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KCNJ15 potassium inwardly rectifying channel subfamily J member 15 [ Homo sapiens (human) ]

Gene ID: 3772, updated on 1-Jun-2020

Summary

Official Symbol
KCNJ15provided by HGNC
Official Full Name
potassium inwardly rectifying channel subfamily J member 15provided by HGNC
Primary source
HGNC:HGNC:6261
See related
Ensembl:ENSG00000157551 MIM:602106
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRKK; KIR1.3; KIR4.2
Summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]
Expression
Biased expression in kidney (RPKM 38.5), thyroid (RPKM 23.6) and 6 other tissues See more
Orthologs

Genomic context

See KCNJ15 in Genome Data Viewer
Location:
21q22.13-q22.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (38229926..38307357)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (39601837..39675043)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5297 Neighboring gene Sharpr-MPRA regulatory region 13169 Neighboring gene spermatogenesis associated 20 pseudogene 1 Neighboring gene uncharacterized LOC105372801 Neighboring gene long intergenic non-protein coding RNA 1423 Neighboring gene uncharacterized LOC107985513

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13584

Gene Ontology Provided by GOA

Function Evidence Code Pubs
inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
regulation of ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ATP-sensitive inward rectifier potassium channel 15
Names
inward rectifier K(+) channel Kir1.3
inward rectifier K(+) channel Kir4.2
inward rectifier K+ channel KIR4.2
potassium channel, inwardly rectifying subfamily J member 15
potassium voltage-gated channel subfamily J member 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276435.1NP_001263364.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263364.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction and contains two additional exons in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, BC013327, DA968871
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Related
    ENSP00000484960.1, ENST00000612702.4
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  2. NM_001276436.1NP_001263365.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction and contains two additional exons in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, BC013327, DA968871, DB232867
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Related
    ENSP00000479100.1, ENST00000613499.4
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  3. NM_001276437.2NP_001263366.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction and contains an additional exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, DA670230, DA675388
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  4. NM_001276438.2NP_001263367.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate 5'-most exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, DA673158, DA675388
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  5. NM_001276439.2NP_001263368.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_001263368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice junction and contains an additional exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, DA673158
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  6. NM_002243.5NP_002234.2  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_002234.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction and contains an additional exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, DA968871
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Related
    ENSP00000331698.3, ENST00000328656.8
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  7. NM_170736.3NP_733932.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_733932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, AP001422, BC013327, D87291
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Related
    ENSP00000381911.2, ENST00000398938.7
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  8. NM_170737.2NP_733933.1  ATP-sensitive inward rectifier potassium channel 15

    See identical proteins and their annotated locations for NP_733933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5'-most exon in the 5' UTR compared to variant 1. All eight variants encode the same protein.
    Source sequence(s)
    AI344546, AI453386, BC013327, DA632853
    Consensus CDS
    CCDS13656.1
    UniProtKB/Swiss-Prot
    Q99712
    Related
    ENSP00000381907.1, ENST00000398934.5
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    38229926..38307357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529560.2XP_011527862.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_011527862.1

    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  2. XM_017028343.1XP_016883832.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  3. XM_011529561.2XP_011527863.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_011527863.1

    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  4. XM_006724002.2XP_006724065.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_006724065.1

    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  5. XM_017028344.1XP_016883833.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  6. XM_017028345.1XP_016883834.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
  7. XM_005260975.2XP_005261032.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

    See identical proteins and their annotated locations for XP_005261032.1

    UniProtKB/Swiss-Prot
    Q99712
    Conserved Domains (1) summary
    pfam01007
    Location:30356
    IRK; Inward rectifier potassium channel
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