Format

Send to:

Choose Destination

ZNF568 zinc finger protein 568 [ Homo sapiens (human) ]

Gene ID: 374900, updated on 23-Nov-2021

Summary

Official Symbol
ZNF568provided by HGNC
Official Full Name
zinc finger protein 568provided by HGNC
Primary source
HGNC:HGNC:25392
See related
Ensembl:ENSG00000198453 MIM:617566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP568
Expression
Ubiquitous expression in thyroid (RPKM 1.4), ovary (RPKM 1.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF568 in Genome Data Viewer
Location:
19q13.12
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (36916332..36997932)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37407234..37488834)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 790 Neighboring gene zinc finger protein 345 Neighboring gene zinc finger protein 829 Neighboring gene ribosomal protein L31 pseudogene 61 Neighboring gene zinc finger protein 420 Neighboring gene uncharacterized LOC105372390 Neighboring gene Sharpr-MPRA regulatory region 11816 Neighboring gene zinc finger protein 585A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34820, FLJ35804, DKFZp667O0524, DKFZp686B0797

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in embryonic placenta morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204835.3NP_001191764.1  zinc finger protein 568 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC008733, BC016334, BC131547, BX640681
    UniProtKB/Swiss-Prot
    Q3ZCX4
    UniProtKB/TrEMBL
    A2VDJ6, Q96AZ9
    Conserved Domains (5) summary
    smart00349
    Location:48102
    KRAB; krueppel associated box
    COG5048
    Location:247633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:419439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4887
    KRAB; KRAB box
    pfam13465
    Location:487512
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001204836.2NP_001191765.1  zinc finger protein 568 isoform 3

    See identical proteins and their annotated locations for NP_001191765.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008733, AK093123, BX640681
    Consensus CDS
    CCDS56092.1
    UniProtKB/Swiss-Prot
    Q3ZCX4
    UniProtKB/TrEMBL
    Q96AZ9
    Related
    ENSP00000466901.1, ENST00000587857.5
    Conserved Domains (5) summary
    smart00349
    Location:138
    KRAB; krueppel associated box
    COG5048
    Location:184570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:356376
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:323
    KRAB; KRAB box
    pfam13465
    Location:424449
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001204837.2NP_001191766.1  zinc finger protein 568 isoform 3

    See identical proteins and their annotated locations for NP_001191766.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks alternate exons in the 5' coding region and uses a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008733, BC111777, BX640681
    Consensus CDS
    CCDS56092.1
    UniProtKB/Swiss-Prot
    Q3ZCX4
    UniProtKB/TrEMBL
    Q96AZ9
    Related
    ENSP00000394514.1, ENST00000415168.5
    Conserved Domains (5) summary
    smart00349
    Location:138
    KRAB; krueppel associated box
    COG5048
    Location:184570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:356376
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:323
    KRAB; KRAB box
    pfam13465
    Location:424449
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001204838.2NP_001191767.1  zinc finger protein 568 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC008733, AK299626, BC016334, BC108696
    Consensus CDS
    CCDS74351.1
    UniProtKB/Swiss-Prot
    Q3ZCX4
    UniProtKB/TrEMBL
    A0A087WZ84, Q96AZ9
    Related
    ENSP00000389794.1, ENST00000444991.5
    Conserved Domains (5) summary
    smart00349
    Location:137197
    KRAB; krueppel associated box
    COG5048
    Location:278621
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:537557
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4887
    KRAB; KRAB box
    pfam13465
    Location:437462
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001204839.2NP_001191768.1  zinc finger protein 568 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 6) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC008733, AK299626, BC016334
    Consensus CDS
    CCDS56093.1
    UniProtKB/Swiss-Prot
    Q3ZCX4
    UniProtKB/TrEMBL
    Q96AZ9
    Related
    ENSP00000413396.2, ENST00000455427.6
    Conserved Domains (5) summary
    smart00349
    Location:73133
    KRAB; krueppel associated box
    COG5048
    Location:224501
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:473493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:73112
    KRAB; KRAB box
    pfam13465
    Location:373398
    zf-H2C2_2; Zinc-finger double domain
  6. NM_198539.4NP_940941.2  zinc finger protein 568 isoform 1

    See identical proteins and their annotated locations for NP_940941.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC008733, BC031218, BC111777, BX640681
    Consensus CDS
    CCDS42558.1
    UniProtKB/Swiss-Prot
    Q3ZCX4
    UniProtKB/TrEMBL
    Q96AZ9
    Related
    ENSP00000334685.7, ENST00000333987.12
    Conserved Domains (5) summary
    smart00349
    Location:48102
    KRAB; krueppel associated box
    COG5048
    Location:248634
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:420440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4887
    KRAB; KRAB box
    pfam13465
    Location:488513
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    36916332..36997932
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026773.2XP_016882262.1  zinc finger protein 568 isoform X2

    UniProtKB/Swiss-Prot
    Q3ZCX4
    Conserved Domains (5) summary
    smart00349
    Location:138
    KRAB; krueppel associated box
    COG5048
    Location:184570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:356376
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:323
    KRAB; KRAB box
    pfam13465
    Location:424449
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017026779.2XP_016882268.1  zinc finger protein 568 isoform X6

  3. XM_017026775.2XP_016882264.1  zinc finger protein 568 isoform X3

    UniProtKB/Swiss-Prot
    Q3ZCX4
    Conserved Domains (5) summary
    smart00349
    Location:73133
    KRAB; krueppel associated box
    COG5048
    Location:224501
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:473493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:73112
    KRAB; KRAB box
    pfam13465
    Location:373398
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017026774.1XP_016882263.1  zinc finger protein 568 isoform X2

    UniProtKB/Swiss-Prot
    Q3ZCX4
    Conserved Domains (5) summary
    smart00349
    Location:138
    KRAB; krueppel associated box
    COG5048
    Location:184570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:356376
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:323
    KRAB; KRAB box
    pfam13465
    Location:424449
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017026772.1XP_016882261.1  zinc finger protein 568 isoform X1

    UniProtKB/TrEMBL
    A0A087WZ84
    Conserved Domains (5) summary
    smart00349
    Location:137197
    KRAB; krueppel associated box
    COG5048
    Location:278621
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:537557
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4887
    KRAB; KRAB box
    pfam13465
    Location:437462
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017026777.1XP_016882266.1  zinc finger protein 568 isoform X4

  7. XM_017026778.1XP_016882267.1  zinc finger protein 568 isoform X5

  8. XM_017026776.1XP_016882265.1  zinc finger protein 568 isoform X4

Support Center