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LBR Lamin B receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37482, updated on 5-Aug-2022

Summary

Official Symbol
LBRprovided by FlyBase
Official Full Name
Lamin B receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0034657
Locus tag
Dmel_CG17952
See related
AllianceGenome:FB:FBgn0034657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17952; dLBR; Dmel\CG17952
Summary
Enables chromatin binding activity and lamin binding activity. Predicted to be involved in sterol biosynthetic process. Located in nuclear inner membrane. Is integral component of nuclear inner membrane. Is expressed in adult head; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor) and TM7SF2 (transmembrane 7 superfamily member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See LBR in Genome Data Viewer
Location:
57F10-57F11; 2-96 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21720495..21724055)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17608000..17611560)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene High mobility group protein D Neighboring gene uncharacterized protein Neighboring gene Transport and Golgi organization 11 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44750 Neighboring gene Glutaredoxin 1, testis-specific

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the LBR gene: The LBR gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables delta14-sterol reductase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables lamin binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables oxidoreductase activity IKR
Inferred from Key Residues
more info
PubMed 
Process Evidence Code Pubs
involved_in nucleus organization IC
Inferred by Curator
more info
PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lamin B receptor
Names
CG17952-PA
CG17952-PB
CG17952-PC
LBR-PA
LBR-PB
LBR-PC
lamin-B receptor
NP_611608.1
NP_726114.1
NP_726115.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21720495..21724055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137764.3NP_611608.1  lamin B receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611608.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MLV1
    Related
    FBpp0071629, FBtr0071712
    Conserved Domains (1) summary
    cl21511
    Location:279716
    PEMT; Phospholipid methyltransferase
  2. NM_166484.2NP_726114.1  lamin B receptor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726114.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MLV1, Q9W2D2
    Related
    FBpp0071630, FBtr0071713
    Conserved Domains (1) summary
    cl21511
    Location:304741
    PEMT; Phospholipid methyltransferase
  3. NM_166485.2NP_726115.1  lamin B receptor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726115.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MLV1
    Related
    FBpp0071628, FBtr0071711
    Conserved Domains (1) summary
    cl21511
    Location:279716
    PEMT; Phospholipid methyltransferase