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NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 [ Homo sapiens (human) ]

Gene ID: 374383, updated on 18-Apr-2021

Summary

Official Symbol
NCR3LG1provided by HGNC
Official Full Name
natural killer cell cytotoxicity receptor 3 ligand 1provided by HGNC
Primary source
HGNC:HGNC:42400
See related
Ensembl:ENSG00000188211 MIM:613714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7H6; B7-H6; DKFZp686O24166
Summary
B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
Expression
Broad expression in colon (RPKM 2.1), duodenum (RPKM 1.9) and 21 other tissues See more
Orthologs
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Genomic context

See NCR3LG1 in Genome Data Viewer
Location:
11p15.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (17351800..17377341)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (17373347..17398888)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 40 Neighboring gene nucleobindin 2 Neighboring gene uncharacterized LOC105376576 Neighboring gene uncharacterized LOC107984316 Neighboring gene potassium inwardly rectifying channel subfamily J member 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NCR3LG1 PubMed
Knockdown of B7 homolog 6 (B7H6; DKFZp686O24166) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686I21167

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
natural cytotoxicity triggering receptor 3 ligand 1
Names
B7 homolog 6
putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202439.3NP_001189368.1  natural cytotoxicity triggering receptor 3 ligand 1 precursor

    See identical proteins and their annotated locations for NP_001189368.1

    Status: VALIDATED

    Source sequence(s)
    AC124798, KC877395
    Consensus CDS
    CCDS55748.1
    UniProtKB/Swiss-Prot
    Q68D85
    Related
    ENSP00000341637.4, ENST00000338965.9
    Conserved Domains (2) summary
    pfam01140
    Location:296377
    Gag_MA; Matrix protein (MA), p15
    cl11960
    Location:105240
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    17351800..17377341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520074.3XP_011518376.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X1

    See identical proteins and their annotated locations for XP_011518376.1

    Conserved Domains (3) summary
    smart00410
    Location:5110
    IG_like; Immunoglobulin like
    pfam01140
    Location:267348
    Gag_MA; Matrix protein (MA), p15
    cl11960
    Location:76211
    Ig; Immunoglobulin domain
  2. XM_011520072.3XP_011518374.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X1

    See identical proteins and their annotated locations for XP_011518374.1

    Conserved Domains (3) summary
    smart00410
    Location:5110
    IG_like; Immunoglobulin like
    pfam01140
    Location:267348
    Gag_MA; Matrix protein (MA), p15
    cl11960
    Location:76211
    Ig; Immunoglobulin domain
  3. XM_011520073.3XP_011518375.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X1

    See identical proteins and their annotated locations for XP_011518375.1

    Conserved Domains (3) summary
    smart00410
    Location:5110
    IG_like; Immunoglobulin like
    pfam01140
    Location:267348
    Gag_MA; Matrix protein (MA), p15
    cl11960
    Location:76211
    Ig; Immunoglobulin domain
  4. XM_011520075.3XP_011518377.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X1

    See identical proteins and their annotated locations for XP_011518377.1

    Conserved Domains (3) summary
    smart00410
    Location:5110
    IG_like; Immunoglobulin like
    pfam01140
    Location:267348
    Gag_MA; Matrix protein (MA), p15
    cl11960
    Location:76211
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009913.1: Suppressed sequence

    Description
    NM_001009913.1: This RefSeq was permanently suppressed because it is mostly repetitive sequence.
  2. NR_026750.1: Suppressed sequence

    Description
    NR_026750.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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