These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_034036.1 RefSeqGene
- Range
-
5046..578246
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001164664.2 → NP_001158136.1 microtubule-associated serine/threonine-protein kinase 4 isoform c
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
- Source sequence(s)
-
AC008872, AC008920, AC016634, AC044799, AC092373
- Consensus CDS
-
CCDS54861.1
- UniProtKB/TrEMBL
-
J3QT34
- Related
- ENSP00000385727.1, ENST00000403625.6
- Conserved Domains (4) summary
-
- cd00992
Location:1146 → 1224
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd05609
Location:569 → 848
- STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
- pfam08926
Location:258 → 531
- DUF1908; Domain of unknown function (DUF1908)
- cl26464
Location:1811 → 2189
- Atrophin-1; Atrophin-1 family
-
NM_001290226.2 → NP_001277155.1 microtubule-associated serine/threonine-protein kinase 4 isoform d
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) represents use of an alternate promoter, differs in the 5' UTR, uses a downstream start codon, and has an alternate in-frame exon compared to variant 3. The encoded protein (isoform d) has a shorter and distinct N-terminus compared to isoform c.
- Source sequence(s)
-
AB002301, AC044799, AK299538
- UniProtKB/Swiss-Prot
-
O15021
- UniProtKB/TrEMBL
-
B4DS23
- Conserved Domains (4) summary
-
- smart00220
Location:364 → 637
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd00992
Location:940 → 1018
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd05609
Location:363 → 642
- STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
- pfam08926
Location:49 → 325
- DUF1908; Domain of unknown function (DUF1908)
-
NM_001290227.2 → NP_001277156.1 microtubule-associated serine/threonine-protein kinase 4 isoform e
See identical proteins and their annotated locations for NP_001277156.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) represents use of an alternate promoter, differs in the 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon compared to variant 3. The encoded protein (isoform e) has a shorter and distinct N-terminus compared to isoform c.
- Source sequence(s)
-
AC044799, AK296707
- UniProtKB/TrEMBL
-
B4DKT8
- Conserved Domains (4) summary
-
- smart00220
Location:376 → 649
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd00992
Location:885 → 963
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd05609
Location:375 → 654
- STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
- pfam08926
Location:64 → 337
- DUF1908; Domain of unknown function (DUF1908)
-
NM_001290228.2 → NP_001277157.1 microtubule-associated serine/threonine-protein kinase 4 isoform f
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) uses a distinct 3' coding region and 3' UTR compared to variant 3. The encoded protein (isoform f) has a shorter and distinct C-terminus compared to isoform c.
- Source sequence(s)
-
AC008872, AC092373, AY439222, BC033215, CB044105
- Consensus CDS
-
CCDS78015.1
- UniProtKB/Swiss-Prot
-
O15021
- UniProtKB/TrEMBL
- E7EX28, Q6T2V4
- Related
- ENSP00000384547.1, ENST00000406039.5
-
NM_001297651.2 → NP_001284580.1 microtubule-associated serine/threonine-protein kinase 4 isoform g
See identical proteins and their annotated locations for NP_001284580.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (7) represents use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate 5' exon, compared to variant 3. The encoded isoform (g) is shorter and has a distinct N-terminus, compared to isoform c.
- Source sequence(s)
-
AC044799, AK057601, AK299706, AY830839, BF515864
- Consensus CDS
-
CCDS75254.1
- UniProtKB/Swiss-Prot
-
O15021
- UniProtKB/TrEMBL
-
B4DSE5
- Related
- ENSP00000261569.7, ENST00000261569.11
- Conserved Domains (4) summary
-
- smart00220
Location:376 → 649
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd00992
Location:952 → 1030
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd05609
Location:375 → 654
- STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
- pfam08926
Location:64 → 337
- DUF1908; Domain of unknown function (DUF1908)
-
NM_015183.3 → NP_055998.1 microtubule-associated serine/threonine-protein kinase 4 isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and includes an alternate in-frame exon in the 5' coding region, compared to variant 3. The resulting isoform (a) has a shorter N-terminus and includes an additional segment near the N-terminus, compared to isoform c.
- Source sequence(s)
-
AC016634, AC044799, AY830839
- Consensus CDS
-
CCDS47225.1
- UniProtKB/Swiss-Prot
-
O15021
- Related
- ENSP00000384313.1, ENST00000403666.5
- Conserved Domains (4) summary
-
- smart00220
Location:381 → 654
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd00992
Location:957 → 1035
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd05609
Location:380 → 659
- STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
- pfam08926
Location:69 → 342
- DUF1908; Domain of unknown function (DUF1908)
-
NM_198828.3 → NP_942123.1 microtubule-associated serine/threonine-protein kinase 4 isoform b
See identical proteins and their annotated locations for NP_942123.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses a distinct 3' coding region and 3' UTR, compared to variant 3. The resulting isoform (b) has a substantially shorter and distinct C-terminus, compared to isoform c.
- Source sequence(s)
-
BC033215
- Consensus CDS
-
CCDS47224.1
- UniProtKB/Swiss-Prot
-
O15021
- Related
- ENSP00000385088.1, ENST00000406374.5
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p13 Primary Assembly
Genomic
-
NC_000005.10 Reference GRCh38.p13 Primary Assembly
- Range
-
66596354..67169595
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_024446044.1 → XP_024301812.1 microtubule-associated serine/threonine-protein kinase 4 isoform X1
- Conserved Domains (4) summary
-
- cd00992
Location:1218 → 1296
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd05609
Location:641 → 920
- STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
- pfam08926
Location:330 → 603
- DUF1908; Domain of unknown function (DUF1908)
- cl26464
Location:1883 → 2261
- Atrophin-1; Atrophin-1 family
-
XM_017009452.1 → XP_016864941.1 microtubule-associated serine/threonine-protein kinase 4 isoform X10
-
XM_017009450.1 → XP_016864939.1 microtubule-associated serine/threonine-protein kinase 4 isoform X5
-
XM_017009451.1 → XP_016864940.1 microtubule-associated serine/threonine-protein kinase 4 isoform X9
-
XM_011543385.3 → XP_011541687.1 microtubule-associated serine/threonine-protein kinase 4 isoform X6
- Conserved Domains (4) summary
-
- smart00220
Location:361 → 634
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd00992
Location:937 → 1015
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd05609
Location:360 → 639
- STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
- pfam08926
Location:49 → 322
- DUF1908; Domain of unknown function (DUF1908)
-
XM_017009449.1 → XP_016864938.1 microtubule-associated serine/threonine-protein kinase 4 isoform X2
- Related
- ENSP00000384099.1, ENST00000405643.5
-
XM_006714606.3 → XP_006714669.1 microtubule-associated serine/threonine-protein kinase 4 isoform X3
See identical proteins and their annotated locations for XP_006714669.1
- UniProtKB/Swiss-Prot
-
O15021
- Conserved Domains (4) summary
-
- smart00220
Location:376 → 649
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd00992
Location:952 → 1030
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd05609
Location:375 → 654
- STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
- pfam08926
Location:64 → 337
- DUF1908; Domain of unknown function (DUF1908)
-
XM_006714610.2 → XP_006714673.1 microtubule-associated serine/threonine-protein kinase 4 isoform X8
See identical proteins and their annotated locations for XP_006714673.1
- Conserved Domains (4) summary
-
- smart00220
Location:376 → 649
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd00992
Location:885 → 963
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd05609
Location:375 → 654
- STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
- pfam08926
Location:64 → 337
- DUF1908; Domain of unknown function (DUF1908)
-
XM_017009453.1 → XP_016864942.1 microtubule-associated serine/threonine-protein kinase 4 isoform X10
-
XM_011543386.2 → XP_011541688.1 microtubule-associated serine/threonine-protein kinase 4 isoform X7
- Conserved Domains (4) summary
-
- smart00220
Location:358 → 631
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd00992
Location:934 → 1012
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd05609
Location:357 → 636
- STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
- pfam08926
Location:46 → 319
- DUF1908; Domain of unknown function (DUF1908)
-
XM_011543384.2 → XP_011541686.1 microtubule-associated serine/threonine-protein kinase 4 isoform X4
- Conserved Domains (4) summary
-
- smart00220
Location:370 → 643
- S_TKc; Serine/Threonine protein kinases, catalytic domain
- cd00992
Location:946 → 1024
- PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
- cd05609
Location:369 → 648
- STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
- pfam08926
Location:58 → 331
- DUF1908; Domain of unknown function (DUF1908)