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B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 [ Homo sapiens (human) ]

Gene ID: 374907, updated on 11-Sep-2019

Summary

Official Symbol
B3GNT8provided by HGNC
Official Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8provided by HGNC
Primary source
HGNC:HGNC:24139
See related
Ensembl:ENSG00000177191 MIM:615357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B3GALT7; BGALT15; beta3Gn-T8
Expression
Broad expression in small intestine (RPKM 4.8), duodenum (RPKM 4.7) and 15 other tissues See more
Orthologs

Genomic context

See B3GNT8 in Genome Data Viewer
Location:
19q13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41425359..41429024, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41931264..41934635, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene exosome component 5 Neighboring gene branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene VISTA enhancer hs1948 Neighboring gene distal membrane arm assembly complex 2 Neighboring gene glutamate rich 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • O-linked glycosylation, organism-specific biosystem (from REACTOME)
    O-linked glycosylation, organism-specific biosystemO-glycosylation is an important post-translational modification (PTM) required for correct functioning of many proteins (Van den Steen et al. 1998, Moremen et al. 2012). The O-glycosylation of protei...
  • O-linked glycosylation of mucins, organism-specific biosystem (from REACTOME)
    O-linked glycosylation of mucins, organism-specific biosystemMucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoa. Mucins' key characteristic is their ability to form gels...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
poly-N-acetyllactosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly-N-acetyllactosamine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
Names
BGnT-8
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7
beta galactosyltransferase BGALT15
beta-1,3-Gn-T8
beta-1,3-N-acetylglucosaminyltransferase 8
beta1,3-N-acetylglucosaminyltransferase 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198540.2NP_940942.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 precursor

    See identical proteins and their annotated locations for NP_940942.1

    Status: VALIDATED

    Source sequence(s)
    AY277592
    Consensus CDS
    CCDS12582.1
    UniProtKB/Swiss-Prot
    Q7Z7M8
    Related
    ENSP00000312700.1, ENST00000321702.2
    Conserved Domains (1) summary
    cl21608
    Location:162349
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41425359..41429024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526934.2XP_011525236.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 isoform X1

    See identical proteins and their annotated locations for XP_011525236.1

    UniProtKB/Swiss-Prot
    Q7Z7M8
    Conserved Domains (1) summary
    cl21608
    Location:162349
    Galactosyl_T; Galactosyltransferase
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