily K member 2 isoform b

    See identical proteins and their annotated locations for NP_055032.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and beginning of the open reading frame compared to variant 1. The resulting isoform (b) is slightly shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC092804, AK123409, BC069462, BC101693, DR001358
    Consensus CDS
    CCDS31024.1
    UniProtKB/Swiss-Prot
    O95069
    UniProtKB/TrEMBL
    Q6ZW95, U3N6F0
    Related
    ENSP00000375764.2, ENST00000391894.6
    Conserved Domains (1) summary
    pfam07885
    Location:126181
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    215002920..215237093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001248.1XP_016856737.1  potassium channel subfamily K member 2 isoform X1

    UniProtKB/Swiss-Prot
    O95069
    UniProtKB/TrEMBL
    U3N834
    Conserved Domains (1) summary
    pfam07885
    Location:137192
    Ion_trans_2; Ion channel
  2. XM_017001249.1XP_016856738.1  potassium channel subfamily K member 2 isoform X2

    Conserved Domains (1) summary
    pfam07885
    Location:127182
    Ion_trans_2; Ion channel
  3. XM_011509522.2XP_011507824.1  potassium channel subfamily K member 2 isoform X3

    See identical proteins and their annotated locations for XP_011507824.1

    Conserved Domains (1) summary
    pfam07885
    Location:85140
    Ion_trans_2; Ion channel
  4. XM_011509524.2XP_011507826.1  potassium channel subfamily K member 2 isoform X3

    See identical proteins and their annotated locations for XP_011507826.1

    Conserved Domains (1) summary
    pfam07885
    Location:85140
    Ion_trans_2; Ion channel
  5. XM_011509523.1XP_011507825.1  potassium channel subfamily K member 2 isoform X3

    See identical proteins and their annotated locations for XP_011507825.1

    Conserved Domains (1) summary
    pfam07885
    Location:85140
    Ion_trans_2; Ion channel
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