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DRAXIN dorsal inhibitory axon guidance protein [ Homo sapiens (human) ]

Gene ID: 374946, updated on 23-May-2018

Summary

Official Symbol
DRAXINprovided by HGNC
Official Full Name
dorsal inhibitory axon guidance proteinprovided by HGNC
Primary source
HGNC:HGNC:25054
See related
Ensembl:ENSG00000162490 MIM:612682; Vega:OTTHUMG00000002227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ3119; neucrin; AGPA3119; C1orf187
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See DRAXIN in Genome Data Viewer
Location:
1p36.22
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (11686635..11721766)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11751781..11780336)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene F-box protein 2 Neighboring gene F-box protein 44 Neighboring gene F-box protein 6 Neighboring gene mitotic arrest deficient 2 like 2 Neighboring gene angiotensin II receptor associated protein Neighboring gene atrophin-1-like Neighboring gene chromosome 1 open reading frame 167

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

General gene information

Markers

Homology

Clone Names

  • FLJ34999, MGC117222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
commissural neuron differentiation in spinal cord IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
commissural neuron differentiation in spinal cord ISS
Inferred from Sequence or Structural Similarity
more info
 
dorsal spinal cord development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dorsal spinal cord development ISS
Inferred from Sequence or Structural Similarity
more info
 
forebrain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
forebrain development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of axon extension IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
draxin
Names
dorsal repulsive axon guidance protein
neural tissue-specific cysteine-rich protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198545.3NP_940947.3  draxin precursor

    See identical proteins and their annotated locations for NP_940947.3

    Status: VALIDATED

    Source sequence(s)
    AY358750, BC021286, BM928129
    Consensus CDS
    CCDS135.1
    UniProtKB/Swiss-Prot
    Q8NBI3
    Related
    ENSP00000294485.5, OTTHUMP00000002262, ENST00000294485.5, OTTHUMT00000006325
    Conserved Domains (1) summary
    pfam15550
    Location:38349
    Draxin; Draxin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    11686635..11721766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541405.2XP_011539707.1  draxin isoform X1

    Conserved Domains (1) summary
    pfam15550
    Location:116427
    Draxin; Draxin
  2. XM_017001215.1XP_016856704.1  draxin isoform X3

  3. XM_017001214.1XP_016856703.1  draxin isoform X2

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