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KRT77 keratin 77 [ Homo sapiens (human) ]

Gene ID: 374454, updated on 13-Mar-2020

Summary

Official Symbol
KRT77provided by HGNC
Official Full Name
keratin 77provided by HGNC
Primary source
HGNC:HGNC:20411
See related
Ensembl:ENSG00000189182 MIM:611158
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K1B; KRT1B
Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Expression
Restricted expression toward skin (RPKM 121.1) See more
Orthologs

Genomic context

See KRT77 in Genome Data Viewer
Location:
12q13.13
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52689612..52703524, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53083396..53097247, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 2 Neighboring gene keratin 1 Neighboring gene keratin 126 pseudogene Neighboring gene DEAD-box helicase 23 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC148087

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cornification TAS
Traceable Author Statement
more info
 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type II cytoskeletal 1b
Names
CK-1B
K77
cytokeratin-1B
keratin 1B
keratin 77, type II
type-II keratin Kb39

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012322.1 RefSeqGene

    Range
    4940..18838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_175078.3NP_778253.2  keratin, type II cytoskeletal 1b

    See identical proteins and their annotated locations for NP_778253.2

    Status: REVIEWED

    Source sequence(s)
    AC055716, BC122558
    Consensus CDS
    CCDS8837.1
    UniProtKB/Swiss-Prot
    Q7Z794
    UniProtKB/TrEMBL
    Q0IIN1
    Related
    ENSP00000342710.3, ENST00000341809.8
    Conserved Domains (3) summary
    pfam00038
    Location:163476
    Filament; Intermediate filament protein
    pfam16208
    Location:56160
    Keratin_2_head; Keratin type II head
    cl23720
    Location:384451
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52689612..52703524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538288.2XP_011536590.1  keratin, type II cytoskeletal 1b isoform X1

    Conserved Domains (1) summary
    pfam00038
    Location:1243
    Filament; Intermediate filament protein
  2. XM_011538289.2XP_011536591.1  keratin, type II cytoskeletal 1b isoform X2

    Conserved Domains (1) summary
    pfam16208
    Location:56160
    Keratin_2_head; Keratin type II head
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