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qkr58E-2 quaking related 58E-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37562, updated on 6-Jul-2026
Official Symbol
qkr58E-2provided by FlyBase
Official Full Name
quaking related 58E-2provided by FlyBase
Primary source
FLYBASE:FBgn0022985
Locus tag
Dmel_CG5821
See related
AllianceGenome:FB:FBgn0022985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5821; Dmel\CG5821; qkr58e-2; qrk58E-2
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in adult head; germline cell; and organism. Orthologous to human KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2) and KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See qkr58E-2 in Genome Data Viewer
Location:
58D8-58E1; 2-99 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22415560..22419001)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18303065..18306506)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene quaking related 58E-3 Neighboring gene Ventrally-expressed protein D Neighboring gene quaking related 58E-1 Neighboring gene DNA polymerase epsilon subunit 4 Neighboring gene antisense RNA:CR45152 Neighboring gene mitochondrial ribosomal protein S29 Neighboring gene rad50 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Comparative phosphoproteomics reveal new candidates in the regulation of spermatogenesis of Drosophila melanogaster. Mao B, et al. Insect Sci, 2022 Dec. PMID 35271765
  2. A family of Drosophila genes encoding quaking-related maxi-KH domains. Fyrberg C, et al. Biochem Genet, 1998 Feb. PMID 9562906
  3. Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program. Harsh S, et al. PLoS Biol, 2025 Dec. PMID 41411219, Free PMC Article
  4. Drosophila modeling to identify causative genes and reveal the underlying molecular mechanisms for primary ovarian insufficiency. Ma Y, et al. J Mol Med (Berl), 2025 Feb. PMID 39853375
  5. Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila. Stoiber MH, et al. Genome Res, 2015 Nov. PMID 26294687, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female somatic sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
quaking related 58E-2
Names
CG5821-PA
CG5821-PB
CG5821-PC
qkr58E-2-PA
qkr58E-2-PB
qkr58E-2-PC

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22415560..22419001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299795.1 → NP_001286724.1  quaking related 58E-2, isoform C

    See identical proteins and their annotated locations for NP_001286724.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BID2, Q9W254
    Conserved Domains (1) summary
    cd02395
    Location:129 → 244
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

  2. NM_001299796.1 → NP_001286725.1  quaking related 58E-2, isoform B

    See identical proteins and their annotated locations for NP_001286725.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BID2, Q9W254
    Conserved Domains (1) summary
    cd02395
    Location:129 → 244
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

  3. NM_079086.3 → NP_523810.2  quaking related 58E-2, isoform A

    See identical proteins and their annotated locations for NP_523810.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BID2, Q9W254
    Related
    FBpp0071739
    Conserved Domains (1) summary
    cd02395
    Location:129 → 244
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O44432 O44432
Q9W254 Q9W254

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