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KCNJ10 potassium inwardly rectifying channel subfamily J member 10 [ Homo sapiens (human) ]

Gene ID: 3766, updated on 11-Jun-2021

Summary

Official Symbol
KCNJ10provided by HGNC
Official Full Name
potassium inwardly rectifying channel subfamily J member 10provided by HGNC
Primary source
HGNC:HGNC:6256
See related
Ensembl:ENSG00000177807 MIM:602208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIR1.2; KIR4.1; SESAME; BIRK-10; KCNJ13-PEN
Summary
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 52.7), kidney (RPKM 14.4) and 2 other tissues See more
Orthologs
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Genomic context

See KCNJ10 in Genome Data Viewer
Location:
1q23.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (160037467..160070160, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (160007257..160039950, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27a pseudogene 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class M Neighboring gene Sharpr-MPRA regulatory region 2622 Neighboring gene potassium inwardly rectifying channel subfamily J member 9 Neighboring gene immunoglobulin superfamily member 8

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-activated inward rectifier potassium channel activity TAS
Traceable Author Statement
more info
PubMed 
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adult walking behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system myelination IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamate reuptake IEA
Inferred from Electronic Annotation
more info
 
involved_in non-motile cilium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of potassium ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in potassium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of long-term neuronal synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of resting membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in astrocyte projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ciliary base IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ATP-sensitive inward rectifier potassium channel 10
Names
ATP-dependent inwardly rectifying potassium channel Kir4.1
glial ATP-dependent inwardly rectifying potassium channel KIR4.1
inward rectifier K(+) channel Kir1.2
inward rectifier K+ channel KIR1.2
potassium channel, inwardly rectifying subfamily J member 10
potassium voltage-gated channel subfamily J member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016411.1 RefSeqGene

    Range
    5012..37705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002241.5NP_002232.2  ATP-sensitive inward rectifier potassium channel 10

    See identical proteins and their annotated locations for NP_002232.2

    Status: REVIEWED

    Source sequence(s)
    AL513302, BC131627, BM675618, DA958759
    Consensus CDS
    CCDS1193.1
    UniProtKB/Swiss-Prot
    P78508
    Related
    ENSP00000495557.1, ENST00000644903.1
    Conserved Domains (2) summary
    pfam01007
    Location:31172
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:179354
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    160037467..160070160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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