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NRROS negative regulator of reactive oxygen species [ Homo sapiens (human) ]

Gene ID: 375387, updated on 24-Nov-2020

Summary

Official Symbol
NRROSprovided by HGNC
Official Full Name
negative regulator of reactive oxygen speciesprovided by HGNC
Primary source
HGNC:HGNC:24613
See related
Ensembl:ENSG00000174004 MIM:615322
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GARPL1; LRRC33; SENEBAC; UNQ3030; ELLP3030
Expression
Broad expression in bone marrow (RPKM 13.1), spleen (RPKM 8.2) and 22 other tissues See more
Orthologs

Genomic context

See NRROS in Genome Data Viewer
Location:
3q29
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (196639694..196662004)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196366656..196388875)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene F-box protein 45 Neighboring gene long intergenic non-protein coding RNA 1063 Neighboring gene RNA, U6 small nuclear 646, pseudogene Neighboring gene centrosomal protein 19 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class X

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC50789

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transforming growth factor beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
microglia development ISS
Inferred from Sequence or Structural Similarity
more info
 
sequestering of TGFbeta in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
superoxide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT superoxide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
transforming growth factor beta1 activation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transforming growth factor beta activator LRRC33
Names
leucine-rich repeat-containing protein 33

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198565.3NP_940967.1  transforming growth factor beta activator LRRC33 precursor

    See identical proteins and their annotated locations for NP_940967.1

    Status: VALIDATED

    Source sequence(s)
    AA534416, AC055725, BC044233, BQ070837, HY084054
    Consensus CDS
    CCDS3319.1
    UniProtKB/Swiss-Prot
    Q86YC3
    Related
    ENSP00000328625.4, ENST00000328557.5
    Conserved Domains (3) summary
    cd00116
    Location:357594
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:330353
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:157217
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    196639694..196662004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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