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NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 [ Homo sapiens (human) ]

Gene ID: 374383, updated on 5-Mar-2024

Summary

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Official Symbol
NCR3LG1provided by HGNC
Official Full Name
natural killer cell cytotoxicity receptor 3 ligand 1provided by HGNC
Primary source
HGNC:HGNC:42400
See related
Ensembl:ENSG00000188211 MIM:613714; AllianceGenome:HGNC:42400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7H6; B7-H6; DKFZp686O24166
Summary
B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
Expression
Broad expression in colon (RPKM 2.1), duodenum (RPKM 1.9) and 21 other tissues See more
Orthologs
all
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Genomic context

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See NCR3LG1 in Genome Data Viewer
Location:
11p15.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (17351800..17381661)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (17449460..17474942)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (17373347..17398888)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3183 Neighboring gene nucleobindin 2 Neighboring gene uncharacterized LOC124902640 Neighboring gene uncharacterized LOC105376576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:17373285-17373886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:17373887-17374488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4488 Neighboring gene MPRA-validated peak1220 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr11:17397887-17398425 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:17399732-17400931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17408081-17408734 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:17408735-17409388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3186 Neighboring gene Sharpr-MPRA regulatory region 5134 Neighboring gene potassium inwardly rectifying channel subfamily J member 11 Neighboring gene VISTA enhancer hs1977 Neighboring gene ATP binding cassette subfamily C member 8 Neighboring gene succinate dehydrogenase complex subunit C pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. B7H6 silencing increases chemosensitivity to dacarbazine and suppresses cell survival and migration in cutaneous melanoma. Mohammadi A, et al. Melanoma Res, 2023 Jun 1. PMID 37053079
  2. B7-H6 as a Diagnostic Biomarker for Cervical Squamous Cell Carcinoma. Liu X, et al. Genet Test Mol Biomarkers, 2021 Jul. PMID 34280008
  3. NCR3LG1 (B7-H6) is a potential prognostic factor for bladder cancer patients. Zhao L, et al. Biomarkers, 2021 May. PMID 33523715
  4. Dual role of B7-H6 as a novel prognostic marker in hepatocellular carcinoma. Qiu H, et al. APMIS, 2021 Mar. PMID 33220098
  5. Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis. Chen H, et al. J Immunol Res, 2020. PMID 32322592, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. B7H6 silencing increases chemosensitivity to dacarbazine and suppresses cell survival and migration in cutaneous melanoma.
    Title: B7H6 silencing increases chemosensitivity to dacarbazine and suppresses cell survival and migration in cutaneous melanoma.
  2. B7-H6 enhances F-actin rearrangement by targeting c-MYC activation to promote medulloblastoma migration and invasion.
    Title: B7-H6 enhances F-actin rearrangement by targeting c-MYC activation to promote medulloblastoma migration and invasion.
  3. NCR3LG1 (B7-H6) is a potential prognostic factor for bladder cancer patients.
    Title: NCR3LG1 (B7-H6) is a potential prognostic factor for bladder cancer patients.
  4. Immune checkpoint molecules B7-H6 and PD-L1 co-pattern the tumor inflammatory microenvironment in human breast cancer.
    Title: Immune checkpoint molecules B7-H6 and PD-L1 co-pattern the tumor inflammatory microenvironment in human breast cancer.
  5. B7-H6 as a Diagnostic Biomarker for Cervical Squamous Cell Carcinoma.
    Title: B7-H6 as a Diagnostic Biomarker for Cervical Squamous Cell Carcinoma.
  6. Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy.
    Title: Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy.
  7. Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in Contrast to BAG6 Only Marginally Released via Extracellular Vesicles.
    Title: Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in Contrast to BAG6 Only Marginally Released via Extracellular Vesicles.
  8. Dual role of B7-H6 as a novel prognostic marker in hepatocellular carcinoma.
    Title: Dual role of B7-H6 as a novel prognostic marker in hepatocellular carcinoma.
  9. Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis.
    Title: Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis.
  10. The prognostic value of B7-H6 in esophageal squamous cell carcinoma.
    Title: The prognostic value of B7-H6 in esophageal squamous cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NCR3LG1 PubMed
Knockdown of B7 homolog 6 (B7H6; DKFZp686O24166) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686I21167

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
natural cytotoxicity triggering receptor 3 ligand 1
Names
B7 homolog 6
putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202439.3 → NP_001189368.1  natural cytotoxicity triggering receptor 3 ligand 1 precursor

    See identical proteins and their annotated locations for NP_001189368.1

    Status: VALIDATED

    Source sequence(s)
    AC124798, KC877395
    Consensus CDS
    CCDS55748.1
    UniProtKB/Swiss-Prot
    Q68D85, Q7Z3M6
    Related
    ENSP00000341637.4, ENST00000338965.9
    Conserved Domains (2) summary
    pfam01140
    Location:296 → 377
    Gag_MA; Matrix protein (MA), p15
    cl11960
    Location:105 → 240
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    17351800..17381661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426906.1 → XP_047282862.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X1

    UniProtKB/Swiss-Prot
    Q68D85, Q7Z3M6

  2. XM_011520074.4 → XP_011518376.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X2

    See identical proteins and their annotated locations for XP_011518376.1

    Conserved Domains (3) summary
    smart00410
    Location:5 → 110
    IG_like; Immunoglobulin like
    pfam01140
    Location:267 → 348
    Gag_MA; Matrix protein (MA), p15
    cl11960
    Location:76 → 211
    Ig; Immunoglobulin domain

  3. XM_011520075.4 → XP_011518377.1  natural cytotoxicity triggering receptor 3 ligand 1 isoform X2

    See identical proteins and their annotated locations for XP_011518377.1

    Conserved Domains (3) summary
    smart00410
    Location:5 → 110
    IG_like; Immunoglobulin like
    pfam01140
    Location:267 → 348
    Gag_MA; Matrix protein (MA), p15
    cl11960
    Location:76 → 211
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    17449460..17474942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009913.1: Suppressed sequence

    Description
    NM_001009913.1: This RefSeq was permanently suppressed because it is mostly repetitive sequence.

  2. NR_026750.1: Suppressed sequence

    Description
    NR_026750.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68D85.1 GenPept UniProtKB/Swiss-Prot:Q68D85

Gene LinkOut

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