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Alp2 Alkaline phosphatase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37539, updated on 5-Jan-2022

Summary

Official Symbol
Alp2provided by FlyBase
Official Full Name
Alkaline phosphatase 2provided by FlyBase
Primary source
FLYBASE:FBgn0283480
Locus tag
Dmel_CG3290
Gene type
protein coding
RNA name
alkaline phosphatase 2
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aph-2; CG3290; Dmel\CG3290
Summary
Enables alkaline phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in cell surface. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPL (alkaline phosphatase, biomineralization associated); ALPG (alkaline phosphatase, germ cell); and ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See Alp2 in Genome Data Viewer
Location:
58D1-58D1; 2-99 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22206005..22207987, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18093510..18095492, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Secreted Wg-interacting molecule Neighboring gene antisense RNA:CR45376 Neighboring gene Alkaline phosphatase 7 Neighboring gene Alkaline phosphatase 8 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alkaline phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alkaline phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alkaline phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
alkaline phosphatase 2
Names
Alp2-PA
CG3290-PA
NP_611654.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22206005..22207987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137810.1NP_611654.1  alkaline phosphatase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611654.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W274
    Related
    FBpp0071695, FBtr0071782
    Conserved Domains (1) summary
    cl23718
    Location:89525
    ALP_like; alkaline phosphatases and sulfatases
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