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Fmr1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37528, updated on 26-Aug-2021

Summary

Official Symbol
Fmr1provided by FlyBase
Primary source
FLYBASE:FBgn0028734
Locus tag
Dmel_CG6203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AT24755; BcDNA:GM08679; cg6203; CG6203; dfmr; dFMR; dfmr1; dFmr1; dFMR1; DFmr1; dFmrp; dFMRP; DFMRP; dfxr; dFXR; dfxr1; dFXR1; dFXRP; Dmel\CG6203; dmfr1; EP(3)3517; fmr; FMR; fmr1; FMR1; Fmrp; FMRp; FMRP; FXR
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Genomic context

See Fmr1 in Genome Data Viewer
Location:
85F10-85F12; 3-49 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10101420..10110121, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5927142..5935843, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43459 Neighboring gene mir-277 stem loop Neighboring gene mir-34 stem loop Neighboring gene Carbonic anhydrase 7 Neighboring gene gamma Soluble NSF attachment protein 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DEAD/H-box RNA helicase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables N6-methyladenosine-containing RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
enables translation regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellularization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellularization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of touch IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene silencing by RNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ-line cyst formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in germ-line cyst formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germarium-derived oocyte fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in grooming behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in habituation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterochromatin assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotion TAS
Traceable Author Statement
more info
PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in medium-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of axon extension IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of translation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in olfactory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in olfactory learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oocyte dorsal/ventral axis specification IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT involved_in phototaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pole cell formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in post-embryonic digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendritic spine development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitotic cell cycle, embryonic IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of modification of synaptic structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse structural plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of translation at postsynapse, modulating synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to odorant IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in short-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in short-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse pruning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle budding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in terminal button organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in P granule IDA
Inferred from Direct Assay
more info
PubMed 
part_of RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of messenger ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuronal ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane bounded cell projection cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of polysome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Fmr1
Names
CG6203-PA
CG6203-PB
CG6203-PC
CG6203-PD
CG6203-PE
CG6203-PF
CG6203-PG
CG6203-PH
CG6203-PI
CG6203-PJ
CG6203-PK
Fmr1-PA
Fmr1-PB
Fmr1-PC
Fmr1-PD
Fmr1-PE
Fmr1-PF
Fmr1-PG
Fmr1-PH
Fmr1-PI
Fmr1-PJ
Fmr1-PK
Fragile-X mental retardation 1
Fragile-X mental retardation protein
Fragile-X-related
cg 6203 gene product from transcript cg6203-rc
dFMR
dFmr1
drosophila fragile X mental retardation protein
fragile X
fragile X mental retardation
fragile X mental retardation 1
fragile X mental retardation gene
fragile X mental retardation protein
fragile X mental retardation protein 1
fragile X mental retardation related 1
fragile X protein
fragile X related protein
fragile X retardation 1 protein
fragile X-related
fragile x related
fragile-X
NP_001247017.1
  • non-AUG (CUG) translation initiation
NP_001262447.1
  • non-AUG (CUG) translation initiation

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10101420..10110121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169324.2NP_731443.1  Fmr1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731443.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    UniProtKB/TrEMBL
    A0A126GUS7
    Related
    FBpp0081676, FBtr0082198
    Conserved Domains (3) summary
    smart00743
    Location:59115
    Agenet; Tudor-like domain present in plant sequences
    pfam00013
    Location:289356
    KH_1; KH domain
    pfam12235
    Location:359480
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
  2. NM_001260088.1NP_001247017.1  Fmr1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247017.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K618
    Related
    FBpp0300445, FBtr0308123
    Conserved Domains (3) summary
    smart00743
    Location:107163
    Agenet; Tudor-like domain present in plant sequences
    pfam00013
    Location:337404
    KH_1; KH domain
    pfam12235
    Location:407528
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
  3. NM_169326.3NP_731445.1  Fmr1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731445.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    Related
    FBpp0081678, FBtr0082200
    Conserved Domains (3) summary
    smart00743
    Location:2177
    Agenet; Tudor-like domain present in plant sequences
    pfam00013
    Location:251318
    KH_1; KH domain
    pfam12235
    Location:321442
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
  4. NM_001275519.1NP_001262448.1  Fmr1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262448.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFN9
    Related
    FBpp0307053, FBtr0335049
    Conserved Domains (3) summary
    smart00743
    Location:2177
    Agenet; Tudor-like domain present in plant sequences
    pfam00013
    Location:251314
    KH_1; KH domain
    pfam12235
    Location:317438
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
  5. NM_001170109.2NP_001163580.1  Fmr1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163580.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3LF78
    Related
    FBpp0290600, FBtr0301386
    Conserved Domains (3) summary
    smart00743
    Location:2177
    Agenet; Tudor-like domain present in plant sequences
    pfam00013
    Location:251321
    KH_1; KH domain
    pfam12235
    Location:324445
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
  6. NM_137801.4NP_611645.1  Fmr1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611645.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    Related
    FBpp0081675, FBtr0082197
    Conserved Domains (3) summary
    smart00743
    Location:59115
    Agenet; Tudor-like domain present in plant sequences
    pfam00013
    Location:289359
    KH_1; KH domain
    pfam12235
    Location:362483
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
  7. NM_001316514.1NP_001303443.1  Fmr1, isoform J [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    UniProtKB/TrEMBL
    A0A126GUS7
    Related
    FBpp0312465, FBtr0347104
    Conserved Domains (3) summary
    smart00743
    Location:59115
    Agenet; Tudor-like domain present in plant sequences
    pfam00013
    Location:289356
    KH_1; KH domain
    pfam12235
    Location:359480
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
  8. NM_001316515.1NP_001303444.1  Fmr1, isoform K [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    UniProtKB/TrEMBL
    A0A126GUS7
    Related
    FBpp0312466, FBtr0347105
    Conserved Domains (3) summary
    smart00743
    Location:59115
    Agenet; Tudor-like domain present in plant sequences
    pfam00013
    Location:289356
    KH_1; KH domain
    pfam12235
    Location:359480
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
  9. NM_169325.3NP_731444.1  Fmr1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731444.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    UniProtKB/TrEMBL
    A0A126GUS7
    Related
    FBpp0081677, FBtr0082199
    Conserved Domains (3) summary
    smart00743
    Location:59115
    Agenet; Tudor-like domain present in plant sequences
    pfam00013
    Location:289356
    KH_1; KH domain
    pfam12235
    Location:359480
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
  10. NM_169327.2NP_731446.1  Fmr1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731446.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    Related
    FBpp0081674, FBtr0082196
    Conserved Domains (4) summary
    smart00743
    Location:59115
    Agenet; Tudor-like domain present in plant sequences
    cd00105
    Location:289350
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:223282
    KH_1; KH domain
    pfam12235
    Location:352473
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
  11. NM_001275518.1NP_001262447.1  Fmr1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262447.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGP6
    Related
    FBpp0307052, FBtr0335048
    Conserved Domains (4) summary
    smart00743
    Location:107163
    Agenet; Tudor-like domain present in plant sequences
    cd00105
    Location:337398
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:271330
    KH_1; KH domain
    pfam12235
    Location:400521
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
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