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Vps35 Vacuolar protein sorting 35 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37536, updated on 26-Aug-2021

Summary

Official Symbol
Vps35provided by FlyBase
Official Full Name
Vacuolar protein sorting 35provided by FlyBase
Primary source
FLYBASE:FBgn0034708
Locus tag
Dmel_CG5625
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5625; Dmel\CG5625; DmVps35; dvps35; dVPS35; Dvps35; DVps35; vps35; VPS35
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Genomic context

See Vps35 in Genome Data Viewer
Location:
58C7-58C7; 2-98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22185972..22189886)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18073477..18077391)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 16 Neighboring gene Secreted Wg-interacting molecule Neighboring gene ncRNA Neighboring gene antisense RNA:CR45376

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Vps35 gene: The Vps35 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in central nervous system neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Wnt protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endosome to plasma membrane protein transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of endosome to plasma membrane protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to rotenone IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde transport, endosome to Golgi IC
Inferred by Curator
more info
PubMed 
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
part_of retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of retromer complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of retromer, cargo-selective complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in subsynaptic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vacuolar protein sorting 35
Names
CG5625-PA
CG5625-PB
Vps35-PA
Vps35-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22185972..22189886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166518.3NP_726175.3  vacuolar protein sorting 35, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726175.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W277
    Related
    FBpp0071685, FBtr0071771
    Conserved Domains (1) summary
    pfam03635
    Location:32777
    Vps35; Vacuolar protein sorting-associated protein 35
  2. NM_137807.4NP_611651.4  vacuolar protein sorting 35, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611651.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KVL7
    Related
    FBpp0071686, FBtr0071772
    Conserved Domains (1) summary
    pfam03635
    Location:13758
    Vps35; Vacuolar protein sorting-associated protein 35
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