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KCNK1 potassium two pore domain channel subfamily K member 1 [ Homo sapiens (human) ]

Gene ID: 3775, updated on 12-Oct-2019

Summary

Official Symbol
KCNK1provided by HGNC
Official Full Name
potassium two pore domain channel subfamily K member 1provided by HGNC
Primary source
HGNC:HGNC:6272
See related
Ensembl:ENSG00000135750 MIM:601745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1
Summary
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 19.7), stomach (RPKM 14.9) and 18 other tissues See more
Orthologs

Genomic context

See KCNK1 in Genome Data Viewer
Location:
1q42.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (233614106..233672514)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (233749750..233808258)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 21 Neighboring gene RNA, U4 small nuclear 77, pseudogene Neighboring gene microRNA 4427 Neighboring gene uncharacterized LOC107985362 Neighboring gene uncharacterized LOC107985363 Neighboring gene solute carrier family 35 member F3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of periodontal pathogen colonization.
NHGRI GWA Catalog
Genome-wide meta-analysis for severe diabetic retinopathy.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Phase 4 - resting membrane potential, organism-specific biosystem (from REACTOME)
    Phase 4 - resting membrane potential, organism-specific biosystemPhase 4 describes the membrane potential when a cell is not being stimulated. The normal resting potential in the ventricular myocardium is between -85 to -95 mV. The membrane is most permeable to K+...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK), organism-specific biosystem (from REACTOME)
    Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK), organism-specific biosystemTWIK channels exhibit very low current and comprise of TWIK1, TWIK2 and KCNK7 members. TWIK current may be low due to rapid recycling of the channels from the plasma membrane.
  • Tandem pore domain potassium channels, organism-specific biosystem (from REACTOME)
    Tandem pore domain potassium channels, organism-specific biosystemTandem pore domain K+ channels (K2p) produce leak K+ current which stabilizes negative membrane potential and counter balances depolarization. These channels are regulated by voltage independent mech...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
inward rectifier potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion leak channel activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cardiac conduction TAS
Traceable Author Statement
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of resting membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to nicotine IEA
Inferred from Electronic Annotation
more info
 
sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
stabilization of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
brush border membrane IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
inward rectifier potassium channel complex IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
potassium channel subfamily K member 1
Names
inward rectifying potassium channel protein TWIK-1
potassium channel K2P1
potassium channel KCNO1
potassium channel, two pore domain subfamily K, member 1
potassium inwardly-rectifying channel, subfamily K, member 1
tandem of P domains in a weak inward rectifying K+ channel 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002245.4NP_002236.1  potassium channel subfamily K member 1

    See identical proteins and their annotated locations for NP_002236.1

    Status: REVIEWED

    Source sequence(s)
    AL356357, BC018051, BQ022191, U90065
    Consensus CDS
    CCDS1599.1
    UniProtKB/Swiss-Prot
    O00180
    UniProtKB/TrEMBL
    A0A024R3T2
    Related
    ENSP00000355580.3, ENST00000366621.8
    Conserved Domains (1) summary
    pfam07885
    Location:101157
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    233614106..233672514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544184.2XP_011542486.1  potassium channel subfamily K member 1 isoform X1

    Conserved Domains (1) summary
    pfam07885
    Location:123199
    Ion_trans_2; Ion channel
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