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RAB15 RAB15, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 376267, updated on 5-Jan-2022

Summary

Official Symbol
RAB15provided by HGNC
Official Full Name
RAB15, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:20150
See related
Ensembl:ENSG00000139998 MIM:619547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTP binding activity and GTPase activity. Involved in positive regulation of regulated secretory pathway. Located in cilium; endosome membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in brain (RPKM 21.8), urinary bladder (RPKM 12.3) and 21 other tissues See more
Orthologs
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Genomic context

See RAB15 in Genome Data Viewer
Location:
14q23.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (64945816..64972336, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65412534..65439054, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene CHURC1-FNTB readthrough Neighboring gene churchill domain containing 1 Neighboring gene glutathione peroxidase 2 Neighboring gene uncharacterized LOC107984655 Neighboring gene farnesyltransferase, CAAX box, beta Neighboring gene MYC associated factor X Neighboring gene microRNA 4706

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Rab protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of regulated secretory pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of regulated secretory pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in insulin-responsive compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-15
Names
RAB15, member RAS onocogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308154.2NP_001295083.1  ras-related protein Rab-15 isoform 2

    See identical proteins and their annotated locations for NP_001295083.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift and novel 3' coding region compared to variant 1. It encodes isoform 2, which is longer than and has a novel C-terminus compared to isoform 1.
    Source sequence(s)
    AB678452, AB678453, AI096837, AL139022, BX248046
    Consensus CDS
    CCDS76691.1
    UniProtKB/Swiss-Prot
    P59190
    UniProtKB/TrEMBL
    G5EMR8
    Related
    ENSP00000434103.3, ENST00000533601.7
    Conserved Domains (1) summary
    cd04117
    Location:9172
    Rab15; Rab GTPase family 15 (Rab15)
  2. NM_001330182.2NP_001317111.1  ras-related protein Rab-15 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon, and uses an alternate splice site, compared to isoform 1. These differences result in the use of a downtream start codon, and a frameshift and novel 3' coding region compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, and a novel C-terminus, compared to isoform 1.
    Source sequence(s)
    AL139022, W81100
    Consensus CDS
    CCDS81812.1
    UniProtKB/TrEMBL
    G3V196
    Related
    ENSP00000452195.2, ENST00000554593.2
    Conserved Domains (1) summary
    cl21455
    Location:1126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_198686.3NP_941959.1  ras-related protein Rab-15 isoform 1

    See identical proteins and their annotated locations for NP_941959.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL139022, BC040679, BX248046, CN352234, W81100
    Consensus CDS
    CCDS9768.1
    UniProtKB/Swiss-Prot
    P59190
    Related
    ENSP00000267512.5, ENST00000267512.9
    Conserved Domains (1) summary
    cl38936
    Location:9172
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    64945816..64972336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449577.1XP_024305345.1  ras-related protein Rab-15 isoform X1

    Related
    ENSP00000496006.1, ENST00000646728.1
    Conserved Domains (1) summary
    cl21455
    Location:1126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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