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ZNF773 zinc finger protein 773 [ Homo sapiens (human) ]

Gene ID: 374928, updated on 23-Nov-2021

Summary

Official Symbol
ZNF773provided by HGNC
Official Full Name
zinc finger protein 773provided by HGNC
Primary source
HGNC:HGNC:30487
See related
Ensembl:ENSG00000152439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF419B
Expression
Ubiquitous expression in thyroid (RPKM 2.6), ovary (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF773 in Genome Data Viewer
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57499938..57518437)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58011306..58029805)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 772 Neighboring gene zinc finger protein 419 Neighboring gene zinc finger protein 549 Neighboring gene zinc finger protein 550

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4728, FLJ00301

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 773
Names
zinc finger protein 419B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304334.2NP_001291263.1  zinc finger protein 773 isoform b

    See identical proteins and their annotated locations for NP_001291263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC003005, AK057209
    Consensus CDS
    CCDS77368.1
    UniProtKB/Swiss-Prot
    Q6PK81
    Related
    ENSP00000469416.1, ENST00000598770.5
    Conserved Domains (5) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:208437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:192212
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:372396
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001304335.3NP_001291264.1  zinc finger protein 773 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' structure, and uses an alternate in-frame splice site in the central coding region, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) is shorter, and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC003005, AC003682, DA650616
    Related
    ENSP00000468846.1, ENST00000599847.5
    Conserved Domains (2) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    pfam01352
    Location:1453
    KRAB; KRAB box
  3. NM_001304336.2NP_001291265.1  zinc finger protein 773 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR, and uses two alternate splice site in the coding region, one of which results in a frameshift compared to variant 1. The encoded isoform (d) is shorter, and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC003005
    Conserved Domains (2) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    pfam01352
    Location:1453
    KRAB; KRAB box
  4. NM_001304337.3NP_001291266.1  zinc finger protein 773 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' structure, and uses an alternate in-frame splice site in the central coding region, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) is shorter, and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC003005, AC003682
    Consensus CDS
    CCDS77369.1
    UniProtKB/TrEMBL
    M0QYZ8
    Related
    ENSP00000470189.1, ENST00000593916.5
    Conserved Domains (2) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    pfam01352
    Location:1453
    KRAB; KRAB box
  5. NM_198542.3NP_940944.1  zinc finger protein 773 isoform a

    See identical proteins and their annotated locations for NP_940944.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC003005, BC005167
    Consensus CDS
    CCDS33134.1
    UniProtKB/Swiss-Prot
    Q6PK81
    Related
    ENSP00000282292.3, ENST00000282292.9
    Conserved Domains (5) summary
    smart00349
    Location:1575
    KRAB; krueppel associated box
    COG5048
    Location:209438
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:193213
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1554
    KRAB; KRAB box
    pfam13465
    Location:373397
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_130705.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC003005, BX365407, BX382674
    Related
    ENST00000597061.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57499938..57518437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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