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KCNJ5 potassium inwardly rectifying channel subfamily J member 5 [ Homo sapiens (human) ]

Gene ID: 3762, updated on 1-Aug-2020

Summary

Official Symbol
KCNJ5provided by HGNC
Official Full Name
potassium inwardly rectifying channel subfamily J member 5provided by HGNC
Primary source
HGNC:HGNC:6266
See related
Ensembl:ENSG00000120457 MIM:600734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIR; GIRK4; KATP1; LQT13; KIR3.4
Summary
This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017]
Expression
Biased expression in adrenal (RPKM 34.9), spleen (RPKM 8.6) and 4 other tissues See more
Orthologs

Genomic context

See KCNJ5 in Genome Data Viewer
Location:
11q24.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (128891356..128921163)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (128761313..128791060)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNA Neighboring gene Fli-1 proto-oncogene, ETS transcription factor Neighboring gene uncharacterized LOC107984409 Neighboring gene potassium inwardly rectifying channel subfamily J member 1 Neighboring gene chromosome 11 open reading frame 45 Neighboring gene tumor protein p53 regulated apoptosis inducing protein 1 Neighboring gene Rho GTPase activating protein 32 Neighboring gene RNA, U6 small nuclear 876, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of potassium inwardly-rectifying channel, subfamily J, member 5 (KCNJ5) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of potassium inwardly-rectifying channel, subfamily J, member 5 (KCNJ5) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
T-tubule IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G protein-activated inward rectifier potassium channel 4
Names
IRK-4
cardiac ATP-sensitive potassium channel
heart KATP channel
inward rectifier K+ channel KIR3.4
potassium channel, inwardly rectifying subfamily J, member 5
potassium voltage-gated channel subfamily J member 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023406.2 RefSeqGene

    Range
    5001..31652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_333

mRNA and Protein(s)

  1. NM_000890.5NP_000881.3  G protein-activated inward rectifier potassium channel 4

    See identical proteins and their annotated locations for NP_000881.3

    Status: REVIEWED

    Source sequence(s)
    AK312837, AP000920
    Consensus CDS
    CCDS8479.1
    UniProtKB/Swiss-Prot
    P48544
    Related
    ENSP00000433295.1, ENST00000529694.6
    Conserved Domains (1) summary
    pfam01007
    Location:54373
    IRK; Inward rectifier potassium channel
  2. NM_001354169.2NP_001341098.1  G protein-activated inward rectifier potassium channel 4

    Status: REVIEWED

    Source sequence(s)
    AP000920, BC069571, BX647543
    Consensus CDS
    CCDS8479.1
    Related
    ENSP00000339960.4, ENST00000338350.4
    Conserved Domains (1) summary
    pfam01007
    Location:54373
    IRK; Inward rectifier potassium channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    128891356..128921163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542810.3XP_011541112.1  G protein-activated inward rectifier potassium channel 4 isoform X1

    See identical proteins and their annotated locations for XP_011541112.1

    UniProtKB/Swiss-Prot
    P48544
    Related
    ENSP00000434266.1, ENST00000533599.1
    Conserved Domains (1) summary
    pfam01007
    Location:54373
    IRK; Inward rectifier potassium channel
  2. XM_011542809.2XP_011541111.1  G protein-activated inward rectifier potassium channel 4 isoform X1

    See identical proteins and their annotated locations for XP_011541111.1

    UniProtKB/Swiss-Prot
    P48544
    Conserved Domains (1) summary
    pfam01007
    Location:54373
    IRK; Inward rectifier potassium channel
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