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KCNJ9 potassium inwardly rectifying channel subfamily J member 9 [ Homo sapiens (human) ]

Gene ID: 3765, updated on 7-Jun-2020

Summary

Official Symbol
KCNJ9provided by HGNC
Official Full Name
potassium inwardly rectifying channel subfamily J member 9provided by HGNC
Primary source
HGNC:HGNC:6270
See related
Ensembl:ENSG00000162728 MIM:600932
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIRK3; KIR3.3
Summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 8.9) See more
Orthologs

Genomic context

See KCNJ9 in Genome Data Viewer
Location:
1q23.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (160081538..160090563)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (160051360..160059212)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class M Neighboring gene potassium inwardly rectifying channel subfamily J member 10 Neighboring gene immunoglobulin superfamily member 8 Neighboring gene Sharpr-MPRA regulatory region 5459

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein activated inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
parallel fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G protein-activated inward rectifier potassium channel 3
Names
G protein-coupled inward rectifier potassium channel
inward rectifier K(+) channel Kir3.3
inwardly rectifier K+ channel KIR3.3
potassium channel, inwardly rectifying subfamily J member 9
potassium voltage-gated channel subfamily J member 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004983.3NP_004974.2  G protein-activated inward rectifier potassium channel 3

    See identical proteins and their annotated locations for NP_004974.2

    Status: REVIEWED

    Source sequence(s)
    AL121987
    Consensus CDS
    CCDS1194.1
    UniProtKB/Swiss-Prot
    Q92806
    Related
    ENSP00000357067.3, ENST00000368088.4
    Conserved Domains (1) summary
    pfam01007
    Location:25334
    IRK; Inward rectifier potassium channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    160081538..160090563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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