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DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 [ Homo sapiens (human) ]

Gene ID: 374407, updated on 13-Mar-2020

Summary

Official Symbol
DNAJB13provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B13provided by HGNC
Primary source
HGNC:HGNC:30718
See related
Ensembl:ENSG00000187726 MIM:610263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CILD34; TSARG5; TSARG6; RSPH16A
Summary
This gene encodes a member of the heat shock protein 40 co-chaperone family which is produced in large amounts in the testis and is located on the radial spokes of the axoneme in human sperm flagella and other flagellar structures. The encoded protein associates with the sperm annulus, as part of the septin complex, through direct interaction with septin 4, during sperm terminal differentiation. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and male infertility. [provided by RefSeq, Apr 2017]
Expression
Biased expression in testis (RPKM 1.9), lung (RPKM 0.6) and 7 other tissues See more
Orthologs

Genomic context

See DNAJB13 in Genome Data Viewer
Location:
11q13.4
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (73950621..73970287)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73661364..73681713)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly factor 4 homolog Neighboring gene proteasomal ATPase associated factor 1 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 4 Neighboring gene uncoupling protein 2 Neighboring gene developmental pluripotency associated 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • FLJ46748

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axonemal central apparatus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axoneme IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
sperm connecting piece ISS
Inferred from Sequence or Structural Similarity
more info
 
sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily B member 13
Names
DnaJ (Hsp40) homolog, subfamily B, member 13
DnaJ (Hsp40) related, subfamily B, member 13
DnaJ-like protein
radial spoke 16 homolog A
testis and spermatogenesis cell-related protein 6
testis spermatocyte apoptosis-related gene 6 protein
testis spermatogenesis apoptosis-related gene 3 protein
testis spermatogenesis apoptosis-related gene 6 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053111.1 RefSeqGene

    Range
    5708..24963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377263.1NP_001364192.1  dnaJ homolog subfamily B member 13 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP003717
  2. NM_153614.4NP_705842.2  dnaJ homolog subfamily B member 13 isoform 1

    See identical proteins and their annotated locations for NP_705842.2

    Status: REVIEWED

    Source sequence(s)
    AY138810, AY325766
    Consensus CDS
    CCDS8227.1
    UniProtKB/Swiss-Prot
    P59910
    Related
    ENSP00000344431.1, ENST00000339764.5
    Conserved Domains (3) summary
    cd10747
    Location:140302
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:1312
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:465
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    73950621..73970287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545013.2XP_011543315.1  dnaJ homolog subfamily B member 13 isoform X5

    Conserved Domains (2) summary
    pfam00226
    Location:4899
    DnaJ; DnaJ domain
    cl21722
    Location:174238
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
  2. XM_011545014.2XP_011543316.1  dnaJ homolog subfamily B member 13 isoform X6

    Conserved Domains (1) summary
    pfam00226
    Location:4899
    DnaJ; DnaJ domain
  3. XM_017017679.1XP_016873168.1  dnaJ homolog subfamily B member 13 isoform X6

    Conserved Domains (1) summary
    pfam00226
    Location:4899
    DnaJ; DnaJ domain
  4. XM_011545005.2XP_011543307.1  dnaJ homolog subfamily B member 13 isoform X2

    Conserved Domains (3) summary
    smart00271
    Location:4792
    DnaJ; DnaJ molecular chaperone homology domain
    cd10747
    Location:120282
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    TIGR02349
    Location:48292
    DnaJ_bact; chaperone protein DnaJ
  5. XM_011545004.3XP_011543306.1  dnaJ homolog subfamily B member 13 isoform X1

    Conserved Domains (3) summary
    cd10747
    Location:174336
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    TIGR02349
    Location:48346
    DnaJ_bact; chaperone protein DnaJ
    pfam00226
    Location:4899
    DnaJ; DnaJ domain
  6. XM_005273984.3XP_005274041.1  dnaJ homolog subfamily B member 13 isoform X3

    Conserved Domains (3) summary
    cd10747
    Location:86248
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:1258
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:457
    DnaJ; DnaJ domain
  7. XM_024448510.1XP_024304278.1  dnaJ homolog subfamily B member 13 isoform X4

    Conserved Domains (2) summary
    cd10747
    Location:82244
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    cl28246
    Location:2122
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  8. XM_024448508.1XP_024304276.1  dnaJ homolog subfamily B member 13 isoform X4

    Conserved Domains (2) summary
    cd10747
    Location:82244
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    cl28246
    Location:2122
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  9. XM_024448509.1XP_024304277.1  dnaJ homolog subfamily B member 13 isoform X4

    Conserved Domains (2) summary
    cd10747
    Location:82244
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    cl28246
    Location:2122
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  10. XM_011545009.3XP_011543311.1  dnaJ homolog subfamily B member 13 isoform X4

    See identical proteins and their annotated locations for XP_011543311.1

    Conserved Domains (2) summary
    cd10747
    Location:82244
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    cl28246
    Location:2122
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  11. XM_024448507.1XP_024304275.1  dnaJ homolog subfamily B member 13 isoform X4

    Conserved Domains (2) summary
    cd10747
    Location:82244
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    cl28246
    Location:2122
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  12. XM_017017675.1XP_016873164.1  dnaJ homolog subfamily B member 13 isoform X4

    Conserved Domains (2) summary
    cd10747
    Location:82244
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    cl28246
    Location:2122
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  13. XM_011545007.2XP_011543309.1  dnaJ homolog subfamily B member 13 isoform X4

    See identical proteins and their annotated locations for XP_011543309.1

    Conserved Domains (2) summary
    cd10747
    Location:82244
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    cl28246
    Location:2122
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  14. XM_011545015.2XP_011543317.1  dnaJ homolog subfamily B member 13 isoform X7

    Conserved Domains (1) summary
    cd10747
    Location:35161
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

RNA

  1. XR_949909.2 RNA Sequence

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