U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DRAXIN dorsal inhibitory axon guidance protein [ Homo sapiens (human) ]

Gene ID: 374946, updated on 10-Dec-2024

Summary

Official Symbol
DRAXINprovided by HGNC
Official Full Name
dorsal inhibitory axon guidance proteinprovided by HGNC
Primary source
HGNC:HGNC:25054
See related
Ensembl:ENSG00000162490 MIM:612682; AllianceGenome:HGNC:25054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ3119; neucrin; AGPA3119; C1orf187
Summary
Enables molecular adaptor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and nervous system development. Predicted to act upstream of or within negative regulation of axon extension and negative regulation of hippocampal neuron apoptotic process. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DRAXIN in Genome Data Viewer
Location:
1p36.22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11686635..11725857)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11230691..11269932)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11751767..11785914)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 267 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:11718034-11719233 Neighboring gene F-box protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 168 Neighboring gene F-box protein 44 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 170 Neighboring gene F-box protein 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11743170-11743751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11744701-11745201 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11750065-11750574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11750575-11751082 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11764337-11764964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11786269-11787256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 172 Neighboring gene angiotensin II receptor associated protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11808242-11808918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11808919-11809595 Neighboring gene atrophin-1-like Neighboring gene chromosome 1 open reading frame 167

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Clone Names

  • FLJ34999, MGC117222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity EXP
Inferred from Experiment
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in anterior commissure morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in commissural neuron differentiation in spinal cord IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in commissural neuron differentiation in spinal cord ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dorsal spinal cord development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dorsal spinal cord development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in forebrain development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in forebrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hippocampal neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of hippocampal neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
draxin
Names
dorsal repulsive axon guidance protein
neural tissue-specific cysteine-rich protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198545.4NP_940947.3  draxin precursor

    See identical proteins and their annotated locations for NP_940947.3

    Status: VALIDATED

    Source sequence(s)
    AL031731, AL953897, AY358750, BC021286, BM928129
    Consensus CDS
    CCDS135.1
    UniProtKB/Swiss-Prot
    B6EV15, Q5SNX0, Q6UWK8, Q8NBI3
    Related
    ENSP00000294485.5, ENST00000294485.6
    Conserved Domains (1) summary
    pfam15550
    Location:38349
    Draxin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    11686635..11725857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001215.2XP_016856704.1  draxin isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    11230691..11269932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336441.1XP_054192416.1  draxin isoform X1