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SIMC1 SUMO interacting motifs containing 1 [ Homo sapiens (human) ]

Gene ID: 375484, updated on 18-Aug-2020

Summary

Official Symbol
SIMC1provided by HGNC
Official Full Name
SUMO interacting motifs containing 1provided by HGNC
Primary source
HGNC:HGNC:24779
See related
Ensembl:ENSG00000170085 MIM:618102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OOMA1; PLEIAD; C5orf25
Expression
Broad expression in testis (RPKM 8.3), ovary (RPKM 7.8) and 23 other tissues See more
Orthologs

Genomic context

See SIMC1 in Genome Data Viewer
Location:
5q35.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (176238371..176345991)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175665370..175772992)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986487 Neighboring gene selenophosphate synthetase 1 pseudogene 3 Neighboring gene centrosomal protein 192kDa pseudogene Neighboring gene BRCA1/BRCA2-containing complex subunit 3 pseudogene 1 Neighboring gene KIAA1191 Neighboring gene microRNA 1271 Neighboring gene ADP ribosylation factor like GTPase 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44216, FLJ56998, MGC33586, MGC40402, MGC90345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SUMO polymer binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO polymer binding IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SUMO-interacting motif-containing protein 1
Names
oocyte maturation associated 1
platform element for inhibition of autolytic degradation

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308195.2NP_001295124.1  SUMO-interacting motif-containing protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK299336, BC032390, HY028607, KF151170
    Consensus CDS
    CCDS78088.1
    UniProtKB/Swiss-Prot
    Q8NDZ2
    UniProtKB/TrEMBL
    B4DRM7, F6R0L0, R9TJD7
    Related
    ENSP00000410552.3, ENST00000429602.7
    Conserved Domains (1) summary
    PHA03307
    Location:142368
    PHA03307; transcriptional regulator ICP4; Provisional
  2. NM_001308196.2NP_001295125.1  SUMO-interacting motif-containing protein 1 isoform c

    See identical proteins and their annotated locations for NP_001295125.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains two additional exons in the 5' region, resulting in differences in the 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC139493, AK299336, BC032390, BC037298, HY028607
    Consensus CDS
    CCDS78089.1
    UniProtKB/Swiss-Prot
    Q8NDZ2
    UniProtKB/TrEMBL
    B4DRM7
    Related
    ENSP00000406571.1, ENST00000443967.5
    Conserved Domains (1) summary
    PHA03307
    Location:124349
    PHA03307; transcriptional regulator ICP4; Provisional
  3. NM_001308200.2NP_001295129.1  SUMO-interacting motif-containing protein 1 isoform d

    See identical proteins and their annotated locations for NP_001295129.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several 5' exons but contains an alternate 5' terminal exon, resulting in differences in the 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC139493, BC073880
    Consensus CDS
    CCDS78090.1
    UniProtKB/Swiss-Prot
    Q8NDZ2
    Related
    ENSP00000331311.4, ENST00000332772.4
  4. NM_198567.6NP_940969.3  SUMO-interacting motif-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    BC066980, BC073880, HY028607
    Consensus CDS
    CCDS4398.2
    UniProtKB/Swiss-Prot
    Q8NDZ2
    Related
    ENSP00000342075.6, ENST00000341199.10

RNA

  1. NR_131772.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' region and splices out a segment of the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC066980, BU684936, HY028607, KF151170

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    176238371..176345991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009455.1XP_016864944.1  SUMO-interacting motif-containing protein 1 isoform X5

  2. XM_017009454.1XP_016864943.1  SUMO-interacting motif-containing protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q8NDZ2
    Conserved Domains (1) summary
    PHA03307
    Location:124349
    PHA03307; transcriptional regulator ICP4; Provisional
  3. XM_011534554.2XP_011532856.1  SUMO-interacting motif-containing protein 1 isoform X2

    Conserved Domains (1) summary
    PHA03307
    Location:146372
    PHA03307; transcriptional regulator ICP4; Provisional
  4. XM_011534553.2XP_011532855.1  SUMO-interacting motif-containing protein 1 isoform X1

    Conserved Domains (1) summary
    PHA03307
    Location:146372
    PHA03307; transcriptional regulator ICP4; Provisional
  5. XM_011534556.2XP_011532858.1  SUMO-interacting motif-containing protein 1 isoform X4

    Conserved Domains (1) summary
    PHA03307
    Location:119345
    PHA03307; transcriptional regulator ICP4; Provisional
  6. XM_017009456.1XP_016864945.1  SUMO-interacting motif-containing protein 1 isoform X5

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