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Grx1t Glutaredoxin 1, testis-specific [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37483, updated on 6-Jul-2026
Official Symbol
Grx1tprovided by FlyBase
Official Full Name
Glutaredoxin 1, testis-specificprovided by FlyBase
Primary source
FLYBASE:FBgn0034658
Locus tag
Dmel_CG7975
See related
AllianceGenome:FB:FBgn0034658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7975; Dmel\CG7975; Grx-1; Grx1
Summary
Predicted to enable glutathione disulfide oxidoreductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be active in cytoplasm. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Grx1t in Genome Data Viewer
Location:
57F11-57F11; 2-96 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21757345..21757913)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17644850..17645418)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lamin B receptor Neighboring gene long non-coding RNA:CR44750 Neighboring gene long non-coding RNA:CR43983 Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Evidence for a role for the putative Drosophila hGRX1 orthologue in copper homeostasis. Mercer SW, et al. Biometals, 2016 Aug. PMID 27379771
  2. New insights on thioredoxins (Trxs) and glutaredoxins (Grxs) by in silico amino acid sequence, phylogenetic and comparative structural analyses in organisms of three domains of life. Mondal S, et al. Heliyon, 2022 Oct. PMID 36203893, Free PMC Article
  3. Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. Svensson MJ, et al. Hereditas, 2007 Mar. PMID 17567437
  4. Quality of regulatory elements in Drosophila retrogenes. Bai Y, et al. Genomics, 2009 Jan. PMID 18848618, Free PMC Article
  5. Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila. Piacentini L, et al. PLoS Genet, 2009 Oct. PMID 19798443, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione disulfide oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glutathione oxidoreductase (glutathione) activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
glutaredoxin 1, testis-specific
Names
CG7975-PA
Grx-1
Grx1t-PA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21757345..21757913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137765.3 → NP_611609.1  glutaredoxin 1, testis-specific

    See identical proteins and their annotated locations for NP_611609.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KF22, Q9W2D1
    Related
    FBpp0071631
    Conserved Domains (1) summary
    cd03419
    Location:33 → 113
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W2D1 Q9W2D1

Gene LinkOut

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