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KCNK1 potassium two pore domain channel subfamily K member 1 [ Homo sapiens (human) ]

Gene ID: 3775, updated on 6-May-2021

Summary

Official Symbol
KCNK1provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 1provided by HGNC
Primary source
HGNC:HGNC:6272
See related
Ensembl:ENSG00000135750 MIM:601745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1
Summary
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 19.7), stomach (RPKM 14.9) and 18 other tissues See more
Orthologs
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Genomic context

See KCNK1 in Genome Data Viewer
Location:
1q42.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (233614106..233672514)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (233749852..233808260)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 21 Neighboring gene RNA, U4 small nuclear 77, pseudogene Neighboring gene microRNA 4427 Neighboring gene uncharacterized LOC107985362 Neighboring gene uncharacterized LOC107985363 Neighboring gene solute carrier family 35 member F3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of periodontal pathogen colonization.
GeneReviews: Not available
Genome-wide meta-analysis for severe diabetic retinopathy.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables inward rectifier potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
enables potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium ion leak channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in brush border membrane IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
part_of inward rectifier potassium channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
potassium channel subfamily K member 1
Names
inward rectifying potassium channel protein TWIK-1
potassium channel K2P1
potassium channel KCNO1
potassium channel, two pore domain subfamily K, member 1
potassium inwardly-rectifying channel, subfamily K, member 1
tandem of P domains in a weak inward rectifying K+ channel 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002245.4NP_002236.1  potassium channel subfamily K member 1

    See identical proteins and their annotated locations for NP_002236.1

    Status: REVIEWED

    Source sequence(s)
    AL356357, BC018051, BQ022191, U90065
    Consensus CDS
    CCDS1599.1
    UniProtKB/Swiss-Prot
    O00180
    UniProtKB/TrEMBL
    A0A024R3T2
    Related
    ENSP00000355580.3, ENST00000366621.8
    Conserved Domains (1) summary
    pfam07885
    Location:101157
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    233614106..233672514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544184.2XP_011542486.1  potassium channel subfamily K member 1 isoform X1

    Related
    ENST00000366620.5
    Conserved Domains (1) summary
    pfam07885
    Location:123199
    Ion_trans_2; Ion channel
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