TRIM73 tripartite motif containing 73 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM73provided by HGNC
Official Full Name: tripartite motif containing 73provided by HGNC
Primary source: HGNC:HGNC:18162
See related: Ensembl:ENSG00000178809 MIM:612549; AllianceGenome:HGNC:18162
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TRIM50B
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Located in cytosol. [provided by Alliance of Genome Resources, May 2025]
Expression: Broad expression in testis (RPKM 4.9), stomach (RPKM 3.6) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 7q11.23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (75395629..75405605)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (76682903..76692889)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (75024903..75034888)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maps within the critical region of Williams-Beuren syndrome.
Title: Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

GDB:434012 (e-PCR)
- UniSTS:157204

GDB:4585495 (e-PCR)
- UniSTS:25903

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

GDB:314949 (e-PCR)
- UniSTS:156503

L18426 (e-PCR)
- UniSTS:34648

STS-N62712 (e-PCR)
- UniSTS:50779

L17709 (e-PCR)
- UniSTS:42599

GDB:4585241 (e-PCR)
- UniSTS:42181

D11S3316 (e-PCR)
- UniSTS:152558

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: tripartite motif-containing protein 73

Names: tripartite motif-containing protein 50B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198924.4 → NP_944606.2 tripartite motif-containing protein 73

See identical proteins and their annotated locations for NP_944606.2

Status: VALIDATED

Source sequence(s)

AC211429, AF498998, AK126632, DA452220

Consensus CDS

CCDS34665.1

UniProtKB/Swiss-Prot

Q86UV7, Q8N0S3

UniProtKB/TrEMBL

I3L0H3

Related

ENSP00000318615.3, ENST00000323819.8

Conserved Domains (2) summary

cd00021
Location:90 → 125

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:15 → 60

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...