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MROH7 maestro heat like repeat family member 7 [ Homo sapiens (human) ]

Gene ID: 374977, updated on 13-Mar-2020

Summary

Official Symbol
MROH7provided by HGNC
Official Full Name
maestro heat like repeat family member 7provided by HGNC
Primary source
HGNC:HGNC:24802
See related
Ensembl:ENSG00000184313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEATR8; C1orf175
Expression
Biased expression in testis (RPKM 43.4), thyroid (RPKM 2.8) and 1 other tissue See more
Orthologs

Genomic context

See MROH7 in Genome Data Viewer
Location:
1p32.3
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (54641740..54710267)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55107427..55175939)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 63 Neighboring gene acyl-CoA thioesterase 11 Neighboring gene family with sequence similarity 151 member A Neighboring gene MROH7-TTC4 readthrough (NMD candidate) Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene prolyl-tRNA synthetase 2, mitochondrial

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough MROH7-TTC4

Readthrough gene: MROH7-TTC4, Included gene: TTC4

Potential readthrough

Included gene: ACOT11

Homology

Clone Names

  • FLJ45063, FLJ46354, DKFZp434K085, DKFZp686L2332, DKFZp781B0622

Gene Ontology Provided by GOA

Component Evidence Code Pubs
extracellular space HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
maestro heat-like repeat-containing protein family member 7
Names
HEAT repeat-containing protein 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039464.4NP_001034553.3  maestro heat-like repeat-containing protein family member 7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL139244, AL590093
    Consensus CDS
    CCDS41342.2
    Related
    ENSP00000396622.2, ENST00000421030.7
  2. NM_001291332.1NP_001278261.1  maestro heat-like repeat-containing protein family member 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, contains multiple differences in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK301894, AK302446, AL042708, BC095478, DB040876, DB457600, HY195227
    UniProtKB/TrEMBL
    B4DXB3, B7Z7S6
    Related
    ENSP00000387048.1, ENST00000409996.5

RNA

  1. NR_026782.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 5'-most exon and in a central exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK302446, AL042708, AL832492, BC095478, BC143891, DB040876, DB457600, HY195227
    Related
    ENST00000422659.5
  2. NR_111931.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK302446, AL042708, AL139244, BC095478, BC144516, DB040876, DB457600, HY195227
    Related
    ENST00000440047.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    54641740..54710267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198547.1: Suppressed sequence

    Description
    NM_198547.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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