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KCNC2 potassium voltage-gated channel subfamily C member 2 [ Homo sapiens (human) ]

Gene ID: 3747, updated on 12-Feb-2021

Summary

Official Symbol
KCNC2provided by HGNC
Official Full Name
potassium voltage-gated channel subfamily C member 2provided by HGNC
Primary source
HGNC:HGNC:6234
See related
Ensembl:ENSG00000166006 MIM:176256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KV3.2
Summary
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Expression
Restricted expression toward brain (RPKM 14.9) See more
Orthologs
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Genomic context

See KCNC2 in Genome Data Viewer
Location:
12q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (75040078..75209839, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75433858..75603619, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369842 Neighboring gene uncharacterized LOC105369843 Neighboring gene uncharacterized LOC100130268 Neighboring gene CAPS2 antisense RNA 1 Neighboring gene cyclin G2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138196

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ion channel binding IEA
Inferred from Electronic Annotation
more info
 
voltage-gated ion channel activity involved in regulation of presynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
action potential IEA
Inferred from Electronic Annotation
more info
 
cellular response to ammonium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to nitric oxide ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
globus pallidus development IEA
Inferred from Electronic Annotation
more info
 
nitric oxide-cGMP-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
protein heterooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of insulin secretion TAS
Traceable Author Statement
more info
 
regulation of presynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
response to amine IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to light intensity IEA
Inferred from Electronic Annotation
more info
 
response to magnesium ion IEA
Inferred from Electronic Annotation
more info
 
response to nerve growth factor IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
axolemma IEA
Inferred from Electronic Annotation
more info
 
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 
vesicle IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily C member 2
Names
potassium channel, voltage gated Shaw related subfamily C, member 2
potassium voltage-gated channel, Shaw-related subfamily, member 2
shaw-like potassium channel
voltage-gated potassium channel Kv3.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260497.2NP_001247426.1  potassium voltage-gated channel subfamily C member 2 isoform 4

    See identical proteins and their annotated locations for NP_001247426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform KV3.2b.
    Source sequence(s)
    AC073525, AC091534, AF268897, AK309245, DA218546, DC323864
    Consensus CDS
    CCDS58257.1
    UniProtKB/Swiss-Prot
    Q96PR1
    Related
    ENSP00000376966.2, ENST00000393288.2
    Conserved Domains (2) summary
    cd18415
    Location:7166
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:228484
    Ion_trans; Ion transport protein
  2. NM_001260498.2NP_001247427.1  potassium voltage-gated channel subfamily C member 2 isoform KV3.2d

    See identical proteins and their annotated locations for NP_001247427.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (KV3.2d) has a shorter and distinct C-terminus compared to isoform KV3.2b.
    Source sequence(s)
    AC073525, AC091534, AY243473, DA218546, DC323864
    Consensus CDS
    CCDS58256.1
    UniProtKB/Swiss-Prot
    Q96PR1
    UniProtKB/TrEMBL
    A0A024RBF2
    Related
    ENSP00000448301.1, ENST00000550433.5
    Conserved Domains (2) summary
    cd18415
    Location:7166
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:228484
    Ion_trans; Ion transport protein
  3. NM_001260499.2NP_001247428.1  potassium voltage-gated channel subfamily C member 2 isoform 6

    See identical proteins and their annotated locations for NP_001247428.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform KV3.2b.
    Source sequence(s)
    AC073525, AC091534, AK094720, AK294269, DA218546, DC323864
    Consensus CDS
    CCDS58255.1
    UniProtKB/Swiss-Prot
    Q96PR1
    Related
    ENSP00000438423.1, ENST00000540018.5
    Conserved Domains (2) summary
    cd18415
    Location:7166
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:228484
    Ion_trans; Ion transport protein
  4. NM_139136.4NP_631874.1  potassium voltage-gated channel subfamily C member 2 isoform KV3.2a

    See identical proteins and their annotated locations for NP_631874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (KV3.2a) has a shorter and distinct C-terminus compared to isoform KV3.2b.
    Source sequence(s)
    AC091534, AF268897, AK094720, DA218546, DC323864
    Consensus CDS
    CCDS9005.1
    UniProtKB/Swiss-Prot
    Q96PR1
    UniProtKB/TrEMBL
    A0A024RBE3
    Related
    ENSP00000298972.1, ENST00000298972.5
    Conserved Domains (2) summary
    cd18415
    Location:7166
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:228484
    Ion_trans; Ion transport protein
  5. NM_139137.4NP_631875.1  potassium voltage-gated channel subfamily C member 2 isoform KV3.2b

    See identical proteins and their annotated locations for NP_631875.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (KV3.2b).
    Source sequence(s)
    AC073525, AC091534, AY118169, DA218546, DC323864
    Consensus CDS
    CCDS9007.1
    UniProtKB/Swiss-Prot
    Q96PR1
    UniProtKB/TrEMBL
    A0A024RBA5
    Related
    ENSP00000449253.1, ENST00000549446.5
    Conserved Domains (2) summary
    cd18415
    Location:7166
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:228484
    Ion_trans; Ion transport protein
  6. NM_153748.3NP_715624.1  potassium voltage-gated channel subfamily C member 2 isoform KV3.2c

    See identical proteins and their annotated locations for NP_715624.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (KV3.2c) lacks an alternate internal segment and differs in the 3' UTR and coding sequence compared to isoform KV3.2b.
    Source sequence(s)
    AC091534, AK094720, DA218546, DC323864
    Consensus CDS
    CCDS9006.1
    UniProtKB/Swiss-Prot
    Q96PR1
    Related
    ENSP00000319877.2, ENST00000350228.6
    Conserved Domains (2) summary
    cd18415
    Location:7166
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:228484
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    75040078..75209839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719384.4XP_006719447.1  potassium voltage-gated channel subfamily C member 2 isoform X2

    See identical proteins and their annotated locations for XP_006719447.1

    Conserved Domains (2) summary
    cd18415
    Location:7166
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:228484
    Ion_trans; Ion transport protein
  2. XM_006719383.4XP_006719446.1  potassium voltage-gated channel subfamily C member 2 isoform X2

    See identical proteins and their annotated locations for XP_006719446.1

    Related
    ENSP00000497415.1, ENST00000647764.1
    Conserved Domains (2) summary
    cd18415
    Location:7166
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:228484
    Ion_trans; Ion transport protein
  3. XM_006719385.4XP_006719448.1  potassium voltage-gated channel subfamily C member 2 isoform X2

    See identical proteins and their annotated locations for XP_006719448.1

    Conserved Domains (2) summary
    cd18415
    Location:7166
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:228484
    Ion_trans; Ion transport protein
  4. XM_005268855.4XP_005268912.1  potassium voltage-gated channel subfamily C member 2 isoform X3

    See identical proteins and their annotated locations for XP_005268912.1

    Conserved Domains (4) summary
    smart00225
    Location:10159
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:277484
    Ion_trans; Ion transport protein
    pfam02214
    Location:10151
    BTB_2; BTB/POZ domain
    pfam07885
    Location:427474
    Ion_trans_2; Ion channel
  5. XM_006719382.4XP_006719445.1  potassium voltage-gated channel subfamily C member 2 isoform X1

    See identical proteins and their annotated locations for XP_006719445.1

    UniProtKB/Swiss-Prot
    Q96PR1
    UniProtKB/TrEMBL
    A0A024RBE3
    Conserved Domains (2) summary
    cd18415
    Location:7166
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:228484
    Ion_trans; Ion transport protein
  6. XM_017019282.2XP_016874771.1  potassium voltage-gated channel subfamily C member 2 isoform X2

    Conserved Domains (2) summary
    cd18415
    Location:7166
    BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
    pfam00520
    Location:228484
    Ion_trans; Ion transport protein
  7. XM_006719390.4XP_006719453.1  potassium voltage-gated channel subfamily C member 2 isoform X4

    Conserved Domains (2) summary
    smart00225
    Location:10159
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam02214
    Location:10151
    BTB_2; BTB/POZ domain

RNA

  1. XR_001748695.2 RNA Sequence

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