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ARF1 ADP ribosylation factor 1 [ Homo sapiens (human) ]

Gene ID: 375, updated on 14-Jun-2020

Summary

Official Symbol
ARF1provided by HGNC
Official Full Name
ADP ribosylation factor 1provided by HGNC
Primary source
HGNC:HGNC:652
See related
Ensembl:ENSG00000143761 MIM:103180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PVNH8
Summary
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 152.3), thyroid (RPKM 137.5) and 25 other tissues See more
Orthologs

Genomic context

See ARF1 in Genome Data Viewer
Location:
1q42.13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (228082660..228099212)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228270361..228286913)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Wnt family member 3A Neighboring gene long intergenic non-protein coding RNA 2809 Neighboring gene microRNA 3620 Neighboring gene chromosome 1 open reading frame 35 Neighboring gene mitochondrial ribosomal protein L55

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ADP-ribosylation factor 1 (ARF1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Functional ARF1 is required for HIV-1 Nef-dependent endogenous HLA-A2 and CD4 downregulation in HIV-infected primary T cells PubMed
nef Dominant active ARF1 (Q71L) potently stabilizes interactions among AP-1 mu1, HIV-1 Nef, and HLA-A2 and that the formation of a static complex sequesters necessary trafficking components PubMed
nef Nef binds GTPase ARF1 directly via residues E154 and E155 and recruits the GTPase to endosomal membranes PubMed
Pr55(Gag) gag GGA-mediated inhibition of virus particle release results from ARF1 sequestration, suggesting the interaction between HIV-1 Gag and ARF1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
 
RNA binding HDA PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase D activator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
Golgi to transport vesicle transport IEA
Inferred from Electronic Annotation
more info
 
actin filament organization IEA
Inferred from Electronic Annotation
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
cellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic spine organization ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-term synaptic depression ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosomal membrane organization IEA
Inferred from Electronic Annotation
more info
 
mitotic cleavage furrow ingression IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
positive regulation of ER to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of late endosome to lysosome transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
postsynaptic actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
regulation of Arp2/3 complex-mediated actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of defense response to virus by virus TAS
Traceable Author Statement
more info
 
regulation of phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle budding IEA
Inferred from Electronic Annotation
more info
 
very-low-density lipoprotein particle assembly IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
COPI-coated vesicle IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
late endosome IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
sarcomere IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024226.1NP_001019397.1  ADP-ribosylation factor 1

    See identical proteins and their annotated locations for NP_001019397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate and shorter 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK000620, BF337061, BM844480
    Consensus CDS
    CCDS1565.1
    UniProtKB/Swiss-Prot
    P84077
    UniProtKB/TrEMBL
    A0A024R3Q3
    Related
    ENSP00000442980.1, ENST00000540651.5
    Conserved Domains (1) summary
    smart00177
    Location:5179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor
  2. NM_001024227.1NP_001019398.1  ADP-ribosylation factor 1

    See identical proteins and their annotated locations for NP_001019398.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AK000620, BF337061, BG421840, BQ935470
    Consensus CDS
    CCDS1565.1
    UniProtKB/Swiss-Prot
    P84077
    UniProtKB/TrEMBL
    A0A024R3Q3
    Related
    ENSP00000440005.1, ENST00000541182.1
    Conserved Domains (1) summary
    smart00177
    Location:5179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor
  3. NM_001024228.2NP_001019399.1  ADP-ribosylation factor 1

    See identical proteins and their annotated locations for NP_001019399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK000620, AL136379, BF337061, BM353046, BQ949763
    Consensus CDS
    CCDS1565.1
    UniProtKB/Swiss-Prot
    P84077
    UniProtKB/TrEMBL
    A0A024R3Q3
    Conserved Domains (1) summary
    smart00177
    Location:5179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor
  4. NM_001658.4NP_001649.1  ADP-ribosylation factor 1

    See identical proteins and their annotated locations for NP_001649.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate and shorter 5' UTR, as compared to variant 1.
    Source sequence(s)
    AK000620, BF337061
    Consensus CDS
    CCDS1565.1
    UniProtKB/Swiss-Prot
    P84077
    UniProtKB/TrEMBL
    A0A024R3Q3
    Related
    ENSP00000272102.5, ENST00000272102.10
    Conserved Domains (1) summary
    smart00177
    Location:5179
    ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    228082660..228099212
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001233.1XP_016856722.1  ADP-ribosylation factor 1 isoform X1

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