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MIGA1 mitoguardin 1 [ Homo sapiens (human) ]

Gene ID: 374986, updated on 13-Mar-2020

Summary

Official Symbol
MIGA1provided by HGNC
Official Full Name
mitoguardin 1provided by HGNC
Primary source
HGNC:HGNC:24741
See related
Ensembl:ENSG00000180488 MIM:616773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM73A
Expression
Ubiquitous expression in brain (RPKM 8.8), thyroid (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See MIGA1 in Genome Data Viewer
Location:
1p31.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (77779624..77879540)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78245309..78345225)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 33 Neighboring gene actin gamma 1 pseudogene 21 Neighboring gene RNA, 5S ribosomal pseudogene 21 Neighboring gene axin interactor, dorsalization associated pseudogene Neighboring gene nuclear speckle splicing regulatory protein 1 pseudogene 1 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 25 Neighboring gene NEXN antisense RNA 1 Neighboring gene nexilin F-actin binding protein Neighboring gene far upstream element binding protein 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member B4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35093, DKFZp686M07166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial fusion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mitoguardin 1
Names
family with sequence similarity 73, member A
protein FAM73A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270384.1NP_001257313.1  mitoguardin 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138392, AK296411, BC144167, BX537792, CA436207
    Consensus CDS
    CCDS72809.1
    UniProtKB/Swiss-Prot
    Q8NAN2
    UniProtKB/TrEMBL
    B4DK63, B7ZLZ8, F8W7S1
    Related
    ENSP00000393675.3, ENST00000443751.3
    Conserved Domains (1) summary
    pfam10265
    Location:59604
    DUF2217; Uncharacterized conserved protein (DUF2217)
  2. NM_001363583.1NP_001350512.1  mitoguardin 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114487, AC138392
    Consensus CDS
    CCDS85989.1
    Related
    ENSP00000494964.1, ENST00000645526.1
    Conserved Domains (1) summary
    pfam10265
    Location:27571
    Miga; Mitoguardin
  3. NM_001363584.1NP_001350513.1  mitoguardin 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114487, AC138392
    Consensus CDS
    CCDS85989.1
    Related
    ENSP00000495239.1, ENST00000646892.1
    Conserved Domains (1) summary
    pfam10265
    Location:27571
    Miga; Mitoguardin
  4. NM_001363586.1NP_001350515.1  mitoguardin 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114487, AC138392
    Consensus CDS
    CCDS85989.1
    Conserved Domains (1) summary
    pfam10265
    Location:27571
    Miga; Mitoguardin
  5. NM_198549.3NP_940951.1  mitoguardin 1 isoform 1

    See identical proteins and their annotated locations for NP_940951.1

    Status: VALIDATED

    Source sequence(s)
    AC138392, BX537792, CA436207
    Consensus CDS
    CCDS681.1
    UniProtKB/Swiss-Prot
    Q8NAN2
    Related
    ENSP00000359827.3, ENST00000370791.7
    Conserved Domains (1) summary
    pfam10265
    Location:59603
    DUF2217; Uncharacterized conserved protein (DUF2217)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    77779624..77879540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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