Format

Send to:

Choose Destination

KCNC3 potassium voltage-gated channel subfamily C member 3 [ Homo sapiens (human) ]

Gene ID: 3748, updated on 5-Aug-2018

Summary

Official Symbol
KCNC3provided by HGNC
Official Full Name
potassium voltage-gated channel subfamily C member 3provided by HGNC
Primary source
HGNC:HGNC:6235
See related
Ensembl:ENSG00000131398 MIM:176264; Vega:OTTHUMG00000044580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KV3.3; SCA13; KSHIIID
Summary
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014]
Expression
Broad expression in brain (RPKM 4.9), kidney (RPKM 2.9) and 17 other tissues See more
Orthologs

Genomic context

See KCNC3 in Genome Data Viewer
Location:
19q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (50311942..50333515, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50818765..50832634, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene IZUMO family member 2 Neighboring gene myosin heavy chain 14 Neighboring gene Sharpr-MPRA regulatory region 11330/13384 Neighboring gene uncharacterized LOC105372437 Neighboring gene napsin B aspartic peptidase, pseudogene Neighboring gene napsin A aspartic peptidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Voltage gated Potassium channels, organism-specific biosystem (from REACTOME)
    Voltage gated Potassium channels, organism-specific biosystemVoltage-gated K+ channels (Kv) determine the excitability of heart, brain and skeletal muscle cells. Kv form octameric channel with alpha subunits that forms the pore of the channel and associated be...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein tetramerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily C member 3
Names
Shaw-related voltage-gated potassium channel protein 3
potassium channel, voltage gated Shaw related subfamily C, member 3
potassium voltage-gated channel, Shaw-related subfamily, member 3
voltage-gated potassium channel protein KV3.3
voltage-gated potassium channel subunit Kv3.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008134.2 RefSeqGene

    Range
    5001..18870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004977.2NP_004968.2  potassium voltage-gated channel subfamily C member 3

    See identical proteins and their annotated locations for NP_004968.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the protein.
    Source sequence(s)
    AF055989
    Consensus CDS
    CCDS12793.1
    UniProtKB/Swiss-Prot
    Q14003
    Related
    ENSP00000434241.1, OTTHUMP00000232123, ENST00000477616.1, OTTHUMT00000314288
    Conserved Domains (4) summary
    smart00225
    Location:90192
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:343550
    Ion_trans; Ion transport protein
    pfam02214
    Location:90184
    BTB_2; BTB/POZ domain
    pfam07885
    Location:493540
    Ion_trans_2; Ion channel

RNA

  1. NR_110912.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC008655, AK127492
    Related
    ENST00000474951.1, OTTHUMT00000314287

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    50311942..50333515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center