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SPATC1 spermatogenesis and centriole associated 1 [ Homo sapiens (human) ]

Gene ID: 375686, updated on 25-Jan-2022

Summary

Official Symbol
SPATC1provided by HGNC
Official Full Name
spermatogenesis and centriole associated 1provided by HGNC
Primary source
HGNC:HGNC:30510
See related
Ensembl:ENSG00000186583 MIM:610874; AllianceGenome:HGNC:30510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPATA15
Summary
Predicted to enable gamma-tubulin binding activity. Located in centrosome. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis (RPKM 4.1), bone marrow (RPKM 1.1) and 1 other tissue See more
Orthologs
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Genomic context

See SPATC1 in Genome Data Viewer
Location:
8q24.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144010992..144047114)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145086448..145102015)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene poly(ADP-ribose) polymerase family member 10 Neighboring gene glutamate ionotropic receptor NMDA type subunit associated protein 1 Neighboring gene sphingomyelin phosphodiesterase 5 (pseudogene) Neighboring gene 5-oxoprolinase, ATP-hydrolysing Neighboring gene microRNA 6846

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC61633

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
speriolin
Names
spermatogenesis and centriole-associated protein 1
spermatogenesis-associated protein 15
spermatogenic cell-specific Cdc20-binding protein
testicular tissue protein Li 181

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134374.2NP_001127846.1  speriolin isoform 2

    See identical proteins and their annotated locations for NP_001127846.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region and differs in the 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC206437, AK301710, BC053547, DB052198
    Consensus CDS
    CCDS47937.1
    UniProtKB/Swiss-Prot
    Q76KD6
    UniProtKB/TrEMBL
    A0A140VJV4
    Related
    ENSP00000387613.2, ENST00000447830.2
    Conserved Domains (1) summary
    pfam15058
    Location:1228
    Speriolin_N; Speriolin N terminus
  2. NM_198572.3NP_940974.2  speriolin isoform 1

    See identical proteins and their annotated locations for NP_940974.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB092352, AC206437, BC053547, DB052198
    Consensus CDS
    CCDS6413.2
    UniProtKB/Swiss-Prot
    Q76KD6
    Related
    ENSP00000366690.3, ENST00000377470.8
    Conserved Domains (2) summary
    pfam15058
    Location:1228
    Speriolin_N; Speriolin N terminus
    pfam15059
    Location:445591
    Speriolin_C; Speriolin C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144010992..144047114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517022.2XP_011515324.1  speriolin isoform X2

    Conserved Domains (2) summary
    pfam15058
    Location:42222
    Speriolin_N; Speriolin N terminus
    pfam15059
    Location:439620
    Speriolin_C; Speriolin C-terminus
  2. XM_011517021.1XP_011515323.1  speriolin isoform X1

    Conserved Domains (2) summary
    pfam15058
    Location:1228
    Speriolin_N; Speriolin N terminus
    pfam15059
    Location:445626
    Speriolin_C; Speriolin C-terminus
  3. XM_017013399.1XP_016868888.1  speriolin isoform X4

    Conserved Domains (2) summary
    pfam15058
    Location:1137
    Speriolin_N; Speriolin N terminus
    pfam15059
    Location:354535
    Speriolin_C; Speriolin C-terminus
  4. XM_011517025.2XP_011515327.1  speriolin isoform X4

    See identical proteins and their annotated locations for XP_011515327.1

    Conserved Domains (2) summary
    pfam15058
    Location:1137
    Speriolin_N; Speriolin N terminus
    pfam15059
    Location:354535
    Speriolin_C; Speriolin C-terminus
  5. XM_011517023.2XP_011515325.1  speriolin isoform X3

    Conserved Domains (2) summary
    pfam15058
    Location:8166
    Speriolin_N; Speriolin N terminus
    pfam15059
    Location:383564
    Speriolin_C; Speriolin C-terminus
  6. XM_011517024.3XP_011515326.1  speriolin isoform X4

    See identical proteins and their annotated locations for XP_011515326.1

    Conserved Domains (2) summary
    pfam15058
    Location:1137
    Speriolin_N; Speriolin N terminus
    pfam15059
    Location:354535
    Speriolin_C; Speriolin C-terminus

RNA

  1. XR_928329.1 RNA Sequence

  2. XR_928328.1 RNA Sequence

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